5191068 results
Contributors: You Na Ha
Date: 2019-12-13
... Treatment of acute myeloid leukemia (AML) remains inefficient due to drug resistance and relapse, particularly in patients with FMS-like tyrosine kinase (FLT)3-internal tandem duplication (ITD). Marine-derived natural products have recently been used for drug development against AML. We show here that petromurin C, isolated from the culture extract of the marine-derived fungus Aspergillus candidus KUFA0062, which was isolated from the marine sponge Epipolasis sp., induces early autophagy followed by apoptotic cell death via activation of the intrinsic cell death pathway concomitant with mitochondrial stress and downregulation of Mcl-1 in FLT3-ITD mutated MV4-11 cells. Moreover, petromurin C synergized with the clinically-used FLT3 inhibitor gilteritinib at sub-toxic concentrations. Altogether our results suggest that petromurin C could act as an anti-leukemic agent alone or in combination with gilteritinib.
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Contributors: You Na Ha
Date: 2019-12-13
... Treatment of acute myeloid leukemia (AML) remains inefficient due to drug resistance and relapse, particularly in patients with FMS-like tyrosine kinase 3 (FLT3)-internal tandem duplication (ITD). Marine-derived natural products have recently been used for drug development against AML. We show here that petromurin C, isolated from the culture extract of the marine-derived fungus Aspergillus candidus KUFA0062, which was isolated from the marine sponge Epipolasis sp., induces early autophagy followed by apoptotic cell death via activation of the intrinsic cell death pathway concomitant with mitochondrial stress and downregulation of Mcl-1 in FLT3-ITD mutated MV4-11 cells. Moreover, petromurin C synergized with the clinically-used FLT3 inhibitor gilteritinib at sub-toxic concentrations. Altogether our results suggest that petromurin C could act as an anti-leukemic agent alone or in combination with gilteritinib.
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Contributors: Michaela Asp
Date: 2019-12-13
... High-resolution histological images with cluster coordinates, Related to Figure 2
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Top results from Data Repository sources. Show only results like these.
Contributors: You Na Ha
Date: 2019-12-13
... Treatment of acute myeloid leukemia (AML) remains inefficient due to drug resistance and relapse, particularly in patients with FMS-like tyrosine kinase 3 (FLT3)-internal tandem duplication (ITD). Marine-derived natural products have recently been used for drug development against AML. We show here that petromurin C, isolated from the culture extract of the marine-derived fungus Aspergillus candidus KUFA0062, which was isolated from the marine sponge Epipolasis sp., induces early autophagy followed by apoptotic cell death via activation of the intrinsic cell death pathway concomitant with mitochondrial stress and downregulation of Mcl-1 in FLT3-ITD mutated MV4-11 cells. Moreover, petromurin C synergized with the clinically-used FLT3 inhibitor gilteritinib at sub-toxic concentrations. Altogether our results suggest that petromurin C could act as an anti-leukemic agent alone or in combination with gilteritinib.
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Contributors: Zhanni Luo
Date: 2019-12-12
... Bibliometric analysis is an approach to analyse academic literatures based on metrics such as citations. The software HistCite helps reveal the top leading scholars, the journals in the target field, the most cited documents, key words, numbers of yearly output, document types of the published documents, language, institutions contributing in the field, and countries of the authors in the given field. The software HistCite also generates historiography which presents the relationships among the most highly cited articles.
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Contributors: Nishat Akhtar, Muhammad Rafiq Kakar
Date: 2019-12-12
... The sample image dataset comprises of high resolution image specimens of PG-76 grade based warm mix and hot mix asphalt subjected to different level of moisture sensitivity test. Moisture sensitivity stages are categorised as; dry, 1 freeze-thaw (FT) and 3 freeze-thaw (FT) cycles. The brownish area in in the image represents adhesion failure whereas the white area represents the broken aggregates. The fillers used in the asphalt mix preparation were ordinary Portland cement (OPC) and pavement modifier (PMD). The criteria for designation of each sample is provided as an attachment file (Sample Designation).
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Contributors: Hossein Abbaspour, Carsten Drebenstedt
Date: 2019-12-11
... This introduces a software called “TEcESaS Indexes”, which is produced through the Venapp tool of Vensim software. This software, which works based on system dynamics modeling, is used to model the technical, economic, environmental, safety and social factors related to the transportation systems including Truck-Shovel and IPCCs. For more details about the definition and calculation of these factors, interested readers are referred to the works done in the provided links below. For benefiting all the features of the software, you need to install Vensim DSS. However, for having partial access to some features, especially simulation, you just will need to install Vensim Reader through the following link: https://vensim.com/vensim-model-reader/
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Contributors: korawan sringarm
Date: 2019-12-11
... we compared the quality of bull frozen-thawed sexed semen after sexing sperm by cytotoxicity reaction to that of commercial sex-sorted semen using computer-assisted sperm analysis and imaging flow cytometry.
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Contributors: Fuchun Jiang
Date: 2019-12-11
... the whole uncropped image of the original western blots in this study
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Contributors: Qianghua HU
Date: 2019-12-11
... Original data for Cell Reports paper CELL-REPORTS-D-19-02836R1
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