Dex vs Sufentanyl on CRP Levels in TBI

Description

Background: Traumatic brain injury (TBI) is the cause of the majority of deaths from long-term trauma and disability worldwide. Anesthesia management in TBI craniotomy requires a specific approach to optimize patient output. Dexmedetomidin is increasingly used for its neuroprotective effects. Objective: To determine the difference in C-Reactive Protein (CRP) levels in TBI patients who were given dexmedetomidin and sufentanyl who underwent craniotomy. Methods: A randomized controlled trial involved postcraniotomy TBI patients at Prof. Dr. Margono Soekarjo Hospital who met the inclusion criteria. Subjects were randomized into an intervention group that received desecedtomidin 0.3 mcg.kg-1.h-1 and a control group that received sufentanyl 0.2 mcg.kgBW-1. CRP levels were measured before, 6 hours, and 24 hours postoperatively using an immunoturbidimetric assay. Results: 50 subjects were randomized into two study groups (n=25). The basic characteristics of the two groups were found to be similar. 6-hour CRP levels (38.37 ± 6.67 vs 46.80 ± 7.50 mg.l-1; p=0.007) and 24 hours postoperatively (36.64 ± 7.26 vs 55.96 ± 6.30 mg.l-1; p<0.001) in the injective group was significantly lower than in the control group. Administration of dsmedetomidin resulted in a lower increase in CRP at each time of measurement compared to controls. Conclusions: Administration of dexmedetomidine showed significantly lower improvement in CRP levels at 6 hours and 24 hours postoperatively compared to the sufentanyl group in TBI patients undergoing craniotomy

Steps to reproduce

Characteristics in this study included age, gender, trauma onset, type of trauma, body mass index, GCS score, body temperature, length of surgery, and number of intraoperative bleeding. All patients underwent evacuation craniotomy surgery. The analysis of the characteristics of the subjects between the two groups was carried out to find out if there were differences in characteristics that could be a confounding factor in the analysis of the research output. The principle of CRP examination used is immunoturbidimetric assay. This examination quickly and accurately checks serum or plasma CRP concentrations with an automated analyzer that assesses turbidity due to antibody antigen bonds between serum CRP/plasma and anti-CRP antibodies.

Institutions

• Jenderal Soedirman University

  Central Java, Purwokerto

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