Sample Number of values Mean Std. Deviation Std. Error of Mean Lower 99% CI of mean Upper 99% CI of mean CHP2_MPL_1 371 320.9 120.5 6.256 304.7 337.1 CHP2_NRAS_3 371 718.5 223.4 11.6 688.5 748.5 CHP2_NRAS_2 371 866.1 286.8 14.89 827.6 904.6 CHP2_NRAS_1 371 629.8 230.8 11.98 598.8 660.8 CHP2_ALK_2 371 313.9 90.86 4.717 301.7 326.1 CHP2_ALK_1 371 246.2 84.89 4.407 234.8 257.6 CHP2_IDH1_1 371 771 169.9 8.819 748.1 793.8 CHP2_ERBB4_8 371 413.9 199 10.33 387.1 440.6 CHP2_ERBB4_7 371 450.4 155.1 8.054 429.6 471.3 CHP2_ERBB4_6 371 735.4 204.4 10.61 707.9 762.9 CHP2_ERBB4_5 371 208.5 94.28 4.895 195.8 221.1 CHP2_ERBB4_4 371 524.5 162.7 8.446 502.7 546.4 CHP2_ERBB4_3 371 336.3 132.5 6.879 318.5 354.1 CHP2_ERBB4_2 371 699.2 191.7 9.954 673.4 725 CHP2_ERBB4_1 371 145.3 94.48 4.905 132.6 158 CHP2_VHL_1 371 342.4 175.4 9.104 318.9 366 CHP2_VHL_2 371 442.1 104.4 5.423 428.1 456.1 CHP2_VHL_3 371 350.1 100.6 5.221 336.6 363.6 CHP2_MLH1_1 371 476.1 165.1 8.574 453.9 498.3 CHP2_CTNNB1_1 371 155.7 61.61 3.198 147.4 163.9 CHP2_PIK3CA_1 371 177.6 91.95 4.774 165.2 189.9 CHP2_PIK3CA_2 371 139.2 70.16 3.643 129.8 148.7 CHP2_PIK3CA_3 371 453.3 133.5 6.93 435.4 471.3 CHP2_PIK3CA_4 371 243.7 90.56 4.702 231.5 255.9 CHP2_PIK3CA_5 371 76.66 62.23 3.231 68.29 85.02 CHP2_PIK3CA_6 371 347.4 151.7 7.874 327.1 367.8 CHP2_PIK3CA_7 371 370.5 137.7 7.148 352 389 CHP2_PIK3CA_8 371 166.9 67.99 3.53 157.7 176 CHP2_PIK3CA_9 371 1953 749.1 38.89 1852 2053 CHP2_PIK3CA_10 371 463.5 116.2 6.035 447.9 479.1 CHP2_PIK3CA_11 371 842.4 182.7 9.484 817.9 867 CHP2_FGFR3_1 371 290.9 183.5 9.528 266.2 315.5 CHP2_FGFR3_2 371 190.2 91.34 4.742 177.9 202.5 CHP2_FGFR3_3 371 240.9 136.2 7.072 222.6 259.2 CHP2_FGFR3_4 371 397.8 259 13.44 363 432.6 CHP2_FGFR3_5 371 235.4 124.7 6.472 218.7 252.2 CHP2_PDGFRA_1 371 320.6 175 9.088 297.1 344.1 CHP2_PDGFRA_2 371 758 358.6 18.62 709.7 806.2 CHP2_PDGFRA_3 371 509 279.6 14.52 471.4 546.6 CHP2_PDGFRA_4 371 562.9 350.4 18.19 515.8 610 CHP2_KIT_1 371 535.1 216.1 11.22 506.1 564.2 CHP2_KIT_2 371 604.8 323.6 16.8 561.3 648.3 CHP2_KIT_3 371 872.1 461.7 23.97 810 934.1 CHP2_KIT_4 371 742.8 508.5 26.4 674.4 811.1 CHP2_KIT_5 371 311 204.7 10.63 283.5 338.5 CHP2_KIT_6 371 602.9 362.7 18.83 554.2 651.7 CHP2_KIT_7 371 1194 588 30.53 1115 1273 CHP2_KIT_8 371 1073 558.1 28.98 997.7 1148 CHP2_KIT_9 371 876.2 623.5 32.37 792.3 960 CHP2_KDR_9 371 203.4 122.7 6.371 186.9 219.9 CHP2_KDR_8 371 422.6 278.8 14.47 385.2 460.1 CHP2_KDR_7 371 1029 538.1 27.94 956.6 1101 CHP2_KDR_6 371 688.2 389.8 20.24 635.9 740.6 CHP2_KDR_5 371 1249 599.1 31.1 1168 1329 CHP2_KDR_4 371 592.1 291.4 15.13 553 631.3 CHP2_KDR_3 371 263.1 167.8 8.714 240.6 285.7 CHP2_KDR_2 371 510.3 262.7 13.64 475 545.6 CHP2_KDR_1 371 292 155.2 8.056 271.2 312.9 CHP2_FBXW7_5 371 727.3 305.4 15.86 686.3 768.4 CHP2_FBXW7_4 371 1146 299.7 15.56 1106 1187 CHP2_FBXW7_3 371 391.3 109 5.657 376.7 405.9 CHP2_FBXW7_2 371 734.1 301.2 15.64 693.6 774.6 CHP2_FBXW7_1 371 260.1 104.5 5.423 246.1 274.2 CHP2_APC_1 371 740 203.7 10.57 712.6 767.4 CHP2_APC_2 371 601.3 182.2 9.46 576.8 625.8 CHP2_APC_3 371 148 73.99 3.841 138.1 158 CHP2_APC_4 371 418.2 190.1 9.868 392.7 443.8 CHP2_APC_5 371 375.1 157.9 8.2 353.9 396.4 CHP2_APC_6 371 399.9 147.1 7.638 380.1 419.6 CHP2_APC_7 371 243.2 102.5 5.322 229.4 256.9 CHP2_CSF1R_2 371 474.5 151.6 7.871 454.1 494.9 CHP2_CSF1R_1 371 706.9 243.5 12.64 674.1 739.6 CHP2_NPM1_1 371 271.1 117.1 6.079 255.4 286.9 CHP2_EGFR_1 371 836.5 346.5 17.99 789.9 883.1 CHP2_EGFR_2 371 439.4 206.8 10.73 411.6 467.2 CHP2_EGFR_3 371 1311 683.1 35.47 1219 1403 CHP2_EGFR_4 371 765.1 300.1 15.58 724.7 805.4 CHP2_EGFR_5 371 438.6 256.5 13.32 404.1 473.1 CHP2_EGFR_6 371 124 74.28 3.856 114.1 134 CHP2_EGFR_7 371 376.3 209.5 10.88 348.1 404.4 CHP2_EGFR_8 371 361 200.7 10.42 334 388 CHP2_MET_1 371 1038 258.9 13.44 1003 1072 CHP2_MET_2 371 277.1 88.17 4.577 265.3 289 CHP2_MET_3 371 212.7 115.3 5.986 197.2 228.2 CHP2_MET_4 371 639.1 220.2 11.43 609.5 668.7 CHP2_MET_5 371 347.4 143.4 7.447 328.1 366.7 CHP2_MET_6 371 801.3 213.6 11.09 772.6 830 CHP2_SMO_1 371 450.3 179.7 9.33 426.1 474.4 CHP2_SMO_2 371 566.9 222.9 11.57 536.9 596.8 CHP2_SMO_3 371 498.6 213.5 11.09 469.9 527.3 CHP2_SMO_4 371 467.5 159.6 8.287 446.1 489 CHP2_SMO_5 371 483.3 203.9 10.59 455.9 510.8 CHP2_BRAF_2 371 216.5 86.36 4.483 204.9 228.1 CHP2_BRAF_1 371 195 103 5.348 181.1 208.8 CHP2_EZH2_1 371 1027 275.5 14.3 990.2 1064 CHP2_FGFR1_2 371 307.7 108.9 5.653 293.1 322.4 CHP2_FGFR1_1 371 208 85.16 4.421 196.5 219.4 CHP2_JAK2_1 371 372.9 154.1 8.003 352.2 393.6 CHP2_CDKN2A_2 371 92.61 50.48 2.621 85.82 99.39 CHP2_CDKN2A_1 371 166.5 87.57 4.546 154.8 178.3 CHP2_GNAQ_1 371 374.9 112.7 5.849 359.7 390 CHP2_ABL1_1 371 1155 615.1 31.93 1073 1238 CHP2_ABL1_2 371 687.5 276.4 14.35 650.4 724.7 CHP2_ABL1_3 371 375 320.5 16.64 331.9 418.1 CHP2_ABL1_4 371 612.7 312.1 16.2 570.8 654.7 CHP2_NOTCH1_3 371 218.4 102.6 5.326 204.6 232.2 CHP2_NOTCH1_2 371 380.3 174.2 9.044 356.9 403.8 CHP2_NOTCH1_1 371 130.6 60.08 3.119 122.6 138.7 CHP2_RET_1 371 273.4 117.6 6.106 257.6 289.2 CHP2_RET_2 371 203.6 87.73 4.555 191.9 215.4 CHP2_RET_3 371 406.8 128.8 6.688 389.5 424.1 CHP2_RET_4 371 261.6 127.2 6.604 244.5 278.7 CHP2_RET_5 371 270 101.6 5.274 256.4 283.7 CHP2_PTEN_1 371 886.9 251.3 13.04 853.1 920.6 CHP2_PTEN_2 371 92.23 74.98 3.893 82.16 102.3 CHP2_PTEN_3 371 506.6 138.5 7.19 488 525.2 CHP2_PTEN_4 371 330.3 137.6 7.143 311.8 348.8 CHP2_PTEN_5 371 396.3 133.2 6.916 378.4 414.2 CHP2_PTEN_6 371 345.9 129.9 6.746 328.4 363.3 CHP2_PTEN_7 371 598.2 312.3 16.21 556.2 640.2 CHP2_PTEN_8 371 374.9 146.1 7.585 355.2 394.5 CHP2_FGFR2_4 371 495.4 130.2 6.759 477.9 512.9 CHP2_FGFR2_3 371 397 123.9 6.435 380.4 413.7 CHP2_FGFR2_2 371 281.2 125.6 6.519 264.3 298.1 CHP2_FGFR2_1 371 340.5 89.41 4.642 328.5 352.6 CHP2_HRAS_2 371 186.3 94.03 4.882 173.7 198.9 CHP2_HRAS_1 371 362.4 132.4 6.876 344.6 380.2 CHP2_ATM_1 371 205.4 67.3 3.494 196.4 214.5 CHP2_ATM_2 371 145.2 101.6 5.273 131.6 158.9 CHP2_ATM_3 371 238.9 114.3 5.937 223.5 254.2 CHP2_ATM_4 371 879.5 209.2 10.86 851.4 907.7 CHP2_ATM_5 371 389.6 131.8 6.845 371.9 407.3 CHP2_ATM_6 371 623.1 138.1 7.169 604.5 641.7 CHP2_ATM_7 371 598.8 175.6 9.118 575.2 622.5 CHP2_ATM_8 371 1033 437.3 22.71 973.8 1091 CHP2_ATM_9 371 283 174.6 9.064 259.5 306.4 CHP2_ATM_10 371 465.6 194.3 10.09 439.5 491.7 CHP2_ATM_11 371 81.51 79.5 4.127 70.82 92.19 CHP2_ATM_12 371 769.6 186 9.655 744.6 794.5 CHP2_ATM_13 371 237.9 90.47 4.697 225.7 250.1 CHP2_ATM_14 371 167.9 82.71 4.294 156.8 179 CHP2_ATM_15 371 127.5 61.67 3.202 119.2 135.7 CHP2_ATM_16 371 667.8 154.9 8.041 647 688.6 CHP2_ATM_17 371 375.5 123.5 6.414 358.9 392.1 CHP2_KRAS_3 371 297.7 182.3 9.467 273.1 322.2 CHP2_KRAS_2 371 851 381.7 19.82 799.7 902.3 CHP2_KRAS_1 371 510.5 260.7 13.54 475.5 545.6 CHP2_PTPN11_1 371 654.5 222.4 11.55 624.6 684.4 CHP2_PTPN11_2 371 317.9 101.8 5.284 304.2 331.6 CHP2_HNF1A_1 371 541.5 165.6 8.595 519.2 563.7 CHP2_HNF1A_2 371 725.1 482.8 25.07 660.1 790 CHP2_FLT3_4 371 550.1 185.4 9.624 525.1 575 CHP2_FLT3_3 371 542.4 163.2 8.472 520.5 564.4 CHP2_FLT3_2 371 243.8 113.2 5.878 228.6 259 CHP2_FLT3_1 371 673.2 236.1 12.26 641.5 704.9 CHP2_RB1_1 371 135.6 79.37 4.12 125 146.3 CHP2_RB1_2 371 62.27 48.96 2.542 55.69 68.85 CHP2_RB1_3 371 238.1 138.1 7.168 219.5 256.6 CHP2_RB1_4 371 356.9 154.3 8.009 336.2 377.7 CHP2_RB1_5 371 289.4 134.1 6.962 271.3 307.4 CHP2_RB1_6 371 306 147.2 7.645 286.3 325.8 CHP2_RB1_7 371 294.9 175.5 9.112 271.3 318.5 CHP2_RB1_8 371 167.7 62.31 3.235 159.3 176 CHP2_RB1_9 371 34.69 33.51 1.74 30.18 39.19 CHP2_RB1_10 371 360.2 225.5 11.71 329.9 390.5 CHP2_AKT1_2 371 818.3 284.4 14.76 780.1 856.6 CHP2_AKT1_1 371 312.8 149.2 7.746 292.8 332.9 CHP2_IDH2_1 371 266.9 114.6 5.949 251.5 282.3 CHP2_CDH1_1 371 734.9 209.1 10.85 706.8 763 CHP2_CDH1_2 371 419.9 115.6 5.999 404.4 435.4 CHP2_CDH1_3 371 394.1 104.5 5.424 380.1 408.1 CHP2_TP53_8 371 363.8 94.16 4.888 351.2 376.5 CHP2_TP53_7 371 154.6 65.88 3.42 145.7 163.4 CHP2_TP53_6 371 748 229.3 11.9 717.2 778.8 CHP2_TP53_5 371 430.2 132.8 6.896 412.3 448 CHP2_TP53_4 371 342.6 148.7 7.722 322.6 362.6 CHP2_TP53_3 371 750.1 357.3 18.55 702.1 798.1 CHP2_TP53_2 371 150.3 69.06 3.585 141 159.5 CHP2_TP53_1 371 404.9 121.5 6.306 388.6 421.3 CHP2_ERBB2_1 371 505.2 800.6 41.56 397.6 612.8 CHP2_ERBB2_2 371 611.8 924.5 48 487.5 736 CHP2_ERBB2_3 371 421.2 561.3 29.14 345.8 496.7 CHP2_SMAD4_1 371 518 167.6 8.703 495.4 540.5 CHP2_SMAD4_2 371 52.74 45.21 2.347 46.67 58.82 CHP2_SMAD4_3 371 563.3 161.6 8.39 541.6 585 CHP2_SMAD4_4 371 361.3 139.1 7.223 342.6 380 CHP2_SMAD4_5 371 556 175.6 9.118 532.4 579.6 CHP2_SMAD4_6 371 469.7 138 7.163 451.1 488.2 CHP2_SMAD4_7 371 171.6 70.06 3.637 162.2 181 CHP2_SMAD4_8 371 752.3 266 13.81 716.6 788.1 CHP2_SMAD4_9 371 393.7 120.7 6.265 377.5 409.9 CHP2_STK11_1 371 474.4 212 11.01 445.9 502.9 CHP2_STK11_2 371 156.6 84.87 4.406 145.2 168 CHP2_STK11_3 371 127.1 76.77 3.986 116.8 137.5 CHP2_STK11_4 371 541.4 233.2 12.11 510.1 572.8 CHP2_STK11_5 371 243.5 93.75 4.867 230.9 256.1 CHP2_GNA11_1 371 303.9 131.1 6.804 286.3 321.5 CHP2_JAK3_3 371 159.4 66.31 3.442 150.5 168.3 CHP2_JAK3_2 371 901.4 236.1 12.26 869.7 933.1 CHP2_JAK3_1 371 259.4 122.5 6.361 242.9 275.9 CHP2_SRC_1 371 668.4 355.4 18.45 620.6 716.2 CHP2_GNAS_1 371 162.6 75.66 3.928 152.4 172.8 CHP2_GNAS_2 371 437.9 140.5 7.294 419 456.8 CHP2_SMARCB1_1 371 277 106.2 5.513 262.7 291.3 CHP2_SMARCB1_2 371 311.5 117.7 6.109 295.6 327.3 CHP2_SMARCB1_3 371 399.5 130 6.747 382.1 417 CHP2_SMARCB1_4 371 154.2 70.07 3.638 144.7 163.6 MPL 371 320.9 120.5 6.256 304.7 337.1 NRAS 371 738.1 226.4 11.76 707.7 768.6 ALK 371 280.1 81.18 4.215 269.1 291 IDH1 371 771 169.9 8.819 748.1 793.8 ERBB4 371 439.2 108.3 5.621 424.6 453.7 VHL 371 378.2 82.68 4.292 367.1 389.3 MLH1 371 476.1 165.1 8.574 453.9 498.3 CTNNB1 371 155.7 61.61 3.198 147.4 163.9 PIK3CA 371 475.8 116.9 6.071 460.1 491.5 FGFR3 371 271 141.3 7.334 252 290 PDGFRA 371 537.6 275.6 14.31 500.6 574.7 KIT 371 756.8 371.7 19.3 706.9 806.8 KDR 371 583.3 278 14.43 545.9 620.6 FBXW7 371 651.8 159.5 8.282 630.4 673.3 APC 371 418 115.1 5.975 402.5 433.4 CSF1R 371 590.7 178 9.242 566.7 614.6 NPM1 371 271.1 117.1 6.079 255.4 286.9 EGFR 371 581.5 240.5 12.48 549.1 613.8 MET 371 552.5 119 6.18 536.5 568.5 SMO 371 493.3 150.6 7.82 473.1 513.6 BRAF 371 205.7 91.05 4.727 193.5 218 EZH2 371 1027 275.5 14.3 990.2 1064 FGFR1 371 257.9 83.45 4.333 246.7 269.1 JAK2 371 372.9 154.1 8.003 352.2 393.6 CDKN2A 371 129.6 63.44 3.293 121 138.1 GNAQ 371 374.9 112.7 5.849 359.7 390 ABL1 371 707.7 328.7 17.07 663.5 751.9 NOTCH1 371 243.1 102.2 5.307 229.4 256.9 RET 371 283.1 93.17 4.837 270.6 295.6 PTEN 371 441.4 99.19 5.15 428.1 454.7 FGFR2 371 378.5 92.72 4.814 366.1 391 HRAS 371 274.3 92.58 4.807 261.9 286.8 ATM 371 428.8 91.53 4.752 416.5 441.1 KRAS 371 553.1 258.8 13.44 518.3 587.8 PTPN11 371 486.2 139.1 7.223 467.5 504.9 HNF1A 371 633.3 258.8 13.44 598.5 668.1 FLT3 371 502.4 148.4 7.702 482.4 522.3 RB1 371 224.6 93.19 4.838 212.1 237.1 AKT1 371 565.6 180.7 9.382 541.3 589.9 IDH2 371 266.9 114.6 5.949 251.5 282.3 CDH1 371 516.3 105 5.452 502.2 530.4 TP53 371 418.1 101.6 5.273 404.4 431.7 SMAD4 371 426.5 104.3 5.414 412.5 440.5 STK11 371 308.6 106.2 5.516 294.3 322.9 GNA11 371 303.9 131.1 6.804 286.3 321.5 JAK3 371 440.1 119.4 6.199 424 456.1 SRC 371 668.4 355.4 18.45 620.6 716.2 GNAS 371 300.2 90.52 4.7 288.1 312.4 SMARCB1 371 285.5 83.23 4.321 274.3 296.7 diff.EGFR2.7 371 -0.02763 0.164 0.008515 -0.04967 -0.005582 ERBB2 371 512.7 751.8 39.03 411.7 613.8