nevirapine adefovir estradiol clopidogrel venlafaxine bupropion felbamate ticlopidine spirapril aspirin felodipine opioid nifedipine statin doxorubicin rosiglitazone clomipramine abacavir caffeine omeprazole neomycin butirosin cimetidine metabolism pathway metabolic pathway toxicity xenobiotic