Contributors: Yunkyoung Lee
... Lithium salts are commonly used to treat bipolar disease. Despite the frequent prescription of long-term lithium therapy, awareness of obesity, the most serious side-effect, and the mechanisms by which lithium influences lipid metabolism are largely unknown. In the present study, we gained valuable insights into the mechanisms underlying the lipogenic action of lithium by examining its effects on lipid accumulation in both cells and the zebrafish system. We have presented evidence for the first time that lithium induces lipid accumulation through stimulation of intracellular ROS generation via a GSK-3β-independent pathway. Our findings may facilitate the development of novel therapeutic targets to ameliorate side effects of lithium therapy in psychotic patients.
Contributors: Stephan Harrison
... Files to support "Rock Slope Failure in the British Mountains" by David Jarman and Stephan Harrison
Contributors: Ines Diaz-Laviada, Belen Sanchez, Alicia Bort, Pedro Mateos, Nieves Rodríguez-Henche
... Data used to generate figures of the paper “Combination of the natural product capsaicin and docetaxel synergistically kills human prostate cancer cells through the metabolic regulator AMP-activated kinase” Sánchez BG, Bort A, Mateos-Gómez PA, Rodríguez-Henche N, Díaz-Laviada I. Cancer Cell Int. 2019 Mar 8;19:54. doi: 10.1186/s12935-019-0769-2. eCollection 2019. In this study we demonstrate that the spicy ingredient of peepers, capsaicin, sensitizes prostate cancer cell to docetaxel. The metabolic regulator AMPK plays a pivotal role.
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Overexpression of AMP-activated kinase sensitizes Sorafenib-resistant Hepatocellular cancer cells and decreases stem cell markers
Contributors: Ines Diaz-Laviada
... Data used to generate figures of the paper by Bort A, Sánchez BG, Mateos-Gómez PA, Vara-Ciruelos D, Rodríguez-Henche N, Díaz-Laviada I. “Targeting AMP-activated kinase impacts hepatocellular cancer stem cells induced by long-term treatment with sorafenib” Mol Oncol. 2019 May;13(5):1311-1331. doi: 10.1002/1878-0261.12488. In this study we demonstrate that the AMP-activated kinase AMPK reverse the Cancer Stem cell features of Hepatocellular CSC.
Virtual outcrop geology comes of age: the application of consumer-grade virtual reality hardware and software to digital outcrop data analysis
Contributors: Thomas Seers, Ali Sheharyar
... In this work, the need for discipline specific analysis tools is addressed by harnessing a consumer grade virtual reality system (HTC Vive) and freeform 3D visual arts software package (Google Tilt Brush) to interactively interpret and analyze sedimentary and structural architecture (bedding contacts, faults, fractures) from digital outcrop models. Having generated these interpretations, users utilize a script library developed in the MATLABTM language to extract geologically useful data (e.g. orientation, length, intensity) from interactively generated 3D mesh patches output by Tilt Brush. Note that the submission contains the MATLAB code library, test data and presentation (.ppt) with videoed examples of Tilt Brush data input and interpretation.
Contributors: Fan Fan
... Raw data for PET-PCL blends
Contributors: Qi Cheng
... Data for this research
Data set of master thesis Applying the Requirements Engineering for Software Architecture model in software products: a case study using crowdsourcing
Contributors: Abel Menkveld
... Data gathered, used and/or analyzed for the Business Informatics Master Thesis "Applying the Requirements Engineering for Software Architecture model in software products: a case study using crowdsourcing", performed at Utrecht University.
Data for: Endothelial cell glucose metabolism is modulated by the flavonoid quercetin through actions on HIF1a signaling and energy regulating genes
Contributors: Gary Williamson, Asimina Kerimi, Sarka Tumova
... Data showing changes in HUVECs after treatment with quercetin or DMOG and assessment of gene expression, glucose uptake and protein expression.
Contributors: Luca Iandoli
... The data have been used to test the following research hypotheses H1: Perceived Elegance is inversely correlated to expected effort; H2: Perceived Elegance is positively correlated with the EC of a product interface. H3: Elegance is positively correlated to the actual effort of using a new product. Perceived was elegance was measured through an online survey (see survey) in which participants were asked to rank several models of an appliance control panel in order of perceived elegance using a one to 5 scale (1 most elegant, 5 least elegant) Expected effort was measured through an online survey (see survey) in which participants were asked to rank several models of an appliance control panel in order of perceived elegance using a one to 5 scale (the easiest to use) to 5 ( the hardest to use) Effective complexity is a metric described in the file Microwave EC.ppt. The EC value is computed based on the spatial organization of control elements on the panel (knobs, buttons, screens, etc.). Actual effort was measured through total execution time of the three tasks by every participant, including possible mistakes and subsequent new attempts. The Kruskal Wallis test and post hoc test are reported in the data actual effort folder