Contributors: Andrei Novitskii
... It contains some raw data obtained during the study of phase formation mechanism for BiCuSeO based oxyselenides
Reshaping commensal gut microbiota in early life with amoxicillin presents with lower blood pressure
Contributors: Saroj Chakraborty
... Pediatric hypertension is recognized as an emerging global health concern. While new guidelines are developed for facilitating clinical management, the reasons for the prevalence of hypertension in children remain unknown. Genetics and environmental factors do not fully account for the growing incidence of pediatric hypertension. Because stable bacterial flora in early life are linked with health outcomes later in life, we hypothesized that reshaping of gut microbiota in early developmental stages of life affects blood pressure (BP) of pediatric subjects. To test this hypothesis, we administered amoxicillin, the most commonly prescribed pediatric antibiotic, to alter gut microbiota of young, genetically hypertensive rats (study 1) and dams during gestation and lactation to reshape microbiota of offspring (study 2). Reshaping of microbiota, with reductions in Firmicutes/Bacteriodetes ratio observed in Amoxicillin treated young rats and in dams. Amoxicillin treated rats also had lower blood pressure compared to the untreated rats. In the young rats treated with amoxicillin, the lowering effect on blood pressure persisted even after the antibiotics were discontinued. Similarly, the offspring from the dams treated with amoxicillin also showed lower systolic blood pressure compared to the control rats. Remarkably, in all cases, a decrease in BP was associated with lowering of Veillonellaceae, which are succinate-producing bacteria. Elevated plasma succinate is reported in hypertension. Accordingly, serum succinate was measured and found lower in animals treated with amoxicillin. Our results demonstrate a direct correlation between succinate-producing gut microbiota and early development of hypertension, and indicate that reshaping gut microbiota, especially by depleting succinate-producing microbiota early in life may have long-term benefits for hypertension-prone individuals.
Contributors: Nikola Tošić, Adam Knaack, Yahya Kurama
... This dataset contains supporting documentation explaining the use of time-dependent concrete material models TDConcrete, TDConcreteEXP, TDConcreteMC, and TDConcreteMC10NL in OpenSees. The dataset contains a manual explaining the use and features of the models, an Excel table for calculating model input parameters and example files using the material model TDConcreteMC10NL on a specific example.
Contributors: Matthias Sinnesael, Sietske J. Batenburg, Christian Zeeden, Jiri Laurin, Damien Pas, Linda Hinnov, Johannes Monkenbusch, Maximilian Vahlenkamp, Mingsong Li, Sébastien Wouters
... Supplementary materials for Submission: Sinnesael et al., Earth-Science Reviews "The Cyclostratigraphy Intercomparison Project (CIP): consistency, merits and pitfalls ".
Contributors: Guillermo Toriz, Carmen Miramontes-Corona, Alfredo Escalante, Ezequiel Delgado, Corona Gonzalez Rosa Isela, Humberto Vázquez-Torres
... Processed Data
A Mathematical Model for the Berth Allocation Problem with Variable Service Time and Continuous Time Horizon
Contributors: Bruno Luís Hönigmann Cereser
... Tests, Results and Codes of the paper "A Mathematical Model for the Berth Allocation Problem with Variable Service Time and Continuous Time Horizon".
Data/Software for "Presynaptic Mitochondria Volume and Abundance Increase During Development of a High-Fidelity Synapse"
Contributors: Connon I. Thomas, Christian Keine, Satoko Okayama, Rachel Satterfield, Morgan Musgrove, Debbie Guerrero-Given, Naomi Kamasawa, Samuel M. Young, Jr.
... Contains data and software from the publication: "Presynaptic Mitochondria Volume and Abundance Increase During Development of a High-Fidelity Synapse" published in the The Journal of Neuroscience (https://doi.org/10.1523/JNEUROSCI.0363-19.2019). The preprint to this data set has been published on bioRxiv (https://doi.org/10.1101/689653). In this study, we created a helper-dependent adenoviral vector (HdAd) to co-express cytoplasmic EGFP and a genetically encoded peroxidase marker (mito-APEX2) at the calyx of Held, an excellent model for deciphering regulatory mechanisms of presynaptic function. ABSTRACT: The calyx of Held, a large glutamatergic presynaptic terminal in the auditory brainstem undergoes developmental changes to support the high action-potential firing rates required for auditory information encoding. In addition, calyx terminals are morphologically diverse which impacts vesicle release properties and synaptic plasticity. Mitochondria influence synaptic plasticity through calcium buffering and are crucial for providing the energy required for synaptic transmission. Therefore, it has been postulated that mitochondrial levels increase during development and contribute to the morphological-functional diversity in the mature calyx. However, the developmental profile of mitochondrial volumes and subsynaptic distribution at the calyx of Held remains unclear. To provide insight on this, we developed a helper-dependent adenoviral vector (HdAd) that expresses the genetically encoded peroxidase marker for mitochondria, mito-APEX2, at the mouse calyx of Held. We developed protocols to detect labeled mitochondria for use with serial block face scanning electron microscopy to carry out semi-automated segmentation of mitochondria, high-throughput whole terminal reconstruction and presynaptic ultrastructure in mice of either sex. Subsequently, we measured mitochondrial volumes and subsynaptic distributions at the immature postnatal day 7 (P7) and the mature (P21) calyx. We found an increase of mitochondria volumes in terminals and axons from P7 to P21 but did not observe differences between stalk and swelling subcompartments in the mature calyx. Based on these findings, we propose that mitochondrial volumes and synaptic localization developmentally increase to support high firing rates required in the initial stages of auditory information processing. Data are sorted by the figures they appear in. Media (movies and 3D models) and custom-written software are located in separate folders.
Contributors: Eniko Magyari
... This dataset contains the results of multi proxy analyses done on the 20 to 9 kyr cal BP section of a lake sediment core taken from Kokad Mire, E Hungary (47°24’10” N, 21°55’43” E; 112 m a.s.l.). Sediment description, pollen, microcharcoal and major element analyis results are included in the dataset. In addition, input files for quantitative climate reconstruction and output files for biomisation and summer (June-July-August) mean temperature reconstruction are provided with relevant R scripts. The aim of the study was to reconstruct vegetation change, soil development and provide quantitative climate reconstruction for the last glacial termination period for E Hungary and study the early expansion of temperate broadleaved trees (mainly Ulmus and Corylus) in the lowland of E Hungary. Our results suggest that warming was most intensive after Heinrich event 1, around 16,200 cal yr BP, the late glacial climate fluctuation is weakly expressed, the Younger Dryas (GS-1) do not show significant decrease in summer mean temperatures, and hazel shrubs (Corylus) expand in the area at that time confirming that this contintal area was wekly affected by this climate perturbation. The study was published in Quaternary Science Reviews. The paper is available at https://www.sciencedirect.com/science/article/pii/S0277379119305657?dgcid=author or https://doi.org/10.1016/j.quascirev.2019.105980
Contributors: Laura Newsome
... Data associated with manuscript 'Manganese and cobalt redox cycling in laterites; biogeochemical and bioprocessing implications'
Contributors: Thomas Wollmann, Haris Tabakovic
... This dataset replicates tables and figures in the article "The Impact of Money on Science." The paper measures the productivity of university research investments and asks whether the resulting pools of knowledge create valuable, downstream technology (or simply accumulate in the “ivory tower”). It uses unexpected NCAA athletic outcomes to vary research support to university faculty and estimate knowledge productivity. We find positive, significant effects of research expenditures on articles published and patents filed. Then, using data on university technology licensing income, we show that these investments produce large returns in real terms. The data consists of an instrument, inputs, and outputs (from the knowledge production process). -The instrument consists of Associated Press college football team rankings. -The inputs the knowledge production function consist of the following: * research support expenditures (downloaded from the National Science Foundation) * faculty headcounts and expenditures (also downloaded from the National Science Foundation) * physical capital, i.e. facility expenditures (downloaded from IPEDS) - The outputs measure patenting, publishing, and licensing activity * Patent data comes from PatentsView.org (http://www.patentsview.org) and the USPTO Office of the Chief Economist. * Publishing activity is measured by academic publications, mainly in the ``STEM'' fields * University technology licensing revenues are surveyed and published by Association of University Technology Managers (``AUTM'') More details on the construction of these measures can be found in the associated article. Name correspondences are provided in an Excel file (nameMerge.xlsx). Code that combines the data from the subfolders and replicates the relevant tables and figures of the paper is provided in a STATA "do" file (master_final.do). Output files are exported to the "output" subfolder.