Contributors: Sukhjit Sandhu
... Plant (wheat) stress analysis and classification using Image processing and machine learning models
Contributors: Hyungjun Cho, Peng Liu, Jothir Pichanndi, Taunia Closson, Daniel Majonis, Patricia Leighton, Eric Swanson, olga ornatsky, Vladimir Baranov, Mitchell Winnik
... MCP for Zr and its Use in CyTOF
Data for: Predicting missing links in directed networks based on local structure: An investment-profit index
Contributors: Jinsong Li, Shuxin Liu
... This dataset contains all necessary dataset, program files and raw results of our manuscript "Predicting missing links in directed networks based on local structure: An investment-profit index". Experiments are conduct using MATLAB software.
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Contributors: Patricia Sawamura, Nicholas Pringle
... Internal testing - Mendeley data - fake data
Data/Software for "Presynaptic Mitochondria Volumes and Complexity of Subsynaptic Distribution Increase During Development at a High-fidelity Synapse"
Contributors: Connon I. Thomas, Christian Keine, Satoko Okayama, Rachel Satterfield, Morgan Musgrove, Debbie Guerrero-Given, Naomi Kamasawa, Samuel M. Young, Jr.
... Contains data and software from the publication: "Presynaptic Mitochondria Volumes and Complexity of Subsynaptic Distribution Increase During Development at a High-fidelity Synapse" currently under review. The preprint to this data set has been published on bioRxiv (https://doi.org/10.1101/689653). In this study, we created a helper-dependent adenoviral vector (HdAd) to co-express cytoplasmic EGFP and a genetically encoded peroxidase marker (mito-APEX2) at the calyx of Held, an excellent model for deciphering regulatory mechanisms of presynaptic function. ABSTRACT: The calyx of Held, a large glutamatergic presynaptic terminal in the auditory brainstem undergoes developmental changes to support the high action-potential firing rates required for auditory information encoding. In addition, calyx terminals are morphologically diverse which impacts vesicle release properties and synaptic plasticity. Mitochondria influence synaptic plasticity through calcium buffering and are crucial for providing the energy required for synaptic transmission. Therefore, it has been postulated that mitochondrial levels increase during development and contribute to the morphological-functional diversity in the mature calyx. However, the developmental profile of mitochondrial volumes and subsynaptic distribution at the calyx of Held remains unclear. To provide insight on this, we developed a helper-dependent adenoviral vector (HdAd) that expresses the genetically encoded peroxidase marker for mitochondria, mito-APEX, at the mouse calyx of Held. We developed protocols to detect labeled mitochondria for use serial block face SEM (SBF-SEM) to carry out semi-automated segmentation of mitochondria, high-throughput whole terminal reconstruction and presynaptic ultrastructure in mice of either sex. Subsequently, we measured mitochondrial volumes and subsynaptic distributions at the immature postnatal day 7 (P7) and the mature (P21) calyx. We found an increase of mitochondria volumes in terminals and axons from P7 to P21 but did not observe differences between stalk and swelling subcompartments in the mature calyx. Based on these findings, we propose that mitochondrial volumes developmentally increase to support high firing rates but have limited contribution to morphological-functional diversity at the calyx. Data are sorted by the figures they appear in. Media (movies and 3D models) and custom-written software are located in separate folders.
Contributors: Sreetam Bhaduri, Pranab Bhattacharyya
... MATLAB program and APDL Program
Contributors: Michael Mullen
... Enclosed are the data and scripts used for the in-vivo figures in the article "Accelerated Imaging with Segmented 2D Pulses using Parallel Imaging and Virtual Coils". Details on using the scripts are found in README.txt. Running the .m files described there will re-generate Figures 4 - 8 of the article, optionally re-running the pseudo-replica algorithm.
Contributors: HAO ZHAO, Chaoping Li
... Here are two high-resolution maps for the article entitled "A Computerized Approach to Understanding Leadership Research", as well as some raw files for VOSViewer to generate interactive maps.
Contributors: Felipe Vargas Rios
... Data, figures and tables for "Sensitivity and specificity of timed Up & Go Test and falling risk in Chilean independent elderly"
Rearrangements within the U6 snRNA core during the transition between the two catalytic steps of splicing. Eysmont et al.
Contributors: Katarzyna Eysmont
... The RNA catalytic core of spliceosomes as visualized by cryo-EM remains unchanged at different stages of splicing. However, we demonstrate that mutations within the core of yeast U6 snRNA modulate conformational changes between the two catalytic steps. We propose that the intramolecular stem-loop (ISL) of U6 exists in two competing states, changing between a default, non-catalytic conformation and a transient, catalytic conformation. Whereas stable interactions in the catalytic triplex promote catalysis and their disruptions favor exit from the catalytic conformation, destabilization of the lower ISL stem promotes catalysis and its stabilization supports exit from the catalytic conformation. Thus, in addition to the catalytic triplex, U6-ISL acts as an important dynamic component of the catalytic center. The relative flexibility of the lower U6-ISL stem is conserved across eukaryotes. Similar features are found in U6atac and domain V of group II introns, arguing for the generality of the proposed mechanism.