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Background: Bovine babesiosis, primarily caused by the protozoan parasites of the Babesia genus, is a tick-borne disease of major veterinary and economic importance. Its prevalence is influenced by climatic factors, particularly temperature and humidity, which affect tick vector dynamics. Objective: This study investigates global trends in bovine babesiosis from 2005 to 2024 and explores associations with climate variables, including land surface air temperature and atmospheric methane concentrations. Methods: Data were obtained from the World Organisation for Animal Health (WOAH) and climate datasets from the Meteorological (MET) Office, International Monetary Fund (IMF), and National Aeronautics and Space Administration (NASA). Descriptive and correlation analyses were conducted using Python to assess disease trends and their relationship with environmental factors. Results: A global decline in bovine babesiosis cases was observed, from 58,700 in 2006 to 25,500 in 2024. Africa and Asia reported the highest burdens, with Egypt, India, and Sri Lanka leading. Strong negative correlations were found between methane concentrations and disease metrics (cases, outbreaks, deaths), and weaker but significant negative correlations with temperature anomalies. Tropical regions exhibited higher case numbers, while temperate regions showed greater sensitivity to climate fluctuations. Conclusion: The findings suggest complex interactions between climate change and bovine babesiosis epidemiology. A One Health approach is essential to address the interconnected challenges of animal health, environmental change, and zoonotic risks. Proactive, climate-informed interventions are needed to mitigate the disease’s impact on livestock productivity and global food security.

This dataset supports the manuscript: DNMT3A-R882 mutation intrinsically mimics maladaptive myelopoiesis from human haematopoietic stem cells Giovanna Mantica1*, Aditi Vedi1,2*, Amos Tuval3§, Hector Huerga-Encabo4§, Daniel Hayler1§, Aleksandra Krzywon1,5, Emily Mitchell6, William Dunn1, Tamir Biezuner3, Kendig Sham1, Antonella Santoro1, Joe Lee6, Adi Danin3, Noa Chapal3, Yoni Moskovitz3,7, Andrea Arruda8, Edoardo Fiorillo9, Valeria Orru9, Michele Marongiu9, Eoin McKinney10, Francesco Cucca9,11, Matthew Collin12, Mark Minden8, Peter Campbell6, George S Vassiliou1, Margarete Fabre1, Jyoti Nangalia1,6, Dominique Bonnet4, Liran Shlush3,7,8, Elisa Laurenti1 * These authors contributed equally. § These authors contributed equally. Affiliations: 1 Department of Haematology and Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK. 2 Department of Paediatric Oncology, Cambridge University Hospitals NHS Foundation Trust 3 Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel. 4 Haematopoietic Stem Cell Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK 5 Department of Biostatistics and Bioinformatics, Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice Branch, Gliwice, Poland 6 Wellcome Sanger Institute, Hinxton, CB10 1SA, UK 7 Division of Haematology Rambam Healthcare Campus, Haifa 31096, Israel. 8 Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 2M9, Canada. 9 Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Lanusei, Italy. 10 Cambridge Institute of Therapeutic Immunology & Infectious Disease, University of Cambridge, Cambridge, UK 11 Dipartimento di Scienze Biomediche, Università degli Studi di Sassari, Sassari, Italy 12 Translational and Clinical Research Institute, Newcastle University, Newcastle-upon-Tyne, UK

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This study examined the relationships between parental verbal aggression, parental responsiveness, and young adults' relational satisfaction with their parents in the Ghanaian cultural context. Drawing from a sample of 366 young adults (freshmen undergraduates) selected through cluster sampling at the University of Cape Coast, this research assessed the correlation between parental communication styles on relational outcomes

Colorectal cancer (CRC) remains the second-leading cause of cancer-associated deaths, indicating an urgent need for improved therapeutic options. We previously generated antibody-drug conjugates (ADCs) targeting the cancer stem-like cell marker leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5). However, tumor relapse due to LGR5 downregulation and suboptimal payload selection warranted strategies to improve ADC efficacy. Here we report cetuximab, an EGFR-targeting monoclonal antibody indicated for RASWT metastatic CRC, augments LGR5 expression independent of RAS/PIK3CA mutation status and promotes EGFR-LGR5 interactions. Furthermore, we describe the development of LGR5 ADCs incorporating a camptothecin-derived payload that is well-tolerated and significantly inhibits tumor growth. Importantly, cetuximab in combination with LGR5 ADCs results in enhanced tumor inhibition or regression versus single-agent treatment and extends survival in RASMUT patient-derived xenografts. These findings support growing evidence that ADC combination therapies may be more effective than monotherapies and suggests a broader clinical use for cetuximab in treating RASMUT CRC.

Supplemental figures for the manuscript “Safe and Effective Acne Treatment Across Skin Types With a 1726-nm Sebum-Selective Laser: One-Year Data From a Prospective Multicenter Study”. Authors: David Goldberg, MD, JD, Steve Ronan, MD, Ashish C. Bhatia, MD, FAAD, Sunil S. Dhawan, MD, Jeremy B. Green, MD, Suzanne L Kilmer, MS, MD, FAAD, William Kwan, MD, Linda Stein Gold, MD, Jonathan S. Weiss, MD, Margot Doucette, Michael Karavitis, Ph.D., Jeffrey S. Dover, MD, FRCPC Journal: JAAD This dataset contains the supplemental images referenced in the article. Please cite the manuscript when using these files.

We investigated the effect of the intestinal microenvironment on human APS. Microbiota composition was analyzed by shotgun sequencing. We measured fecal short chain fatty acids and fecal calprotectin levels.

The research hypothesis guiding this work is based on the premise that the territorial and urban diagnosis of the Southern, Northern, and Eastern regions of the Dominican Republic makes it possible to identify imbalances in urban planning and to understand the differentiated dynamics between primary and secondary cities. This analysis facilitates the interpretation of growth patterns, infrastructure distribution, and opportunities for sustainable regional development. The collected data show that each region presents particularities in its territorial structure: in the South, a marked population dispersion and deficiencies in basic infrastructure; in the North, concentration in urban hubs with greater economic dynamism; and in the East, growth linked to tourism that impacts territorial configuration. Likewise, the contrast between primary and secondary cities reveals inequalities in access to services, urban planning, and integration with their regional context. The most relevant findings highlight the need to strengthen regional and urban planning through management instruments that integrate environmental, economic, and social factors. These results can be interpreted as evidence of the urgency of a balanced approach to territorial development that not only enhances primary cities but also consolidates the strategic role of secondary cities within the national urban network. The information was collected through regional surveys, direct observation, cartographic analysis, document review, and field studies conducted as part of the course Urban Design II (ARQ-804). The data can be used as inputs for future research in urbanism and territorial planning, as well as for the formulation of regional planning proposals that address the current challenges of urban development in the country.

This folder contains code and data needed to replicate "Green Tilts," by Lubos Pastor, Robert F. Stambaugh, and Lucian A. Taylor.

Venture capitals, corporate key core technological innovation and ESG performance