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4262 results

bpm maturity grid HU 2015-2018

Contributors: paul postmes

Date: 2019-12-11

... The scan was first used in 2010 to determine the BPM maturity of organizations within the Netherlands . BPM maturity within an organization is operationalised in 37 questions (items) that measure 7 dimensions of process maturity (Process awareness, Process description, Measurement of processes, Management of processes, Process improvement, Process resources and knowledge and Information Technology). The construct of knowledge and experience of BPM is based on the personal knowledge and experience of the respondent. The respondents are asked to describe their personal knowledge on BPM. This question has four possible answers: 1) no knowledge and practical experience, 2) some knowledge, no practical experience, 3) some knowledge and a limited amount of practical experience, and 4) knowledge and practical experience.

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  • Software/Code
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Sustainability Index Software

Contributors: Hossein Abbaspour, Carsten Drebenstedt

Date: 2019-12-11

... The AHP method was developed in Java programming language and the Sustainability Index software was created to enable users to easily handle the process of selecting the best transportation system among Truck-Shovel and IPCC systems for a mine project. This software can be run just by importing the outputs of the TEcESaS Indexes software as its inputs.

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  • Software/Code(192)
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  • Document(9)
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Tetrahydrobenzimidazole TMQ0153 triggers apoptosis, autophagy and necroptosis crosstalk in chronic myeloid leukemia (Part 3 Figure 5-9, Supple 1-12))

Contributors: Sungmi Song

Date: 2019-12-10

... Abstract Chronic myeloid leukemia (CML) results from a t(9;22) (q34; q11) translocation, also called Philadelphia chromosome (Ph). This reciprocal translocation causes a constitutively-activated tyrosine kinase BCR-ABL fusion gene. By comparing imatinib-sensitive and -resistant CML cell models, we investigated the molecular mechanisms by which tetrahydrobenzimidazole derivative TMQ0153 triggered caspase-dependent apoptosis at low concentrations accompanied by loss of mitochondrial membrane potential (MMP) and increase of cytosolic free Ca2+ levels. Interestingly, at higher concentrations, TMQ0153 induced necroptotic cell death with accumulation of ROS, both preventable by N-acetyl-L-cysteine (NAC) pretreatment. At necroptosis-inducing concentrations, we observed increased ROS and decreased ATP and GSH levels, concomitant with protective autophagy induction. Inhibitors such as bafilomycin A1 (baf-A1) and siRNA against beclin 1 abrogated autophagy, sensitized CML cells against TMQ0153 and enhanced necroptotic cell death. Importantly, TMQ153-induced necrosis led to cell surface exposure of calreticulin (CRT) and ERp57 as well as the release of extracellular ATP and high mobility group box (HMGB1) demonstrating the immunological cell death markers by TMQ0153. We validated the anti-cancer potential of TMQ0153 by in vivo inhibition of K562 microtumor formation in zebrafish. Taken together, our findings provide evidence that cellular stress and redox modulation by TMQ0153 concentration-dependently leads to different cell death modalities including controlled necrosis in CML cell models.

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Tetrahydrobenzimidazole TMQ0153 triggers apoptosis, autophagy and necroptosis crosstalk in chronic myeloid leukemia- Part 2 (Figure2, 3, 4, Supple 7,8))

Contributors: Sungmi Song

Date: 2019-12-10

... Abstract Chronic myeloid leukemia (CML) results from a t(9;22) (q34; q11) translocation, also called Philadelphia chromosome (Ph). This reciprocal translocation causes a constitutively-activated tyrosine kinase BCR-ABL fusion gene. By comparing imatinib-sensitive and -resistant CML cell models, we investigated the molecular mechanisms by which tetrahydrobenzimidazole derivative TMQ0153 triggered caspase-dependent apoptosis at low concentrations accompanied by loss of mitochondrial membrane potential (MMP) and increase of cytosolic free Ca2+ levels. Interestingly, at higher concentrations, TMQ0153 induced necroptotic cell death with accumulation of ROS, both preventable by N-acetyl-L-cysteine (NAC) pretreatment. At necroptosis-inducing concentrations, we observed increased ROS and decreased ATP and GSH levels, concomitant with protective autophagy induction. Inhibitors such as bafilomycin A1 (baf-A1) and siRNA against beclin 1 abrogated autophagy, sensitized CML cells against TMQ0153 and enhanced necroptotic cell death. Importantly, TMQ153-induced necrosis led to cell surface exposure of calreticulin (CRT) and ERp57 as well as the release of extracellular ATP and high mobility group box (HMGB1) demonstrating the immunological cell death markers by TMQ0153. We validated the anti-cancer potential of TMQ0153 by in vivo inhibition of K562 microtumor formation in zebrafish. Taken together, our findings provide evidence that cellular stress and redox modulation by TMQ0153 concentration-dependently leads to different cell death modalities including controlled necrosis in CML cell models. Conclusion: Our findings indicate that TMQ0153-induced ROS act as a rheostat determining the onset of apoptotic- or autophagy-related controlled necrotic cell death in CML.

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xzss

Contributors: Mohammad Alqadi

Date: 2019-12-09

... sasasa

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  • Document(2)
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Replication data for: "Estimating the causal effect of measured endogenous variables: A tutorial on experimentally randomized instrumental variables"

Contributors: Gwendolin Sajons

Date: 2019-12-06

... This page contains all data needed to replicate the results reported in the article "Estimating the causal effect of measured endogenous variables: A tutorial on experimentally randomized instrumental variables". There are three different folders: Review, Study 1, and Study 2. The folder “Review” comprises five files: 1. The file “ERIV_review” contains the data for the Review (in .dta format), which is summarized in Table 2 of the manuscript. 2. The file “ERIV_review_code” contains the code (in .do format) to replicate the results reported in Table 2. 3. The file “ERIV_kappa” contains the data (in .dta format) that was used to calculate the kappa coefficient of inter-rater agreement. 4. The file “ERIV_kappa_code” contains the code (in .do format) to replicate the kappa coefficient reported in the description of the review. 5. The file “ERIV_review_variables” contains the description of the variables in the datasets “ERIV_review” and “ERIV_kappa” (in .pdf format). The folder “Study 1” comprises three files: 1. The file “ERIV_study1” contains the data for Study 1 (in .dta format), which was used for the analyses reported in Table 3 and Table 4 of the manuscript. 2. The file “ERIV_study1_code” contains the code (in .do format) to generate the simulated dataset as well as the code to replicate the results reported in Table 3 and Table 4. 3. The file “ERIV_ study1_variables” contains the description of the variables in the dataset “ERIV_study1” (in .pdf format). The folder “Study 2” comprises three files: 1. The file “ERIV_study2” contains the data for Study 2 (in .dta format), which was used for the analyses reported in Table 5, Table 6 and Table 7 of the manuscript. 2. The file “ERIV_study2_code” contains the code (in .do format) to replicate the results reported in Table 5, Table 6 and Table 7. 3. The file “ERIV_ study2_variables” contains the description of the variables in the dataset “ERIV_study2” (in .pdf format).

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  • Software/Code(8)
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Test three morphological methods to delineate cities

Contributors: Gaetan Montero, Cécile Tannier

Date: 2019-12-06

... Contributors: Gaëtan Montero, Cécile Tannier, Isabelle Thomas Date:2019-16-10 Description: This data set can be used to reproduce the analyses made by the authors in their paper “Morphological delineation of cities based on scaling properties of urban patterns: a comparison of three methods”. It contains 12 shapefiles that represent theoretical urban patterns and 4 shapefiles that can be used to delineate the morphological agglomeration of Brussels (Belgium). It also contains a R script to calculate the carrying capacity of a logistic percolation function. Description of each file 2_Figure_1: theoretical street network for testing the Natural Cities method 3_Figure_2: theoretical street network for the comparison of two variants of the Natural Cities method 4_Figure_3: theoretical street network to evaluate the effects of the spatial extent of the study area on the delineation of Natural Cities 5_Figure_5a: theoretical pattern for testing MorphoLim (building footprints) – dense urban core 6_Figure_5b: theoretical pattern for testing MorphoLim (building footprints) – less dense urban core 7_Figure_6: theoretical pattern (building footprints) to evaluate the effects of the geographic extent of the study area on the delineation with MorphoLim 8_Percolation_C_Calculation: R code to calculate the carrying capacity of a logistic function (Hierarchical Percolation) 9_Figure_7: theoretical street network for testing Hierarchical Percolation 10_Figure_8: theoretical polycentric street network for testing Hierarchical Percolation 11_Figure_9ac: theoretical urban pattern crossed by a large non built area (road intersections) 12_Figure_9b: theoretical urban pattern crossed by a large non built area (building footprints) 13_Figure_10ac: theoretical pattern where a built ribbon links two urban centres (roads intersections ) 14_Figure_10b: theoretical pattern where a built ribbon links two urban centres (building footprints) 15_Belgium_buildings: cadastral data of buildings (2D) for Belgium (© 2009 Administration Générale de la Documentation Patrimoniale) 16_Brabant_buildings: cadastral data of buildings (2D) for the province of Brabant (© 2009 Administration Générale de la Documentation Patrimoniale) 17_Belgium_roads: road network data come from the platform Geofabrik of OpenStreetMap (http://download.geofabrik.de, accessed 08/21/2018) for Belgium 18_Brabant_roads: Road network data come from the platform Geofabrik of OpenStreetMap (http://download.geofabrik.de, accessed 08/21/2018) for the province of Brabant.

Files:

  • Geospatial Data(32)
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  • Document(13)
  • OTHER

Dataset for "The energy and Gross Domestic Product causality nexus in Latin America 1900-2010"

Contributors: Mar Rubio-Varas, Benjamin Leiva

Date: 2019-12-04

... This dataset contains the annual modern energy consumption (the sum of coal, oil, gas, and primary electricity) of 20 Latin American countries from 1856 to year 2010. It has been built from pre-existing compilations by energy historians which have been linked to internationally available statistics after 1970. Data are expressed in terajules (TJ). This energy database is the one used by Levia and Rubio-Varas (2020)(https://doi.org/10.32479/ijeep.8670).

Files:

  • Document
  • Software/Code

Heat transfer mechanisms in fused filament fabrication

Contributors: Jie Zhang

Date: 2019-12-04

... This dataset enables temperature simulation of the fused filament fabrication(FFF) process with Matlab. Dynamic temperature fields T(x,y,z,t) subjected to 14 variables (heat capacity c(p,T), density ρ(p,T), thermal conductivity λ, nozzle temperature T_n, plate temperature T_p, air temperature above the place T_a, room temperature T_∞, nozzle diameter ϕ, part length L, part width W, part height H,layer thickness ℏ, travelling speed v, convective coefficient h) combinations become available. There will be updates on more functionality in a newer version soon. See more in the readme.pdf This algorithm also applies in a few other extrusion-temperature based additive manufacturing (AM) techniques with proper adaptations.

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  • Software/Code(9)
  • Text
  • Document

A large covariance matrix estimator under intermediate spikiness regimes

Contributors: Matteo Farnè, Angela Montanari

Date: 2019-12-04

... See the 'README.pdf' file.

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  • Software/Code(3)
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