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  • Bilingual Instruction Strategy (BIS) Vocabulary Curriculum for Fourth Grade English Learners
    The data for this project consists of curriculum materials developed for a vocabulary intervention. Two parallel sets of instructional products were created: one monolingual (English-only) and one bilingual (English-Spanish). Each curriculum set contains materials designed for structured delivery of explicit vocabulary instruction over six weeks. Types of materials include: * Teacher lesson cards: Step-by-step guidance for instruction, including pre-teaching of vocabulary, purpose-setting for reading, read-aloud prompts, comprehension checks, and closing activities. * Student reading passages: Thematic texts that embed target vocabulary words in context. * Vocabulary cards: Word-by-word instructional supports including (a) the focal word, (b) child-friendly definitions, (c) contextual examples, (d) visual supports (images), and (e) oral repetition prompts. * Vocabulary review cards: Summative review prompts with definitions, images, and opportunities for repetition and extension questions.
  • MD-NOS1 KO
    Background: Acute kidney injury (AKI) causes rapid loss of renal function and leads to high morbidity and mortality. Our previous research has shown that neuronal nitric oxide synthase (NOS1) influences nitric oxide (NO)-mediated dilation of the afferent arteriole, thereby inhibiting tubuloglomerular feedback (TGF), which plays a critical role in glomerular filtration rate (GFR). Methods: We generated inducible macula densa–specific NOS1 knockout mice (NKCC2-Cre- NOS1 flox/flox) and introduced AKI by 18 min bilateral renal ischemia at 37 °C, followed by 48 h reperfusion. The kidney injury was assessed by measuring GFR, plasma creatinine, histology, cytokines, apoptosis, fibrotic factors, and proteomics. Results: Deletion of NOS1 was confirmed through immunofluorescence double staining of NKCC2 and NOS1. The results showed that crossing NKCC2 cre line with NOS1 flox line induces a complete deletion of NOS1 from the macula densa cells. In response to IR-AKI, compared with wild-type controls, NOS1 knockouts showed a dramatic GFR decline (236 ± 66 to 24 ± 22 µL/min) and elevated creatinine, alongside more severe tubular damages evidenced by H&E staining. Cytokine array analysis showed chemokines such as MCP-1, CXCL1 and macrophage marker CD68 were significantly increased; Western blot analysis showed cleaved caspase-3 levels were significantly increased, indicating enhanced apoptosis. Additionally, fibrosis markers TIMP1, collagen-3, and α-SMA were significantly upregulated at both mRNA and protein levels. We further observed increased hypoxia marker HIF-1α in MD-NOS1 KO mice. Global label-free proteomic profiling with targeted validation identified genotype-dependent responses involving haptoglobin, Tacstd2, and Cyp20a1, linking NOS1 deficiency to exaggerated inflammatory, fibrotic, and metabolic pathways. Conclusions: These findings highlight a novel role of NOS1 in AKI pathophysiology and suggest targeting NOS1 could be a therapeutic strategy to mitigate AKI severity, identified Hp as a downstream plasma signal of NOS1-dependent AKI responses, suggesting potential translational value pending human validation. 
  • Long-chain Acyl-CoA Synthetase 3 (ACSL3) in Vascular Dementia
    The raw data of research article "ACSL3 is a promising therapeutic target for alleviating anxiety and depression in Alzheimer's disease"
  • NSF 3D Wetlands Maps
    The NSF 3D Wetlands project produced 2-meter spatial resolution maps of elevation and habitat cover for all states bordering the Gulf of (Mexico||America). A Digital Elevation Model (DEM) was generated from a compilation of LiDAR datasets. Habitat cover was generated using a machine learning model run on MAXA Worldview 2 and 3 multiband imagery.
  • Ampicillin- and Multidrug-Resistant Escherichia coli and Enterococcus spp. in Costa Rican Wastewater and Surface Water
    This dataset contains the data that corresponds to the information included in 'Ampicillin- and Multidrug-Resistant Escherichia coli and Enterococcus spp. in Costa Rican Wastewater and Surface Water' (in review). The data include measurements of concentrations of total and ampicillin-resistant fecal indicator bacteria (E. coli and enterococci) from four sites in and near a wastewater treatment plant in Puntarenas, Costa Rica. The four sites at which samples were collected were the influent from hospital wastewater, influent from residential wastewater, treated wastewater effluent, and the estuary in which treated effluent is discharged. Frequency of ampicillin resistance is recorded, and ampicillin-resistant isolates were confirmed to species or genus before further testing. Multidrug resistance testing was conducted via the Kirby Bauer assay, and the zones of inhibition for each isolate, as well as the interpretation (resistant, intermediate, and sensitive), are provided. Samples were collected from each site during four sampling events from October to November 2019.
  • Water saturation in texturally porous carbonate rocks: Shock thermodynamics and dampening of the shock.
    iSALE configuration files, collected data, and plotting means for the mesoscale models
  • Baseline Expression Levels of WNT8B, KRT2, and TTLL13P are associated with abrocitinib response in atopic dermatitis
    Our real-world data from 96 patients confirms that abrocitinib induces rapid clinical improvement and broadly downregulates genes in cytokine and JAK-STAT signaling pathways. We also identified that patients achieving EASI-90 response had a distinct baseline profile characterized by lower Th2 cytokines and a specific transcriptomic signature of high WNT8B and low TTLL13p and KRT2 expression. This signature was validated as a predictive biomarker in an independent cohort, suggesting it can be used to stratify patients for a higher likelihood of achieving minimal disease activity with abrocitinib.
  • Sequencing-free whole-genome spatial transcriptomics at single-molecule resolution
    Recent breakthroughs in spatial transcriptomics technologies have enhanced our understanding of diverse cellular identities, spatial organizations, and functions. Yet existing spatial transcriptomics tools are still limited in either transcriptomic coverage or spatial resolution, hindering unbiased, hypothesis-free transcriptomic analyses at high spatial resolution. Here we develop Reverse-padlock Amplicon Encoding FISH (RAEFISH), an image-based spatial transcriptomics method with whole-genome coverage and single-molecule resolution in intact tissues. We demonstrate spatial profiling of 23,000 human or 22,000 mouse transcripts in single cells and tissue sections. Our analyses reveal transcript-specific subcellular localization, cell-type-specific and cell-type-invariant zonation-dependent transcriptomes, and gene programs underlying preferential cell-cell interactions. Finally, we further develop our technology for direct spatial readout of gRNAs in an image-based high-content CRISPR screen. Overall, these developments provide the research community with a broadly applicable technology that enables high-coverage, high-resolution spatial profiling of both long and short, native and engineered RNA species in many biomedical contexts.
  • CAFVRPILA-instances
    In this repository, there are the benchmark instances to test the CAFVRPILA problem.
  • DVRP-FPTW-instances
    In this repository, there are benchmark instances to test the DVRPFPTW.
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