Desterke et al, 2020, Heterogeneity of macrophage immunoproteasome activation during lung COVID19 disease
Description
This study describe the activation of immunoproteasome components in M1 polarized macrophages at lung level during COVID19 disease. - Supplemental table 1:Table of genes implicated in MHC class I antigen presentation and found up regulated in COVID19 lung depending of SARS-COV2 virus level detected in the tissue - Supplemental Table 2: Genes found to be significant on PSMB8 cell trajectory inside CD14+/CD68+ bronchoalveolar cells from COVID19 patients - Supplemental Table 3 : Table of allele prevalence for 70 most frequent HLA-A,B,C through 20 ethnicities with worldwide distribution (USA NMDP bone marrow registry) - Supplemental Table 5: SARS-COV2 immunopeptidome against MHC class I presentation through 70 most prevalent HLA-A,B,C alleles
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Steps to reproduce
these data are connected to the associated manuscript but also with the bioinformatics code provided at the following address: https://github.com/cdesterke/covid19if