Causal Associations Between Gut Microbiome and Cardiovascular Disease: A Mendelian Randomization Study
Observational studies have suggested associations between gut microbiome and cardiovascular diseases (CVDs), but the roles of gut microbiome remain controversial, and these associations have not yet been ascertained causally. In this article, we conduct 2-sample Mendelian randomization to investigate whether gut microbiome causally affect the risk of CVDs. We find that genus Oxalobacter was associated with an increased risk of CAD, family Clostridiaceae_1 was negatively correlated with stroke risk and ischemic stroke risk based on the locus-wide significance level. We hope this article can assist clinicians understand the beneficial or detrimental causal effects of gut microbiome components on CVDs risk and offer novel insights for exploring strategies to prevent and manage CVDs through the gut microbiome.