Transcriptomic Analysis Reveals Effects of Fucoxanthin on Intestinal Glucose Transport

Published: 14-06-2018| Version 1 | DOI: 10.17632/yfm7y22s88.1
Contributors:
Wanxiu Cao,
Jing Li,
Yao Xian Chin,
Robert Li,
Changhu Xue,
Qing-Juan Tang

Description

Fucoxanthin, one of carotenoid pigments from plants and algae, is known to regulate blood glucose and insulin levels. The mechanism of its hypoglycemic activity has drawn a lot of scientific interest in recent years. In this study, we investigated the effects of fucoxanthin on intestinal glucose transport using a murine model. Our data demonstrated that fucoxanthin was able to decrease blood glucose level and alleviate insulin resistance significantly. The results from RNA-seq based transcriptomic analysis, suggested that fucoxanthin acted as key regulators in Insulin/PI3K/AKT/mTOR signaling and PKA/AMPK/mTOR signaling pathways. Moreover, fucoxanthin ingestion resulted in a significant reduction in the protein expression of intestinal glucose transporters, such as SGLT-1, and led to the translocation of GLUT-2, which contributed to the regulation of blood glucose level. Together, our findings provided a mechanistic insight into the regulatory effect of fucoxanthin on blood glucose.

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