Contributors: Esteban Finol
... raw DENV genomic data for Finol E. & Ooi EE. Iscience submision
Contributors: UnaElsLive Natra, mdgmatest5 live
... RDM - File Type Support 21May2019 ElsCustomer Apart from .u3d all files preview [ .obj / .ply / .vtk / .stl / .ent / .brk / .pdb / .pse / .mol / .mol2 / .cif / .u3d / .dcm / .nii] - .pse is not supported
Data for: Structural modifications of 2,3-indolobetulinic acid: design and synthesis of highly potent α-glucosidase inhibitors
Contributors: Elmira Khusnutdinova, Thi Tu Anh Le, Tra Nguyen Thanh, Anastasiya V. Petrova, Denis Babkov, Oxana Kazakova, Ha Nguyen Thi Thu, Cham Ba Thi
... A series of nineteen nitrogen-containing lupane triterpenoids was obtained by modification of C2, C3, C20 and C28 positions of betulonic acid and their α-glucosidase inhibiting activity was investigated. Being a leader compound from our previous study, 2,3-indolo-betulinic acid was used as the main template for different modifications at C-(28)-carboxyl group to obtain cyano-, methylcyanoethoxy-, propargyloxy- and carboxamide derivatives. 20-Oxo- and 29-hydroxy-20-oxo-30-nor-analogues of 2,3-indolo-betulinic acid were synthesized by ozonolysis of betulonic acid followed by Fischer indolization reaction. To compare the influence of the fused indole or the seven membered A-ring on the inhibitory activity, lupane A-azepanones with different substituents at C28 were synthesized. The structure-activity relationships revealed that the enzyme inhibition activity dramatically increased (up to 4730 times) when the carboxylic group of 2,3-indolo-betulinic acid was сonverted to the corresponding amide. Thus, the IC50 values for glycine amide and L-phenylalanine amides were 0.04 and 0.05 μM, respectively. This study also revealed that 2,3-indolo-platanic acid is 4.5 times more active than the parent triterpenoid with IC50 of 0.4 μM. Molecular modeling suggested that improved potency is due to additional polar interactions formed between C28 side chain and a sub-pocket of the α-glucosidase allosteric site.
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Data for: SUBDUCTION CONTROL ON THE CURIE ISOTHERM AROUND THE PACIFIC-NORTH AMERICA PLATE BOUNDARY IN NORTHWESTERN MEXICO (GULF OF CALIFORNIA). PRELIMINARY RESULTS.
Contributors: Oscar Campos Enriquez, erdinc oksum, Juan-Manuel Espinosa-Cardeña
... This repository contains the raw data necesay to reproduce our results. In particular, data necesary to reproduce the results shown in Figures 5a,5b, %fc, 6a, 6b, 6c, and 7a, and 7b are included, as well as instructions how to reproduce our results.
Contributors: Jorge Hernández-García
... Data including tables (xlsx format), raw sequences (fasta format), raw and trimmed alignments (fasta format), and final phylogenetic trees.
Essential gene profiles for human pluripotent stem cells identify uncharacterized genes and substrate dependencies. Mair et al.
Contributors: Barbara Mair, Jelena Tomic, Sanna Masud, Jason Moffat
... Human pluripotent stem cells (hPSCs) provide an invaluable tool for modeling diseases and hold promise for regenerative medicine. For understanding pluripotency and lineage differentiation mechanisms, a critical first step involves systematically cataloging genes that are indispensable for hPSC maintenance and proliferation. To map genetic determinants of hPSC fitness, we performed genome-scale loss-of-function screens in an inducible Cas9 H1 hPSC line cultured on feeder cells and feeder-free to identify essential genes. Among these, we found FOXH1 and VENTX, genes that encode transcription factors previously implicated in stem cell biology, as well as an uncharacterized gene, C22orf43/DRICH1. hPSCs essential genes are substantially different from other cell lines, and gene essentiality in hPSCs is highly context-dependent with respect to different growth substrates. Our CRISPR screens establish parameters for genome-wide screens in hPSCs, which will facilitate the characterization of unappreciated regulators of hPSC biology to understand the genetic wiring of hPSC fitness and pluripotency.
Supplementary data for: Phoenix phylogeny, genetic diversity, distribution and population structure characterized in a world collection of date palm (Phoenix dactylifera) and its wild relatives
Contributors: Srinivasa Chaluvadi, Subhash N, Porter Young, Bhavesh Gajera, Bochra Amina Barhi, Kentrez Thompson, Jeff Bennetzen, Robert Krueger
... These supplementary data include Supplementary tables and plastome assemblies related to the manuscript "Phoenix phylogeny, genetic diversity, distribution and population structure characterized in a world collection of date palm (Phoenix dactylifera) and its wild relatives"
Contributors: M. Florencia Martini
... Files of DMPC-melittin and DMPC-pentalysin interaction, and different types of data analysis
Asian endemicity and the 2013 Beach Soccer World Cup: two concealed faces of recent Zika virus expansion
Contributors: Quentin Le Hingrat
... In this deposit, the dataset used for our analysis and the sequences alignment are available. We also added the xml file which can be used to re-run the phylogenetic analyses or to extract the exact conditions of our analyses.
Contributors: Gemma Owens
... Whole exome and transcriptome sequencing data for two patients with high-grade serous ovarian cancer. Data was used to identify non-synonymous somatic mutations which were predicted to give rise to neoantigens. Predicted neoantigens were filtered using peptide-MHC binding prediction algorithms. Neoantigens with a high predicted binding affinity were synthesised and screening for immunogenicity using autologous expanded TIL.