Cell viability tests of OVCAR-3 cells (a) and HeLa cells (b) after treated with aptamer only, SPION-CDs and APT-SPION-CDs.

Name: Cell viability tests of OVCAR-3 cells (a) and HeLa cells (b) after treated with aptamer only, SPION-CDs and APT-SPION-CDs.
Creator: mahdi asgari
Published: 2018-05-16T06:30:37.695Z
Keywords: Cytotoxicity

asgari, mahdi; Shokrani, Parvaneh; Mehrgardi, Masoud; Khanahmad, Hossein

doi:10.17632/f4838yr8y8.1

Cell viability tests of OVCAR-3 cells (a) and HeLa cells (b) after treated with aptamer only, SPION-CDs and APT-SPION-CDs.

Published: 16 May 2018| Version 1 | DOI: 10.17632/f4838yr8y8.1

Contributors:

mahdi asgari, Parvaneh Shokrani, Masoud Mehrgardi, Hossein Khanahmad

Description

the figure demonstrate that APT-SPION-CDs led to the significant decrease in toxicity for HeLa cells compare to SPION-CDs. This means that uptake of SPION-CDs was reduced in STIP1-negative cells treated with APT-SPION-CDs, so the cytotoxicity for HeLa cells would also be decreased.

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The cellular cytotoxicity of Tov6 aptamer, SPION-CDs and APT-SPION-CDs for OVCAR-3 and HeLa cells were evaluated by a standard MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide- Sigma) assay according to standard protocol.

Cell viability tests of OVCAR-3 cells (a) and HeLa cells (b) after treated with aptamer only, SPION-CDs and APT-SPION-CDs.

Description

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Steps to reproduce

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