Reshaping commensal gut microbiota in early life with amoxicillin presents with lower blood pressure
Contributors: Saroj Chakraborty
... Pediatric hypertension is recognized as an emerging global health concern. While new guidelines are developed for facilitating clinical management, the reasons for the prevalence of hypertension in children remain unknown. Genetics and environmental factors do not fully account for the growing incidence of pediatric hypertension. Because stable bacterial flora in early life are linked with health outcomes later in life, we hypothesized that reshaping of gut microbiota in early developmental stages of life affects blood pressure (BP) of pediatric subjects. To test this hypothesis, we administered amoxicillin, the most commonly prescribed pediatric antibiotic, to alter gut microbiota of young, genetically hypertensive rats (study 1) and dams during gestation and lactation to reshape microbiota of offspring (study 2). Reshaping of microbiota, with reductions in Firmicutes/Bacteriodetes ratio observed in Amoxicillin treated young rats and in dams. Amoxicillin treated rats also had lower blood pressure compared to the untreated rats. In the young rats treated with amoxicillin, the lowering effect on blood pressure persisted even after the antibiotics were discontinued. Similarly, the offspring from the dams treated with amoxicillin also showed lower systolic blood pressure compared to the control rats. Remarkably, in all cases, a decrease in BP was associated with lowering of Veillonellaceae, which are succinate-producing bacteria. Elevated plasma succinate is reported in hypertension. Accordingly, serum succinate was measured and found lower in animals treated with amoxicillin. Our results demonstrate a direct correlation between succinate-producing gut microbiota and early development of hypertension, and indicate that reshaping gut microbiota, especially by depleting succinate-producing microbiota early in life may have long-term benefits for hypertension-prone individuals.
Contributors: Nikola Tošić, Adam Knaack, Yahya Kurama
... This dataset contains supporting documentation explaining the use of time-dependent concrete material models TDConcrete, TDConcreteEXP, TDConcreteMC, and TDConcreteMC10NL in OpenSees. The dataset contains a manual explaining the use and features of the models, an Excel table for calculating model input parameters and example files using the material model TDConcreteMC10NL on a specific example.
Contributors: Laura Newsome
... Data associated with manuscript 'Manganese and cobalt redox cycling in laterites; biogeochemical and bioprocessing implications'
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Contributors: UnaElsLive Natra
... MD-2831 Update Java version in the Docker containers
High-Resolution 1H NMR of Powdered Solids by Homonuclear Dipolar Decoupling - Supplementary Material
Contributors: Federico Maria Paruzzo
... This folder contains the supplementary material of: Paruzzo, F.M and Emsley, L., High-Resolution 1H NMR of Powdered Solids by Homonuclear Dipolar Decoupling, J. Magn. Res. 2019. (https://doi.org/10.1016/j.jmr.2019.106598) This paper focuses on the comparison of experimental performance of homonuclear dipolar decoupling schemes, and it provides guidelines for the optimization of such experiments. This folders contains all the raw data of the experiments shown in the manuscript, as well as all the Bruker "au" and pulse programs necessary for the implementation of such experiments.
Contributors: Enrique Garcia-Macias, Alejandro E. Martínez-Castro
... All the data relating the case studies used to validate the HTSA approach. These include: simply supported beam, continuous three-span bridge, the viaduct of Rodenillo, and the viaduct of Santa Ana. Along with the data files, MATLAB scripts are also provided to post-process the results.
Data for: Phylogenetic relationship of a fossil macaque ( Macaca cf. robusta ) from the Korean Peninsula to extant species of macaques based on zygomaxillary morphology
Contributors: Tsuyoshi Ito
... Data for: Ito T, Lee YJ, Nishimura TD, Tanaka M, Woo JY, Takai M. (2018) Phylogenetic relationship of a fossil macaque ( Macaca cf. robusta ) from the Korean Peninsula to extant species of macaques based on zygomaxillary morphology. Journal of Human Evolution 119: 1-13.
Contributors: Davide Mancini
... Dataset containing historical data concerning the evolution of Little Ice Age lateral moraine in the Otemma Valley (VS, Switzerland) during the debuttressing phase since mid-1960s. Our aim was to study how the morphological and hydrological sediment connectivity of the lateral moraine responded to the progressive glacier retreat. The dataset is composed by two type of data: 1. DEMs generated using SfM photogrammetry starting from aerial imagery. These data were used to detect both morphological changes and hydrological sediment connectivity evolution during the debuttressing phase. We conclude that gullying, activated by the glacier thinning which act as hydrological base level, in the main geomorphological process determining the hydrological sediment connectivity between the lateral moraine and the proglacial plain. 2. Historical climatic data (MAAT, glacier length and accumulated snow hight during winters) since 1960 to understand how these parameters impacted the behavior of the Glacier d'Otemma over time. As the glacier d'Otemma, unlike other Alpine glacier, showed a continuous retreat since the end of the Little Ice Age we found that the morphology of the valley (very long distance between the accumulation and the ablation zone due to the low slope of the bottom) played a most important role compared to the climatic parameters.
Contributors: khalid aloufi
... Quran Dataset is a collection of different format of the Holy book of Quran. The dataset is presented in the original file in word format. also, for database application developer or researcher, the SQL files are available as well. For Semantic web application, the RDF resources are available. From the RDF files small part of the figure are developed in SVG format, which can be extended to all file using different tools to transform RDF to figure files. Another format is available , which is the CSV format , which can be used to view the data in any text editor program such as MS Excel or simple text editors. All format are made available for the help of researcher or developer.
Contributors: Kirill Mikhailov, Viatcheslav ivanenko
... Supplementary material for: Mikhailov, K.V., Ivanenko, V.N. (2019). https://doi.org/10.1016/j.ympev.2019.106574 Funding: The reanalysis of the dataset was conducted with support of the Russian Foundation for Basic Research (grants #18-04-01192).