Reshaping commensal gut microbiota in early life with amoxicillin presents with lower blood pressure
Contributors: Saroj Chakraborty
... Pediatric hypertension is recognized as an emerging global health concern. While new guidelines are developed for facilitating clinical management, the reasons for the prevalence of hypertension in children remain unknown. Genetics and environmental factors do not fully account for the growing incidence of pediatric hypertension. Because stable bacterial flora in early life are linked with health outcomes later in life, we hypothesized that reshaping of gut microbiota in early developmental stages of life affects blood pressure (BP) of pediatric subjects. To test this hypothesis, we administered amoxicillin, the most commonly prescribed pediatric antibiotic, to alter gut microbiota of young, genetically hypertensive rats (study 1) and dams during gestation and lactation to reshape microbiota of offspring (study 2). Reshaping of microbiota, with reductions in Firmicutes/Bacteriodetes ratio observed in Amoxicillin treated young rats and in dams. Amoxicillin treated rats also had lower blood pressure compared to the untreated rats. In the young rats treated with amoxicillin, the lowering effect on blood pressure persisted even after the antibiotics were discontinued. Similarly, the offspring from the dams treated with amoxicillin also showed lower systolic blood pressure compared to the control rats. Remarkably, in all cases, a decrease in BP was associated with lowering of Veillonellaceae, which are succinate-producing bacteria. Elevated plasma succinate is reported in hypertension. Accordingly, serum succinate was measured and found lower in animals treated with amoxicillin. Our results demonstrate a direct correlation between succinate-producing gut microbiota and early development of hypertension, and indicate that reshaping gut microbiota, especially by depleting succinate-producing microbiota early in life may have long-term benefits for hypertension-prone individuals.
A Mathematical Model for the Berth Allocation Problem with Variable Service Time and Continuous Time Horizon
Contributors: Bruno Luís Hönigmann Cereser
... Tests, Results and Codes of the paper "A Mathematical Model for the Berth Allocation Problem with Variable Service Time and Continuous Time Horizon".
Data/Software for "Presynaptic Mitochondria Volume and Abundance Increase During Development of a High-Fidelity Synapse"
Contributors: Connon I. Thomas, Christian Keine, Satoko Okayama, Rachel Satterfield, Morgan Musgrove, Debbie Guerrero-Given, Naomi Kamasawa, Samuel M. Young, Jr.
... Contains data and software from the publication: "Presynaptic Mitochondria Volume and Abundance Increase During Development of a High-Fidelity Synapse" published in the The Journal of Neuroscience (https://doi.org/10.1523/JNEUROSCI.0363-19.2019). The preprint to this data set has been published on bioRxiv (https://doi.org/10.1101/689653). In this study, we created a helper-dependent adenoviral vector (HdAd) to co-express cytoplasmic EGFP and a genetically encoded peroxidase marker (mito-APEX2) at the calyx of Held, an excellent model for deciphering regulatory mechanisms of presynaptic function. ABSTRACT: The calyx of Held, a large glutamatergic presynaptic terminal in the auditory brainstem undergoes developmental changes to support the high action-potential firing rates required for auditory information encoding. In addition, calyx terminals are morphologically diverse which impacts vesicle release properties and synaptic plasticity. Mitochondria influence synaptic plasticity through calcium buffering and are crucial for providing the energy required for synaptic transmission. Therefore, it has been postulated that mitochondrial levels increase during development and contribute to the morphological-functional diversity in the mature calyx. However, the developmental profile of mitochondrial volumes and subsynaptic distribution at the calyx of Held remains unclear. To provide insight on this, we developed a helper-dependent adenoviral vector (HdAd) that expresses the genetically encoded peroxidase marker for mitochondria, mito-APEX2, at the mouse calyx of Held. We developed protocols to detect labeled mitochondria for use with serial block face scanning electron microscopy to carry out semi-automated segmentation of mitochondria, high-throughput whole terminal reconstruction and presynaptic ultrastructure in mice of either sex. Subsequently, we measured mitochondrial volumes and subsynaptic distributions at the immature postnatal day 7 (P7) and the mature (P21) calyx. We found an increase of mitochondria volumes in terminals and axons from P7 to P21 but did not observe differences between stalk and swelling subcompartments in the mature calyx. Based on these findings, we propose that mitochondrial volumes and synaptic localization developmentally increase to support high firing rates required in the initial stages of auditory information processing. Data are sorted by the figures they appear in. Media (movies and 3D models) and custom-written software are located in separate folders.
Top results from Data Repository sources. Show only results like these.
A Mathematical Model for the Berth Allocation Problem with Machine Patterns and Continuous Time Horizon
Contributors: Bruno Luís Hönigmann Cereser
... Intances, codes and results.
A new method for analyzing sustainability performance of global supply chains and its application to material resources
Contributors: Livia Cabernard, Stephan Pfister, Stefanie Hellweg
... VERSION 2 Compared to version 1, version 2 runs without matlab. The file “Instructions.pdf” attached below explains how to install and use this application. The file “Explanation_method_examples.pptx” attached below illustrates the principle of the method and how to use the application with several examples. OVERALL DESCRIPTION (same as for version 1): We share here the data compiled to calculate the results presented in the study «A new method for analyzing sustainability performance of global supply chains and its application to material resources». In order to allow for the compilation of all results of interest, we provide an application. This application is based on the multi-regional-input output database EXIOBASE3 (version 3.4) and data to assess the potential environmental impacts of emissions and resource use. While the data for assessing the environmental impacts is provided here, the user must download the Exiobase data from the Exiobase website (due to copyright issues). The provided application allows to assess the cumulated upstream impacts of any sector or region on the globe without double-counting and to track these impacts upstream and downstream the global value chain. The application covers a broad set of environmental and socio-economic indicators and the timespan from 1995 to 2011. The methodology of this application is comprehensively explained in the study: «A new method for analyzing sustainability performance of global supply chains and its application to material resources» (e.g Section 2.1 gives a broad overview of the principle of the method). Link to the study: https://doi.org/10.1016/j.scitotenv.2019.04.434
Contributors: Denis Mikryukov
... Here we store the coefficients of the planetary disturbing function in computer-readable form. These were obtained by Maxima computer algebra system. The method is described by Laskar and Robutel (CMDA, 62, 193-217, 1995). We should note that our coefficients of secular Hamiltonian up to degree 4 coincide with those presented by Laskar and Robutel (see Section 7, CMDA, 62, 193-217, 1995). Therefore we hope that our expansions are error free. We plan to provide more thorough and complete comments on all of these data in the near future.
Contributors: Marsel Rabaev, Handy Pratama, Ka Ching Chan
... This data set was generated using Arena Simulation
Contributors: Denis Mikryukov
... Here we store the coefficients of the planetary disturbing function in computer-readable form. These were obtained by Maxima computer algebra system and are supposed to be used/read with the help of that system. We plan to provide more thorough and complete comments on these data in the nearest future.
Data for: Thermodynamics, electronic structure and vibrational properties of Sn(n)[S(1-x)Se(x)](m) solid solutions for energy applications
Contributors: Jonathan Skelton, David Gunn, Lee Burton, Sebastian Metz, Stephen Parker
... This repository provides additional data to accompany the paper: "Thermodynamics, Electronic Structure, and Vibrational Properties of Sn(n)[S(1–x)Se(x)](m) Solid Solutions for Energy Applications" D. S. D. Gunn, J. M. Skelton, L. A. Burton, S. Metz and S. C. Parker Chemistry of Materials 31 (10), 3672-3685 (2019), DOI: 10.1021/acs.chemmater.9b00362 This article examines the properties of four solid-solution models: Pnma and rocksalt Sn[S,Se], Sn[S,Se](2) and Sn(2)[S,Se](3). This repository makes available a full set of data for all of the ~5,000 symmetry-unique structures across the four sets of calculations, including: * Optimised structures; * Calculated total energies and degeneracies; * Calculated bandgaps and partial density of states (PDoS) curves; * Simulated dielectric functions; and * Data from lattice-dynamics calculations on selected structures. In addition, the thermodynamically averaged pair-distribution functions, PDoS curves, dielectric functions, and structural-similarity analyses presented in the paper, calculated based on a 900 K formation temperature, are also provided. Finally, the repository also contains sample input files for the Vienna Ab initio Simulation Package (VASP) code. For details of how this data was generated, viewers are referred to the published article and supporting information. Brief details of file formats and links to further documentation are given in the included README file.
Contributors: Szilárd Szabó, Boglárka Balázs, Zoltán Kovács, Balázs Deák, Ádám Kertész
... The dataset is derived from the Hungarian part of the CarpatClim database (https://doi.org/10.1002/joc.4059) and the MODIS MOD13Q1 16 days 250 m (https://doi.org/10.5067/MODIS/MOD13Q1.006) between 2000-2010, using bivariate linear regression on monthly data. The 1038 points represent 1038 R-squared (R2) values of the regressions. R2 values reflect the strength of relationship between aridity, precipitation, potential evapotranspiration, maximum temperature and the normalized vegetation index (NDVI). For spatial analysis, we provided the codes of Hungarian macro regions, land cover and topography data (terrain height, slope and aspect). Column name Description CC_ID: CarpatClim identifier Country: Country code of CarpatClim /1=Hungary/ UTM_X: X UTM Coordinate UTM_Y: Y UTM Coordinate ARIvsNDVI_R2: R2 of Aridification Index and NDVI 2000–2010 PRECvsNDVI_R2: R2 of Precipitation and NDVI 2000–2010 PETvsNDVI_R2: R2 of Potential Evapotranspiration and NDVI 2000–2010 TMAXvsNDVI_R2: R2 of Maximum Temperature and NDVI 2000–2010 DEM_slope: SRTM slope value (degree) DEM_aspect: SRTM aspect value (azimuth) DEM: SRTM elevation (m) CLC_code: CORINE Land Cover code /arable lands (211, 213,221,222, 242,243), grasslands (231, 321), forests (311, 312, 313, 324), wetlands (411, 412), water bodies (511, 512) and artificial surfaces (112, 121, 122, 131, 142) Macro_reg_code: Hunrarian Macro Region code /Great Hungarian Plain=1, Kisalföld=2, Alpokalja=3, Transdanubian Hills=4, Transdanubian Mountains=5, North-Hungarian Mountains=6/ Microregion_code: Hungarian Micro Region code (Dövényi, Z. 2010) Dövényi, Z. ed. 2010. Inventory of Natural Micro-regions of Hungary, Hungarian Academy of Sciences Geographical Institute, Budapest