Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health

According to the time of onset, the severe PE patients were further divided into early onset (diagnosis of PE at < 34 weeks) PE subgroup (n = 38) and late onset (diagnosis of PE at ≥ 34 weeks) PE subgroup (n = 44). Maternal serum CypA levels were dectected in 48 severe PE patients (22 early onset PE and 26 late onset PE) and 40 healthy pregnancies by age matching method from the samples for genotyping. 40 placenta tissues from 20 severe PE patients (11 early onset PE and 9 late onset PE) and 20 age matched healthy controls were chosed for mRNA and protein detection. Clinical characteristics of these subgroups were analyzed in the supplementary tables.

Raw data of the study participants

Raw data of the study.

Methods: We conducted a prospective case control study in 50 pregnant women admitted to King George Hospital (under Andhra Medical college) Visakhapatnam India from 2012 to 2014, with gestational hypertension and preeclampsia, recruited as cases by simple random sampling. In diagnosing these hypertensive disorders NHBPEP working Group classification with modifications recommended by ACOG Task Force on Hypertension in Pregnancy was followed (6).50 normotensive pregnant women were recruited as control group and age and gestation-matched groups. All these women were in 3rd trimester of pregnancy. All women with hypertension were on antihypertensive treatment with oral labetalol or nifedipine. Women with severe hypertension were treated with either oral nifedipine and parenteral labetalol or combination. We excluded antenatal women with medical comorbidities such as chronic hypertension, heart disease, diabetes mellitus, renal disease, moderate or severe anemia and multiple pregnancy. On admission, cases and controls were assessed clinically, by appropriate laboratory work up and ultrasonography for fetal assessment. Definitions: 1. Gestational Hypertension: New onset hypertension with BP≥140/90 after 20weeks of gestation without proteinuria or end organ dysfunction 2. Preeclampsia: New onset hypertension with BP≥140/90 after 20weeks of gestation with proteinuria or end organ dysfunction 3. Severe preeclampsia /Preeclampsia with severe features as defined by ACOG Taskforce 2013.

Home blood pressure and clinic blood pressure in pregnancy

Dataset used for the paper "Age at Menarche and Blood Pressure in Pregnancy" published in Pregnancy Hypertension and containing data from the Cambridge Baby Growth Study. Uncompressed Microsoft 2013 (.xlsx) file (441 rows including header; 28 columns for standard association analysis; 1753 rows including header; 9 columns for general estimation equation modelling) containing data relevant to the publication collected as part of the Cambridge Baby Growth Study (data collection 2001-2018). All the study participants were recruited from pregnancy clinics at the Rosie Maternity Hospital, Cambridge (2001-2009) around week 15 of pregnancy (when a blood sample for the measurement of serum pregnancy-associated plasma protein A was taken by research nurses). Age at menarche, parity and record of smoking in pregnancy were self-reported and collected as part of pregnancy questionnaires. Blood pressure readings (at four time points in pregnancy), diagnoses of pre-eclampsia and offspring birth weight and gestational age at birth were collected from hospital notes. Fasting blood samples around week 28 of pregnancy were collected by research nurses. Gestational hypertension was defined as either systolic blood pressure >=140 mmHg or diastolic blood pressure >=90 mmHg in any of the blood pressure readings or was recorded from the hospital notes. Gestational hypotension was defined as <=110 mmHg and <=60 mmHg on at least any one occasion, respectively. Pregnancy-associated plasma protein A was measured by fluoroimmunoassay, insulin by enzyme-linked immunosorbent assay and glucose by a standard laboratory technique. HOMA modelling was performed using the online HOMA calculator (https://www.dtu.ox.ac.uk/homacalculator/). The index of multiple deprivation was estimated from residential post codes. Missing data are presented as empty cells. For further information about the study please contact Dr. Clive Petry (address below; email: cjp1002@cam.ac.uk). For further general information about the Cambridge Baby Growth Study please contact Dr. Carlo Acerini (Department of Paediatrics, Box 116, Addenbrooke's Hospital, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0QQ, U.K.; email: cla22@cam.ac.uk).

Data for the paper published in Pregnancy Hypertension entitled "Associations between Bacterial Infections and Blood Pressure in Pregnancy" (doi 10.1016/j.preghy.2017.09.004)