Extracellular CA1 spike trains recorded from Fmr1-null and wild-type mice during free exploration in a variety of environments that include a small and a large box, a ring, and a circular open field that is either stationary or rotating.
Contributors: Sparks, F.T., Talbot, Z.N., Dvorak, D., Fenton, A.A.
... Other (Note: This data is expected to be available before Feb 1, 2018). The data are extracellular single unit action potential, spike trains recorded from the hippocampus CA1 region of freely-behaving wild-type (WT) and Fmr1-null mice. The recordings were made using tetrodes and the Axona dacqUSB recording system, while the mice explored open field environments. Spike sorting was performed manually and single unit isolation quality was quantified using the IsoIBG and IsoINN measures (Neymotin et al., 2011). Results from these data are reported in Talbot et al., (in press), Dvorak et al., (in press) as well as BioRxiv doi: https://doi.org/10.1101/152462 and BioRxiv doi: https://doi.org/10.1101/152488, respectively.
Data related to: Layer 4 fast-spiking interneurons filter thalamocortical signals during active somatosensation. Yu, Gutnisky, Hires, Svoboda, Nature Neurosci. 2016.
Contributors: Jianing Yu, Diego Gutnisky, Samuel Andrew Hires, Karel Svoboda
... Other These experiments measure spikes and membrane potential in the mouse somatosensory thalamocortical system (Yu, Gutnisky et al Nat. Neurosci. 2016). Mice performed an active object localizatiobn behavior (as in O’Connor, D JNS 2010). Importantly, whisker movements and touch forces were tracked with millisecond time-scale precision (as in Pammer et al JNS 2013; Hires, Gutnisky et al ELife 2015). Spikes were recorded in VPM, L4 excitatory neurons, and L4 fast-spiking, parvalbumin-expressing interneurons. Importantly, L4 recordings were made with loos-seal pipettes to avoid sampling bias. Membrane potential is in addition recorded in L4 excitatory neurons and L4 fast-spiking neurons. Various optogenetic manipulations were performed to identify neuron types and to analyze the flow of excitation in the circuit.
Behavioral and electrophysiological studies of the avian thalamic song nucleus Uvaeformis including multiunit recordings in awake, behaving birds and song recordings from adult birds pre- and post-lesion of Uva.
Contributors: Husain H Danish, Dmitriy Aronov, Michale S Fee
... Other This data set contains multiunit recordings of neurons in the thalamic nucleus Uvaeformis (Uva) of adult male zebra finches (Taeniopygia gutatta) during singing (n=3 birds, >90 days post hatch). In addition, we have included song recordings from adult birds pre- and post-lesion of Uva. The results are reported in: Danish HH, Aronov D, Fee MS. Rhythmic syllable-related activity in a songbird motor thalamic nucleus necessary for learned vocalizations. PLoS One, (publication accepted) The methods that were used to collect this data are described in detail in the following protocol: Okubo TS, Mackevicius EL, Fee MS (Cold Spring Harb Protoc, 2014 Oct 23; 2014(12):1273-83)
Two photon calcium imaging recordings of spontaneous activity from mouse somatosensory cortex in wild-type and Fmr1 knock-out mice from three developmental age groups.
Contributors: Gonçalves, J.T, O’Donnell, C., Sejnowski, T.J., Portera-Cailliau, C.
... Other This dataset contains in vivo two photon Ca2+ imaging recordings obtained from Layer 2/3 somatosensory cortex of several mice of two genotypes (wild-type C57/B6 and Fmr1 knock-out) and three developmental age groups (postnatal days 9—11, 14—16, and 30—40). The mice were un-anesthetized, head-fixed, and not engaged in any experimental task. The dataset comprises: 1) the raw TIFF imaging movies, 2) estimated firing rates of individual neurons (MATLAB), and 3) the estimated anatomical distance between each pair of recorded cells (MATLAB). The number of animals in each group ranges from 6—13, while the number of simultaneously imaged neurons in each animal ranges from 40—149. Each recording was performed at a frame rate of 3.9 Hz, and the total duration of each recording is approximately 7—8 minutes.
A map of anticipatory activity in mouse motor cortex, measured with calcium imaging and silicon probes, as described in Chen et al 2017
Contributors: Tsai-Wen Chen, Nuo Li, Kayvon Daie, Karel Svoboda
... Other (This data is not yet available but is expected to be sometime during 2017).
High frequency oscillations detected in the intracranial EEG of epilepsy patients during interictal sleep, patients’ electrode location and outcome of epilepsy surgery
Contributors: Fedele T., Burnos S., Boran E., Krayenbühl N., Hilfiker P., Grunwald T., Sarnthein J.
... Other This data set contains samples of long-term invasive recordings (iEEG) from 20 patients who subsequently underwent epilepsy surgery. Recordings were made using subdural strip and grid electrodes as well as depth electrodes. From each night recording, up to six sample intervals, each containing five minutes of interictal slow-wave sleep were selected for inclusion in the data set. In the sample intervals we detected high frequency oscillations (HFO) and the start and ending times of these events are included in the data set. The HFO events were detected using a previously validated, automated algorithm (Burnos et al., 2016) in the ripple (80-250 Hz) and the fast ripple (FR, 250-500 Hz) frequency band. Contacts with the highest rate of ripples co-occurring with FR over several five-minute time intervals designated the HFO area. The motivation for collecting these data is that high frequency oscillations (HFOs) are recognized as biomarkers for epileptogenic brain tissue. A remaining challenge for epilepsy surgery is the prospective classification of tissue sampled by individual electrode contacts. For the 20 patients from which this data was collected, it was shown that resection of the prospectively defined HFO area proved to be highly specific and reproducible in 13/13 patients with seizure freedom, while it may have improved the outcome in 4/7 patients with recurrent seizures. The dataset and the results of the analysis are described in detail in (Fedele et al., 2017).
Voltage sensitive dye recording of multiple bouts of escape locomotion in the pedal ganglion of Aplysia californica
Contributors: Angela M. Bruno, William N. Frost
... Other The data set was collected from fast-voltage sensitive dye recordings of the pedal ganglion of Aplysia californica during fictive escape locomotion. The neural activity is described by spike times of isolated, single neurons. There are 30 recordings from 10 different isolated brain preparations, and each recording is 125 sec long. These data are the basis for the following paper, which contains a detailed description of the methods and results: Bruno AM, Frost WN, and Humphries MD. A spiral attractor network drives rhythmic locomotion. bioRxix. doi: 10.1101/104562, 2017.
Interspersed Distribution of Selectivity to Kinematic Stimulus Features in Supragranular Layers of Mouse Barrel Cortex.
Contributors: Francisco J. Martini, Manuel Molano-Mazón, Miguel Maravall
... Other The data contain 2-photon calcium population recordings of responses to controlled whisker stimulation in the barrel cortex of anesthetized mice. The aim was to investigate how neurons with sensitivity to different dynamic features of whisker stimuli are distributed locally across the barrel cortex. We found that nearby neurons represent diverse kinematic features, providing a rich population representation at the local scale. The results are compatible with randomly distributed selectivity to stimulus features, with no systematic additional map or ordering scheme superimposed upon the whisker map. Our data can be usefully contrasted to similar results in mouse visual and auditory cortex, and to data collected by other groups in the barrel cortex. Publication using the data: Interspersed Distribution of Selectivity to Kinematic Stimulus Features in Supragranular Layers of Mouse Barrel Cortex. Francisco J. Martini, Manuel Molano-Mazón and Miguel Maravall. Cerebral Cortex, 2017. DOI:10.1093/cercor/bhx019.
64-channel human scalp EEG from 14 unilateral PFC patients and 20 healthy controls performing a lateralized visuospatial working memory task.
Contributors: Elizabeth L. Johnson
... Other Human scalp EEG collected using a 64 + 8 channel BioSemi ActiveTwo amplifier with Ag-AgCl pin-type active electrodes mounted on an elastic cap according to the extended 10-20 system (BioSemi, Amsterdam, Netherlands), sampled at 1024 Hz. Individual data for 14 patients with unilateral prefrontal cortex lesions (mean ± SD [range]: 46 ± 16 [20-71] years of age, 15 ± 3 years of education, 6 males) and 20 age- and education-matched, healthy controls (44 ± 19 [19-70] years of age, 16 ± 3 years of education, 11 males). Primary (raw) and derived (preprocessed) EEG data, and analysis scripts included. Methods, participants, and results are described in: Johnson, E. L., Dewar, C. D., Solbakk, A-K., Endestad, T., Meling, T. R. & Knight, R. T. Bidirectional frontoparietal oscillatory systems support working memory. Current Biology (2017). doi:10.1016/j.cub.2017.05.046
Simultaneous large-scale recordings in dorsal hippocampus, basolateral amygdala and neighbouring deep nuclei and structures in rats performing a spatial aversive task and sleeping.
Contributors: G. Girardeau, I. Inema, G. Buzsaki
... Other This data set consists of simultaneous recordings from 4 rats in the dorsal hippocampus and amygdala (including BLA, CeN and neighboring nuclei and structures such as piriform cortex) during sleep and behavior. Histological reconstructions are provided as maps with corresponding structure for each electrode shank (8-shank Neuronexus silicon probes) and recording day. The behavior consists of running on a linear track for water rewards. In one location and one direction, an aversive airpuff is delivered. The location and direction change everyday in a pseudo-random manner. Each session consists of a track training session preceded and followed by sleep and rest in the homecage. At the beginning and end of each daily recording, a test is recorded with the animal running a few laps on the track without airpuff. This dataset contains - Filtered LFP files at 1250Hz (134 or 166 channels) - Sorted Spike information as given by the Neuroscope suite, klustakwik followed by manual sorting. - Videos (tracking by LED on the animal’s head) and position files. - Events for ripples, airpuffs and rewards in the Neuroscope format (.evt) - xml files for channel ordering and descriptions. The data is organized in folders per animal and session (1 session/day). A set of analysis and thorough description of the dataset and methods are described in: G. Girardeau, I. Inema, G. Buzsaki. Reactivations of emotional memory in the hippocampus-amygdala system during sleep. Nature Neuroscience (2017) doi: 10.1038/nn.4637.