A study of Virus-induced changes in mRNA secondary structure uncover cis-regulatory elements that directly control gene expression. Mizrahi et al.
Contributors: Orel Mizrahi
... Unraveling cis-regulatory elements by mapping changes in mRNA structure for that reason, we measure the changes in mRNA structure using DMS-MaPseq libraries between uninfected and HCMV infected cells, and found dozens of regions in mRNAs that significantly change their structure, and have a direct role in gene expression regulation.
Raw, not cropped supporting Western blot files for: Mavrommati, I., ... Pagano, M., D'Angiolella, V.: β-TrCP- and Casein Kinase II-Mediated Degradation of Cyclin F Controls Timely Mitotic Progression. Cell Rep. (2018)
Contributors: Michele Pagano
... Raw, not cropped supporting Western blot files for: Mavrommati I, Faedda R, Galasso G, Li J, Burdova K, Fischer R, Kessler BM, Carrero ZI, Guardavaccaro D, Pagano M, D'Angiolella V. β-TrCP- and Casein Kinase II-Mediated Degradation of Cyclin F Controls Timely Mitotic Progression. Cell Rep. 2018 Sep 25;24(13):3404-3412. doi: 10.1016/j.celrep.2018.08.076. PMID: 30257202 PMCID: PMC6172692 DOI: 10.1016/j.celrep.2018.08.076
Contributors: Philipp Keller
... Guide's software and data repository- compact version
Contributors: Philipp Keller
... Guide's software and data repository- full version
Contributors: Saroj Chakraborty
... Salt-responsive Metabolite, beta-hydroxybutyrate, Attenuates Hypertension Chakraborty, S1, Galla, S1, Cheng X1, Yeo, J1, Mell, B1, Singh V1, Yeoh BS1, Saha P1, Mathew, AV2, Vijay-Kumar, M1, Joe B*1. 1Program in Physiological Genomics, Microbiome Consortium, Center for Hypertension and Personalized Medicine, Department of Physiology and Pharmacology, University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA. 2 Department of Internal Medicine-Nephrology, University of Michigan, Ann Arbor, MI, USA. *Corresponding Author: Bina Joe, firstname.lastname@example.org Summary Dietary salt reduction and exercise are lifestyle modifications prescribed for salt-sensitive hypertensives. While exercise is known to have prominent metabolic effects, such effects of lower dietary salt are just emerging. Studies indicate that salt has adverse effect on metabolic syndrome, of which, hypertension is a hallmark. We hypothesized that dietary salt impacts metabolism in a salt-sensitive model of hypertension. Untargeted metabolomic profiling of rats with differential salt (NaCl) diets revealed that a high salt-induced increase in blood pressure was associated with lower circulating levels of the ketone body, beta-hydroxybutyrate (βOHB). Specific rescue of the βOHB levels by nutritional supplementation of its precursor, 1,3-butanediol attenuated hypertension and protected kidney disease despite the high salt intake. This beneficial effect of βOHB was observed independent of the gut-microbiotal effects of salt or the Th17-mediated renal effects. Instead, the mechanism for the observed renoprotective effect of βOHB on salt-sensitive hypertension was the βOHB-mediated inhibition of the pro-inflammatory cascade by the Nlrp3 inflammasome. In summary, the juxtaposed effects of dietary salt and exercise on salt-sensitive hypertension, which decrease and increase βOHB respectively, indicates that nutritional supplementation of a precursor of βOHB could be considered to provide a similar benefit to salt-sensitive hypertension as exercise.
Contributors: Alessandro Borgognone
... Background, surgery and perspectives of the oncoplastic breast surgery are examined and discussed .
Contributors: Rola M Farid, Sherif Ashoush, Salwa Youssef
... This study examines the interaction between vitamin D deficiency (VDD) and osteopontin tissue expression in the pathogenesis of preeclampsia.
Data for: Acute upper gastrointestinal hemorrhage from a pseudoaneurysm of an unusual superior polar artery of the spleen.
Contributors: Francisco Grippi, Hyeon Yu
... Abstract: Splenic artery aneurysm and pseudoaneurysm are rare pathologies and uncommon causes of massive upper gastrointestinal bleeding. They represent the third most common intra-abdominal aneurysms. Variations in the origin of splenic artery are relatively common and asymptomatic. However, the presence of an accessory splenic artery that is symptomatic is quite atypical. In this report, we describe the case of a 73-year-old female who presented with massive upper gastrointestinal bleeding caused by a pseudoaneurysm of a superior polar artery with an unusual anatomical origin. The patient was successfully treated endovascularly with transarterial coil embolization. Early diagnosis and interventional management is crucial for patient’s survival; hence, it must be kept in mind as possible etiology of life-threatening gastrointestinal bleeding to reduce morbidity and mortality.
Contributors: Daniel Sorensen
... Raw data set for Vit 105 to titanium laser weld manuscript
Access to acute care resources in various income settings to treat new-onset stroke: a survey of acute care providers
Contributors: Clint Hendrikse, Stevan Bruijns, Ramadhan Chunga
... A self-reported cross-sectional survey was conducted of delegates that attended the April 2016 International Conference on Emergency Medicine using the web-based e-Survey client, Survey Monkey Inc. The survey assessed both pre-hospital and in-hospital settings and was piloted before implementation. The survey was distributed and opened by 955 delegates and 382 (40%) responded