Data for: Estimating the Yucca schidigera Extract Effective Level on European Seabass Juveniles (Dicentrarchus labrax) Survival, Haematological, Immunological Responses and Water Quality
Contributors: Walied Fayed, Eglal Omar, Abdallah Mansour, Basem Elkhayat, Abdelaziz Nour, Ghada Sallam, riad khalil
... One-way ANOVA; actual photos of the experimental laboratory aquaria
Indented polymer microparticles with shape variety reminiscent of poikilocytosis for intratumoral drug delivery after transarterial chemo-embolization
Contributors: Levinus Koole, Abderazak Benzina, Aigerim Karina, Marion Guillonneau, Samal Tazhibayeva, Haiyan Fan
... This study was conducted to explore the utility of porous embolic microspheres in transarterial embolisation (TACE) with drug-eluting embolic particles. New indented particles porous particles were found, and these show properties which are attractive for further exploration regarding widening of the clinical scope of the TACE technique .
Overexpression of AMP-activated kinase sensitizes Sorafenib-resistant Hepatocellular cancer cells and decreases stem cell markers
Contributors: Ines Diaz-Laviada
... Data used to generate figures of the paper by Bort A, Sánchez BG, Mateos-Gómez PA, Vara-Ciruelos D, Rodríguez-Henche N, Díaz-Laviada I. “Targeting AMP-activated kinase impacts hepatocellular cancer stem cells induced by long-term treatment with sorafenib” Mol Oncol. 2019 May;13(5):1311-1331. doi: 10.1002/1878-0261.12488. In this study we demonstrate that the AMP-activated kinase AMPK reverse the Cancer Stem cell features of Hepatocellular CSC.
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The NAD-booster nicotinamide riboside potently stimulates hematopoiesis through increased mitochondrial clearance
Contributors: Olaia Naveiras
... It has been recently shown that increased oxidative phosphorylation, as reflected by increased mitochondrial activity, together with impairment of the mitochondrial stress response can severely compromise hematopoietic stem cell (HSC) regeneration. Here we show that the NAD+-boosting agent Nicotinamide Riboside (NR) reduces mitochondrial activity within HSCs through increased mitochondrial clearance, leading to increased asymmetric HSC divisions. NR dietary supplementation results in a significantly enlarged pool of progenitors, without concurrent HSC exhaustion, improves survival by 80%, and accelerates blood recovery after murine lethal irradiation and limiting-HSC transplantation. In immune-deficient mice, NR increased the production of human leucocytes from hCD34+ progenitors. Our work demonstrates for the first time a positive effect of NAD+ boosting strategies on the most primitive blood stem cells, establishes a novel link between HSC mitochondrial stress, mitophagy and stem cell fate decision, and unveils the potential of NR to improve recovery of patients suffering from hematological failure including post-chemo/radiotherapy.
Contributors: Nicolas Sarute, Susan R Ross
... Data from to the manuscript "TRIM2, a novel member of the antiviral family, limits new world arenavirus entry"
Contributors: Petter Ström, Per Petersson, Anna Widdowson, Gennady Sergienko, Elżbieta Fortuna-Zaleśna, Marek Rubel
... ToF-ERDA data with partial GIC energy signals from QMB covers 1,2,3,5 (ILW-1-2). Data provided as list-files (.lst) and histogram files (.mpa) from FAST MPA-3 data acquisition system. ADC 1: Energy signal anode 1. ADC 2: Energy signal anodes 2-4. ADC 3: ToF signal.
Synapse-selective control of cortical maturation and plasticity by Parvalbumin-autonomous action of SynCAM 1
Contributors: Adema Ribic, Michael Crair, Thomas Biederer
... Original images used for data presentation
Raw, not cropped supporting Western blot files for: Mavrommati, I., ... Pagano, M., D'Angiolella, V.: β-TrCP- and Casein Kinase II-Mediated Degradation of Cyclin F Controls Timely Mitotic Progression. Cell Rep. (2018)
Contributors: Michele Pagano
... Raw, not cropped supporting Western blot files for: Mavrommati I, Faedda R, Galasso G, Li J, Burdova K, Fischer R, Kessler BM, Carrero ZI, Guardavaccaro D, Pagano M, D'Angiolella V. β-TrCP- and Casein Kinase II-Mediated Degradation of Cyclin F Controls Timely Mitotic Progression. Cell Rep. 2018 Sep 25;24(13):3404-3412. doi: 10.1016/j.celrep.2018.08.076. PMID: 30257202 PMCID: PMC6172692 DOI: 10.1016/j.celrep.2018.08.076
Contributors: Philipp Keller
... Guide's software and data repository- compact version