Indented polymer microparticles with shape variety reminiscent of poikilocytosis for intratumoral drug delivery after transarterial chemo-embolization
Contributors: Levinus Koole, Abderazak Benzina, Aigerim Karina, Marion Guillonneau, Samal Tazhibayeva, Haiyan Fan
... This study was conducted to explore the utility of porous embolic microspheres in transarterial embolisation (TACE) with drug-eluting embolic particles. New indented particles porous particles were found, and these show properties which are attractive for further exploration regarding widening of the clinical scope of the TACE technique .
Contributors: Stephan Harrison
... Files to support "Rock Slope Failure in the British Mountains" by David Jarman and Stephan Harrison
Contributors: Ines Diaz-Laviada, Belen Sanchez, Alicia Bort, Pedro Mateos, Nieves Rodríguez-Henche
... Data used to generate figures of the paper “Combination of the natural product capsaicin and docetaxel synergistically kills human prostate cancer cells through the metabolic regulator AMP-activated kinase” Sánchez BG, Bort A, Mateos-Gómez PA, Rodríguez-Henche N, Díaz-Laviada I. Cancer Cell Int. 2019 Mar 8;19:54. doi: 10.1186/s12935-019-0769-2. eCollection 2019. In this study we demonstrate that the spicy ingredient of peepers, capsaicin, sensitizes prostate cancer cell to docetaxel. The metabolic regulator AMPK plays a pivotal role.
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Overexpression of AMP-activated kinase sensitizes Sorafenib-resistant Hepatocellular cancer cells and decreases stem cell markers
Contributors: Ines Diaz-Laviada
... Data used to generate figures of the paper by Bort A, Sánchez BG, Mateos-Gómez PA, Vara-Ciruelos D, Rodríguez-Henche N, Díaz-Laviada I. “Targeting AMP-activated kinase impacts hepatocellular cancer stem cells induced by long-term treatment with sorafenib” Mol Oncol. 2019 May;13(5):1311-1331. doi: 10.1002/1878-0261.12488. In this study we demonstrate that the AMP-activated kinase AMPK reverse the Cancer Stem cell features of Hepatocellular CSC.
Contributors: Luca Iandoli
... The data have been used to test the following research hypotheses H1: Perceived Elegance is inversely correlated to expected effort; H2: Perceived Elegance is positively correlated with the EC of a product interface. H3: Elegance is positively correlated to the actual effort of using a new product. Perceived was elegance was measured through an online survey (see survey) in which participants were asked to rank several models of an appliance control panel in order of perceived elegance using a one to 5 scale (1 most elegant, 5 least elegant) Expected effort was measured through an online survey (see survey) in which participants were asked to rank several models of an appliance control panel in order of perceived elegance using a one to 5 scale (the easiest to use) to 5 ( the hardest to use) Effective complexity is a metric described in the file Microwave EC.ppt. The EC value is computed based on the spatial organization of control elements on the panel (knobs, buttons, screens, etc.). Actual effort was measured through total execution time of the three tasks by every participant, including possible mistakes and subsequent new attempts. The Kruskal Wallis test and post hoc test are reported in the data actual effort folder
Regional heterogeneity in gene expression, regulation and coherence in hippocampus and prefrontal cortex across development and in schizophrenia. Collado-Torres et al, Neuron, 2019.
Contributors: Leonardo Collado-Torres, Emily E Burke, Amy Peterson, Joo Heon Shin, Richard Straub, Nina Rajpurohit, Stephen A Semick, William S Ulrich, BrainSeq Consortium, Amanda J Price
... This dataset contains the Supplementary Figures and Tables for the "Regional heterogeneity in gene expression, regulation and coherence in hippocampus and prefrontal cortex across development and in schizophrenia" article by Collado-Torres et al, Neuron, 2019. Please cite the original article as well as the data itself if appropriate. For clarifications about the figures or data, please contact us by creating an issue at https://github.com/LieberInstitute/brainseq_phase2/issues. Thank you!
Data for: Marinitoga lauensis sp. nov., a novel deep-sea hydrothermal vent thermophilic anaerobic heterotroph with a prophage.
Contributors: anna-louise reysenbach, Lena Gouhier, Emily St. John
... Marinitoga lauensis sp. nov., a novel deep-sea hydrothermal vent thermophilic anaerobic heterotroph with a prophage. Stéphane L’Haridona*, Léna Gouhiera, Emily St. Johnb and Anna-Louise Reysenbachb Univ Brest, CNRS, IFREMER, Laboratoire de Microbiologie des Environnements Extrêmes, F-29280, Plouzané, Francea; Portland State University, Department of Biology and Center for Life in Extreme Environments, P.O. Box 751, Portland, OR 97207 USAb.
Contributors: Ying-Jui Hsu
... Chlorine partitioning between granitic melt and C-O-H-Cl aqueous fluids in the Earth’s upper crust, and some implications for magmatic-hydrothermal ore genesis
The NAD-booster nicotinamide riboside potently stimulates hematopoiesis through increased mitochondrial clearance
Contributors: Olaia Naveiras
... It has been recently shown that increased oxidative phosphorylation, as reflected by increased mitochondrial activity, together with impairment of the mitochondrial stress response can severely compromise hematopoietic stem cell (HSC) regeneration. Here we show that the NAD+-boosting agent Nicotinamide Riboside (NR) reduces mitochondrial activity within HSCs through increased mitochondrial clearance, leading to increased asymmetric HSC divisions. NR dietary supplementation results in a significantly enlarged pool of progenitors, without concurrent HSC exhaustion, improves survival by 80%, and accelerates blood recovery after murine lethal irradiation and limiting-HSC transplantation. In immune-deficient mice, NR increased the production of human leucocytes from hCD34+ progenitors. Our work demonstrates for the first time a positive effect of NAD+ boosting strategies on the most primitive blood stem cells, establishes a novel link between HSC mitochondrial stress, mitophagy and stem cell fate decision, and unveils the potential of NR to improve recovery of patients suffering from hematological failure including post-chemo/radiotherapy.
Data for: Access to acute care resources in various income settings to treat new-onset stroke: a survey of acute care providers
Contributors: Clint Hendrikse, Stevan Bruijns, Ramadhan Chunga
... A self-reported cross-sectional survey was conducted of delegates that attended the April 2016 International Conference on Emergency Medicine using the web-based e-Survey client, Survey Monkey Inc. The survey assessed both pre-hospital and in-hospital settings and was piloted before implementation.