Journal of Ethnopharmacology

Supplementary Table 1. 99 targets of shikonin from different databases. Supplementary Table 2. 1219 genes associated with proteinuria from different databases. Supplementary Table 3. candidate targets with therapeutic glioma. Supplementary Table 4. 1083 pairs of protein interactions of candidate targets. Supplementary Table 5. specific analytical parameters of 41 central targets.

All recalculated statistics files

Supplementary data

IR (CDCl3) of Glaucacetalin E (1), 1HNMR (CDCl3, 500 MHz) of Glaucacetalin E (1), 13CNMR (CDCl3, 125 MHz) of Glaucacetalin E (1), DEPT (CDCl3, 125 MHz) of Glaucacetalin E (1), COSY (CDCl3, 500 MHz) of Glaucacetalin E (1), HSQC (CDCl3, 500 MHz) of Glaucacetalin E (1), HMBC (CDCl3, 500 MHz) of Glaucacetalin E (1), HMBC (CDCl3, 500 MHz) of Glaucacetalin E (1). IR (CDCl3) of Galphimidin B (2), 1HNMR (CDCl3, 500 MHz) of Galphimidin B (2), 13CNMR (CDCl3, 125 MHz) of Galphimidin B (2), DEPT (CDCl3, 125 MHz) of Galphimidin B (2), COSY (CDCl3, 500 MHz) of Galphimidin B (2), HSQC (CDCl3, 500 MHz) of Galphimidin B (2), HSQC (CDCl3, 500 MHz) of Galphimidin B (2), HMBC (CDCl3, 500 MHz) of Galphimidin B (2), HMBC (CDCl3, 500 MHz) of Galphimidin B (2). X-Ray crystallography of Galphimidin B (2, CCDC 1949476). Table 1S. Crystal data and structure refinement for cu_galphimin B (2, CCDC 1949476)_0m.

This is data for "Abeliophyllum distichum Nakai alleviates postmenopausal osteoporosis in ovariectomized rats and prevents RANKL-induced osteoclastogenesis in vitro" MTS, western blot, PCR etc

The pharmacological and ethnopharmacological data included refer to 64 Hypericum species distributed in China.

Background: Senecio biafrae is a medicinal plant widely used in traditional medicine to cure female infertility. Some effects have been pharmacologically demonstrated on immature female rats but in vivo and in vitro investigations are still necessary for determining its mechanism of action. The aim of the present study was to evaluate the estrogenic and FSH-like effects of the plant extracts and fractions on some fertility parameters in immature female rats and on in vitro survival and growth of swine preantral follicles.

Raw data: Anti-nociceptive and anti-inflammatory effects of the ethanol extract of Arenga pinnata (Wurmb) Merr. fruit

The influence of laboratory isolated and identified SME, ASME and IFBp, from Barleria prionitis aerial part, on the production and release of pro-inflammatory mediators i.e. myeloperoxidase (MPO), elastase, matrix metalloproteinase 9 (MMP-9), interleukin 8 (IL-8), tumor necrosis factor alpha (TNF-α) and leukotriene B4 (LTB4) was evaluated in the formyl-met-leu-phenylalanine (f-MLP) and lipopolysaccharide (LPS) stimulated human neutrophils using ELISA reader. Both SME and ASME were isolated and characterized from the IFBp. SME was isolated as white amorphous powder melted at 120–121°C with UV (MeOH) λmax, 236 nm; IR (KBr) nmax, 3404 cm–1 (–OH), 1687 cm–1 (ester carbonyl), 1645 cm–1 (enol–ether system) and positive ESI-MS, m/z (rel. int.): 835 [2M+Na]+ (8); 445 [M+K]+ (8); 429 [M+Na]+ (100), (C17H26O11 requires 406). While ASME was isolated as colorless crystals melted at 180–181°C with UV (MeOH) λmax, 235 nm; IR (KBr) nmax 3400 cm–1 (–OH), 1701 cm–1 (ester carbonyl), 1635 cm–1 (enol–ether system) and positive ESI-MS, m/z (rel. int.): 919 [2M+Na]+ (12), 487 [M+K]+ (8), and 471 [M+Na]+ (100) (C19H28O12 requires 448). Identity of SME and ASME was confirmed by comparison of their spectral analysis data (UV, FTIR, 1H NMR and 13C NMR, and positive ESI-MS) with that reported in the literature (Ghule et al., 2012; Damtoft et al., 1982; Taneja and Tiwari, 1975). Fig. 1 depicts the chemical structures of these laboratory isolated and identified compounds and the supplementary spectral data is shown in Fig. S1 (UV VIS spectra), Fig. S2 (FTIR spectra), Fig. S3 (1H-NMR spectra), Fig. S4 (13C-NMR spectra), Table S1 (1H- and 13C-NMR spectral data), Fig. S5 (positive ESI-MS spectra) of SME and ASME isolated and characterized from IFBp. Using SME and ASME as laboratory isolated and identified marker compounds of B. prionitis, a HPTLC method was validated following the guidelines of the International Conference on Harmonization.

Data File 1: Toxicity study in rat model Data File 2: Behavioural study in zebrafish model