Data and code for "Gene-environment interactions explain a substantial portion of variability of common neuropsychiatric disorders"
Description
In most complex diseases, the proportion of phenotypic variability that can be explained by interactions between genetic variation and environmental stimuli (G-by-E effects) remains unknown. In this study, we study ten major neuropsychiatric disorders using data for 138 thousand US families, with nearly half a million unique individuals. We further show that, while gene-environment interactions account for only a small portion of the total phenotypic variance for a subset of disorders (depression, adjustment disorder, substance abuse), they explain a rather large quantity of the remaining disorders: over 20 percent for ADHD, migraine, and anxiety/phobic disorder, and close to 30 percent for recurrent headaches, sleep disorders, and post-traumatic stress disorder. In this study, we have incorporated – in the same analysis – clinical data, family pedigrees, the spatial distribution of individuals, their socioeconomic and demographic confounders, and a comprehensive collection of raw environmental measurements.