Low and heterogeneous prevalence of glucose-6-phosphate dehydrogenase deficiency in different settings in Ethiopia using phenotyping and genotyping approaches
Contributors: Shitaye, Getasew, Gadisa, Endalamaw, Grignard, Lynn, Shumie, Girma, Chali, Wakweya, Menberu, Temesgen, Belachew, Mulualem, Tegegn, Getaneh, Challi, Sagni, Curry, Jonathan
... 8-Aminoquinolines such as primaquine clear mature Plasmodium falciparum gametocytes that are responsible for transmission from human to mosquitoes and bring radical cure in Plasmodium vivax by clearing dormant liver stages. Deployment of primaquine is thus of relevance for malaria elimination efforts but challenged by the widespread prevalence of glucose-6-phosphate dehydrogenase deficiency (G6PDd) in endemic countries since primaquine in G6PDd individuals may lead to acute haemolysis. In this study, the prevalence of G6PDd was investigated in different settings in Ethiopia using phenotyping and genotyping approaches. Collection consists of three files: File 1 is a flow chart for genotyping and data analysis. Indicated in a) is the schematic presentation of the quality check for data analysis and in b) is the genotyping procedure; File 2 contains KASP Primer sequences; and file 3 contains a Genotyping overview.
Contributors: Foster, Nicola, Hanifa, Yasmeen, Pillai, Natasha, Roycent, Tumbare, Fielding, Katherine, Vassall, Anna, Grant, Alison D., Grant, Alison D., Churchyard, Gavin J., Chihota, Violet
... The costs incurred by patients in seeking care are considered a potential barrier to healthcare seeking behaviour. Given the global move towards Universal Health Care (UHC) which includes financial protection from the cost of ill health, there is a need to estimate the burden of costs incurred by patients to identify possible policy interventions. We used patient cost data collected alongside the “Xpert for people attending HIV/AIDS care: test or review?” (XPHACTOR) study to estimate the costs incurred by the study population when accessing care. In addition, we also looked at the cost burden on caregivers. This dataset includes observations for 289 people accessing HIV/AIDS care among
Dataset for "Confirmation of cholera by rapid diagnostic test amongst patients admitted to the cholera treatment centre in Uvira, Democratic Republic of the Congo"
Contributors: Jeandron, Aurelie, Cumming, Oliver, Rumedeka, Baron Bashige, Saidi, Jaime Mufitini, Cousens, Simon
... Anonymised dataset containing details on patients admitted to the Uvira Cholera Treatment Centre (CTC) who were tested for cholera with rapid diagnostic tests (RDTs) between April 2016 and November 2017. Variables include: ID, Admission week, Weekly rain, Sex, Age group, Stay duration, Outcome, Residence area, ResidenceAS, and Confirmation
Contributors: Vanobberghen, Fiona, Weiss, Helen, D’Souza, Ethel, Patel, Vikram, Rahman, Atif, Fuhr, Daniela, Weobung, Benedict, Lazarus, Anisha
... An anonymised dataset of 280 women (one row per woman) who gave informed consent to participate in an individually-randomised, parallel, superiority, controlled trial in Goa, India in 2014-2016. The intervention was an adapted version of the Thinking Healthy Programme, delivered by peers; the control was enhanced usual care. Further details are available in the published protocol and paper. The dataset contains records of variables on stratified randomisation, socio-demographic information, depression and related outcomes, and therapy adherence. Visits occurred at baseline, and 3 and 6 months post-natal.
Contributors: Vanobberghen, Fiona, Weiss, Helen, Zaidi, Ahmed, Patel, Vikram, Rahman, Atif, Sikander, Siham, Fuhr, Daniela, Ahmad, Ikhlaq
... An anonymised dataset of 570 women (one row per woman) who gave informed consent to participate in a cluster randomised, parallel, superiority, controlled trial in Rawalpindi, Pakistan in 2014-2017. The intervention was an adapted version of the Thinking Healthy Programme, delivered by peers; the control was enhanced usual care. Further details are available in the published protocol and paper. The dataset contains records of variables on stratified randomisation and clusters, socio-demographic information, depression and related outcomes, and therapy adherence. Visits occurred at baseline, and 3 and 6 months post-natal.
Data for: Identifying human encounters that shape the transmission of Streptococcus pneumoniae and other acute respiratory infections
Contributors: le Polain de Waroux, Olivier, Flasche, Stefan, Kucharski, Adam J, Langendorf, Celine, Ndazima, Donny, Mwanga-Amumpaire, Juliet, Grais, Rebecca F, Cohuet, Sandra, Edmunds, W John
... This dataset contained the data that was used in the analysis of the manuscript entitled "Identifying human encounters that shape the transmission of Streptococcus pneumoniae and other acute respiratory infections". The study was conducted in Sheema North Sub-District (South-West Uganda) between January and March 2014. Sixty clusters were randomly selected from the 215 villages and two small district towns (Kabwohe and Itendero) in the study area, proportionally to the population size of each village and town. In each cluster, from 29 or 30 individuals randomly sampled from different households for inclusion in a nasopharyngeal carriage study, a subset of 11 or 12 individuals were selected to answer questions about their social contacts and their history of respiratory illness in the last two weeks, in addition to having a nasopharyngeal swab taken. For the social contact questionnaire, participants were first asked to list all the individuals with whom they had a two-way conversational contact lasting for ≥5 minutes during a period of approximately 24 hours prior to the survey day (from wake up the previous day until wake up on the survey day). Such encounters were defined as ‘ordinary contacts’. For each reported ordinary contact, participants (or their parent/guardian) were asked to estimate the contact’s age (or estimated age), how long the encounter lasted for and whether it involved skin-to-skin touch or utensils passed from mouth to mouth (either of those defining ‘physical contacts’). For very short social encounters (<5 minutes), which were defined as ‘casual contacts’ (e.g. seeing someone on the way, encounter in a shop etc.), participants were asked to estimate the number of encounters based on pre-defined categories (<10 contacts, 10-19 contacts, 20-29 contacts, ≥30 contacts), but not to provide further details about each contact. Next, participants were asked about respiratory symptoms experienced in the two weeks prior to the survey, including any of the following: cough, runny nose, sneezing, sore throat, difficulty breathing. Finally, after the interview was completed, a nasopharyngeal swab was taken from each participant. The data dictionary for this dataset can be found in the corresponding manuscript files
Additional file 2: of Medications that reduce emergency hospital admissions: an overview of systematic reviews and prioritisation of treatments
Contributors: Bobrovitz, Niklas, Heneghan, Carl, Onakpoya, Igho, Fletcher, Benjamin, Collins, Dylan, Tompson, Alice, Lee, Joseph, Nunan, David, Fisher, Rebecca, Scott, Brittney
... Rates of emergency hospitalisations are increasing in many countries, leading to disruption in the quality of care and increases in cost. Therefore, identifying strategies to reduce emergency admission rates is a key priority. There have been large-scale evidence reviews to address this issue; however, there have been no reviews of medication therapies, which have the potential to reduce the use of emergency health-care services. The objectives of this study were to review systematically the evidence to identify medications that affect emergency hospital admissions and prioritise therapies for quality measurement and improvement. This was a systematic review of systematic reviews. We searched MEDLINE, PubMed, the Cochrane Database of Systematic Reviews & Database of Abstracts of Reviews of Effects, Google Scholar and the websites of ten major funding agencies and health charities, using broad search criteria. We included systematic reviews of randomised controlled trials that examined the effect of any medication on emergency hospital admissions among adults. We assessed the quality of reviews using AMSTAR. To prioritise therapies, we assessed the quality of trial evidence underpinning meta-analysed effect estimates and cross-referenced the evidence with clinical guidelines. We identified 140 systematic reviews, which included 1968 unique randomised controlled trials and 925,364 patients. Reviews contained 100 medications tested in 47 populations. We identified high-to moderate-quality evidence for 28 medications that reduced admissions. Of these medications, 11 were supported by clinical guidelines in the United States, the United Kingdom and Europe. These 11 therapies were for patients with heart failure (angiotensin-converting-enzyme inhibitors, angiotensin II receptor blockers, aldosterone receptor antagonists and digoxin), stable coronary artery disease (intensive statin therapy), asthma exacerbations (early inhaled corticosteroids in the emergency department and anticholinergics), chronic obstructive pulmonary disease (long-acting muscarinic antagonists and long-acting beta-2 adrenoceptor agonists) and schizophrenia (second-generation antipsychotics and depot/maintenance antipsychotics). We identified 11 medications supported by strong evidence and clinical guidelines that could be considered in quality monitoring and improvement strategies to help reduce emergency hospital admission rates. The findings are relevant to health systems with a large burden of chronic disease and those managing increasing pressures on acute health-care services.
Contributors: Shakur-Still, Haleema, Roberts, Ian, Fawole, Bukola, Kuti, Modupe, Olayemi, Oladapo O., Bello, Adenike, Huque, Sumaya, Ogunbode, Olayinka, Kotila, Taiwo, Aimakhu, Chris O.
... The WOMAN trial is an international clinical trial to study the effect of tranexamic acid on death, hysterectomy and other maternal outcomes, in women with PPH.14. The trial tested whether tranexamic acid, a blood clot stabiliser discovered in Japan in the 1950’s, could become an essential tool for fighting excessive bleeding soon after giving birth. This condition, known as postpartum haemorrhage, is the number one cause of maternal death around the world, particularly in low and middle income countries. Dataset contains baseline and follow-up measurements for: D-dimer concentration (mg/L), Maximum lysis (%), Haemoglobin concentration (g/L), International normalized ratio (INR), Prothrombin time (seconds), Activated partial thromboplastin time (seconds), Fibrinogen concentration (g/L), Clotting time (seconds), Amplitude (firmness) at 5 minutes (mm), Amplitude at 10 minutes (mm), Clot lysis at 30 and 60 minutes (%), and Maximum clot firmness (mm). THE DATASET CAN BE DOWNLOADED FROM THE FREEBIRD PLATFORM AT https://ctu-app.lshtm.ac.uk/freebird/.
Reported contacts dataset for "Structure and consistency of self-reported social contact networks in British secondary schools"
Contributors: Kucharski, Adam J., Wenham, Clare, Brownlee, Polly, Racon, Lucie, Widmer, Natasha, Eames, Ken T. D., Conlan, Andrew J. K.
... Self-reported social mixing patterns are commonly used in mathematical models of infectious diseases. It is particularly important to quantify patterns for school-age children given their disproportionate role in transmission, but it remains unclear how the structure of such social interactions changes over time. By integrating data collection into a public engagement programme, we examined self-reported contact networks in year 7 groups in four UK secondary schools. We collected data from 460 unique participants across four rounds of data collection conducted between January and June 2015, with 7,315 identifiable contacts reported in total. Although individual-level contacts varied over the study period, we were able to obtain out-of-sample accuracies of more than 90% and F-scores of 0.49–0.84 when predicting the presence or absence of social contacts between specific individuals across rounds of data collection. Network properties such as clustering and number of communities were broadly consistent within schools between survey rounds, but varied significantly between schools. Networks were assortative according to gender, and to a lesser extent school class, with the estimated clustering coefficient larger among males in all surveyed co-educational schools. Our results demonstrate that it is feasible to collect longitudinal self-reported social contact data from school children and that key properties of these data are consistent between rounds of data collection.
Contributors: Kuteesa, Monica O., Weiss, Helen A., Abaasa, Andrew, Nash, Stephen, Nsubuga, Rebecca N., Newton, Rob, Seeley, Janet, Kamali, Anatoli, Kuteesa, Monica, Nash, Stephen
... Dataset and supporting documentation collected as part of the HIV combination prevention study, a cluster randomised trial investigating the feasibility of conducting HIV combination prevention interventions in fishing communities in Uganda. The dataset contains variables collected from participants including social demographics, risk behaviour, the uptake of selected HIV prevention methods, and HIV testing.