Oxidative stress induced by the tetrahydrobenzimidazole TMQ0153 modulates crosstalk between apoptosis, autophagy and necroptosis in chronic myeloid leukemia (Part 3 - Figure 4 (b), Figure 5, 6, 7, Supplementary 1-5)
Contributors: Sungmi Song
... Aims: We demonstrate the capacity of the cytotoxic synthetic tetrahydrobenzimidazole (TMQ) hydroquinone (HQ) derivative TMQ0153 to induce reactive oxygen species (ROS) and mediate differential cell death modalities in chronic myeloid leukemia (CML). Results: Results showed that concentrations of TMQ0153 30 µM lead to ROS-mediated necrostatin-sensitive necroptosis. Moreover, TMQ0153 allowed us to elucidate the interplay of ROS-mediated cell death and cell stress/survival mechanisms as this compound triggers protective autophagy in response to metabolic stress in CML cells. Importantly, the modulation of cell stress prior to TMQ0153-induced cell death enhances the exposure of “find-me”/“eat-me” signals considered as hallmarks of immunogenic cell death (ICD), altogether providing a pro-oxidant therapeutic strategy against CML. Innovation: We suggest here a pro-oxidant anti-CML therapy leading to differential cell death modalities in both imatinib-sensitive and -resistant CML cell types. Moreover, we elucidated the interplay between apoptosis, autophagy and controlled necrosis induced by TMQ0153 leading to disruption of mitochondrial homeostasis. Conclusion: Our findings indicate that TMQ0153-induced ROS act as a rheostat determining the onset of apoptotic- or autophagy-related controlled necrotic cell death in CML.
Contributors: ALEN THOMAS
... The data includes the EBSD characterizations of cold rolled samples, Permeation curves from the hydrogen permeation experiment and the EDS charcterizations after the Microprint experiment
Research article manuscripts, data pieces, literature review, presentations etc on sharecropping and power-relations in villages in Sindh, Pakistan
Contributors: Ghulam Hussain
... Research article manuscripts based on research done in 2013-2014 on sharecropping, peasants and village culture in Sindh, Pakistan
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Contributors: Woon-Mok Sohn, Soon-Hyung Lee, Jong-Yil Chai, Han-Jong Rim
... In this review, we intended to reveal the infection tendency of FZT (Fishborne zoonotic trematode) metacercariae by the surveyed localities to help the further FZT studies in Laos. Although some limited points exist to show the precise epidemiological situations of ZTM (zoonotic trematode metacercariae) infections in fishes of Laos, the infection tendencies, i.e., suitable fish species, endemicities by the surveyed localities and geographical distribution pattern, of ZTM are roughly revealed in this review.
Contributors: Behzad Mohammadi
... Addition of TiO2-NPs to the polymer matrix will improve the mechanical properties of bio-polymer without having negative effect on bio-degradability. Also, a composition of CMC and TiO2-NPs in starch base polymer will result to good quality product. for this purpose, design of experiments (DOE) technique is suitable method.
Contributors: Isabel Correia, Ceyda Acilan
... Rawdata for the Data in Brief paper: "EXPERIMENTAL DATA ON NOVEL FE(III)-COMPLEXES CONTAINING PHENANTHROLINE DERIVATIVES FOR THEIR ANTICANCER PROPERTIES"
A new method for analyzing sustainability performance of global supply chains and its application to material resources
Contributors: Livia Cabernard, Stephan Pfister, Stefanie Hellweg
... VERSION 2 Compared to version 1, version 2 runs without matlab. The file “Instructions.pdf” attached below explains how to install and use this application. The file “Explanation_method_examples.pptx” attached below illustrates the principle of the method and how to use the application with several examples. OVERALL DESCRIPTION (same as for version 1): We share here the data compiled to calculate the results presented in the study «A new method for analyzing sustainability performance of global supply chains and its application to material resources». In order to allow for the compilation of all results of interest, we provide an application. This application is based on the multi-regional-input output database EXIOBASE3 (version 3.4) and data to assess the potential environmental impacts of emissions and resource use. While the data for assessing the environmental impacts is provided here, the user must download the Exiobase data from the Exiobase website (due to copyright issues). The provided application allows to assess the cumulated upstream impacts of any sector or region on the globe without double-counting and to track these impacts upstream and downstream the global value chain. The application covers a broad set of environmental and socio-economic indicators and the timespan from 1995 to 2011. The methodology of this application is comprehensively explained in the study: «A new method for analyzing sustainability performance of global supply chains and its application to material resources» (e.g Section 2.1 gives a broad overview of the principle of the method). Link to the study: https://doi.org/10.1016/j.scitotenv.2019.04.434
Port Data Penelitian Personalisasi Konten E-learning Berdasarkan Felder-Silverman Learning Style Model
Contributors: Jeremiah Hasudungan Sihombing
... Port data berikut berisi keseluruhan Data, Dokumen , Produk, dan Perangkat Lunak yang dihasilkan dari penelitian ini. Mohon untuk digunakan sebagai mana mestinya. -JHS-2019
Indented polymer microparticles with shape variety reminiscent of poikilocytosis for intratumoral drug delivery after transarterial chemo-embolization
Contributors: Levinus Koole, Abderazak Benzina, Aigerim Karina, Marion Guillonneau, Samal Tazhibayeva, Haiyan Fan
... This study was conducted to explore the utility of porous embolic microspheres in transarterial embolisation (TACE) with drug-eluting embolic particles. New indented particles porous particles were found, and these show properties which are attractive for further exploration regarding widening of the clinical scope of the TACE technique .
Contributors: Stephan Harrison
... Files to support "Rock Slope Failure in the British Mountains" by David Jarman and Stephan Harrison