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- Data for : Preoperative Duloxetine to Improve acute pain and quality of recovery in patients undergoing modified radical mastectomy: A dose-ranging randomized controlled trialPreoperative Duloxetine to Improve acute pain and quality of recovery in patients undergoing modified radical mastectomy: A dose-ranging randomized controlled trial Objective: Duloxetine has been recently used as a part of multimodal analgesia in perioperative settings, yet the optimal dose of Duloxetine is not determined. Design: A parallel, randomized, placebo-controlled trial. Setting: Tertiary level oncology center Patients: 88 female patients with breast cancer were subjected to modified radical mastectomy (MRM) with ASA class I and II were recruited. Intervention: Participants were randomly allocated into 4 equal groups received 2 hours preoperatively, placebo (D0, N=22), Duloxetine 30 mg (D30, N=22), Duloxetine 60 mg (D60, N=22) and Duloxetine 90 mg (D90, N=22) tablet. Measurements: The primary outcome; 24 h cumulative postoperative morphine consumption and the secondary outcomes; VAS score of pain intensity, quality of recovery (QoR-40), time to Aldrete 9, and side effects (sedation and vomiting) were measured. Results: The median (IQR) consumption of morphine (mg) in the first postoperative 24 hours was significantly decreased in both (D60 and D90) groups compared to (D0 and D30) groups, P < 0.001(Bonferroni corrected), however, a non-significant reduction was observed between D90 group vs. D60 group and D30 group vs. D0 group, P= 0.595 and P = 0.462 respectively, D60 vs. D0; 0(0-6) vs. 10(9-12), D60 vs. D30; 0(0-6) vs. 9(8-11), D90 vs. D0; 0(0-5) vs. 10(9-12), D90 vs. D30; 0(0-5) vs. 9(8-11), D90 vs. D60; 0(0-5) vs. 0(0-6), D30 vs. D0; 9(8-11) vs. 10(9-12), patients in D90 group took longer time to recover from anesthesia " time to Aldrete 9" and showed an increased level of sedation in comparison with other groups, vomiting was more frequent in the D90 group. Conclusion: Preoperative oral Duloxetine of 60 mg, for patients subjected to MRM is the optimal dose considering its analgesic efficacy and side effects.
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- Data for: Assessing the current status of continuous peripheral nerve blocks in clinical practice in North America, a survey approachThe original data of the submitted study
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- Data for: ED90 of Phenylephrine Prophylactic Bolus Dose to Prevent Maternal Hypotension after Combined Spinal and Epidural Anesthesia During Cesarean Delivery: A Sequential Dose-finding Study.The sequential of 40 patients and their results.
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- Data for: The effect of preoperative single shot Erector spinae plane vs. Paravertebra Block on patient-controlled oxycodone consumption after Video-Assisted Thoracic Surgery: a prospective non-inferiority studya prospective randomized non-inferiority study about ESPB vs. PVB in VATS.
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- Data for: Influence of the Cigarette Smoking Trend on Carboxyhemoglobin Levels in Banked Blood – An Update Fourteen Years LaterRaw data for 2004-2005 and 2017 fraction of carboxyhemoglobin level in total hemoglobin.
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- Data for: Race and Informed Consent Refusal in Research: A Retrospective Review of Clinical Trials in Surgery and AnesthesiologyDe-identified information pertaining to perioperative clinical studies at Cleveland Clinic Foundation.
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- Data for: Prediction of Postoperative Pain and Opioid Requirement in Patients Chronically Using Opioidsraw data for ' Prediction of Postoperative Pain and Opioid Requirement in Patients Chronically Using Opioids'
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- Data for: We need to rush this patient to the operating room; Outcome meta-analysis for day versus evening shift surgeryRevman 5.3 file of the included data
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- Data for: Perineural Dexamethasone Successfully Prolongs Adductor Canal Block When Assessed by Objective Pinprick Sensory Testing: A Prospective, Randomized, Dose-dependent, Placebo-controlled Equivalency TrialThis is a raw data set from our research investigating the use of perineural dexamethasone in regional anesthesia.
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- Data for: Neutrophil gelatinase-associated lipocalin (NGAL); An early urinary vs. plasma marker of acute kidney injury in intensive care unitsSPSS database for NGAL measurements and AKI
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