Contributors: Juan_Gabriel Rueda-Bayona
... the folder contains input and setup files of the article An Alternative Method to Determine Extreme Hydrodynamic Forces with Data Limitations for Offshore Engineering
Contributors: Esteban Finol Berrueta
... raw DENV genomic data for Finol E. & Ooi EE. Iscience submision
Contributors: UnaElsLive Natra, mdgmatest5 live
... RDM - File Type Support 21May2019 ElsCustomer Apart from .u3d all files preview [ .obj / .ply / .vtk / .stl / .ent / .brk / .pdb / .pse / .mol / .mol2 / .cif / .u3d / .dcm / .nii] - .pse is not supported
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Database related to the seasonal variability and trend analysis of the solar energy resource in Northeastern Brazilian region.
Contributors: Frnacisco Lima, Fernando Ramos Martins, Andre Rodrigues Gonçalves, Rodrigo Santos Costa, Enio Bueno Pereira
... Database generated produced during the evaluation study on the spatial patterns, seasonal variability and trend analysis of the surface solar irradiation in the Northeastern Brazilian region by using meteorological data acquires in automated weather stations operated by the Brazilian Institute of Meteorology from 2008 till 2015.
Contributors: Jorge Hernández-García
... Data including tables (xlsx format), raw sequences (fasta format), raw and trimmed alignments (fasta format), and final phylogenetic trees.
Essential gene profiles for human pluripotent stem cells identify uncharacterized genes and substrate dependencies. Mair et al.
Contributors: Barbara Mair, Jelena Tomic, Sanna Masud, Jason Moffat
... Human pluripotent stem cells (hPSCs) provide an invaluable tool for modeling diseases and hold promise for regenerative medicine. For understanding pluripotency and lineage differentiation mechanisms, a critical first step involves systematically cataloging genes that are indispensable for hPSC maintenance and proliferation. To map genetic determinants of hPSC fitness, we performed genome-scale loss-of-function screens in an inducible Cas9 H1 hPSC line cultured on feeder cells and feeder-free to identify essential genes. Among these, we found FOXH1 and VENTX, genes that encode transcription factors previously implicated in stem cell biology, as well as an uncharacterized gene, C22orf43/DRICH1. hPSCs essential genes are substantially different from other cell lines, and gene essentiality in hPSCs is highly context-dependent with respect to different growth substrates. Our CRISPR screens establish parameters for genome-wide screens in hPSCs, which will facilitate the characterization of unappreciated regulators of hPSC biology to understand the genetic wiring of hPSC fitness and pluripotency.
Contributors: M. Florencia Martini
... Files of DMPC-melittin and DMPC-pentalysin interaction, and different types of data analysis
Asian endemicity and the 2013 Beach Soccer World Cup: two concealed faces of recent Zika virus expansion
Contributors: Quentin Le Hingrat
... In this deposit, the dataset used for our analysis and the sequences alignment are available. We also added the xml file which can be used to re-run the phylogenetic analyses or to extract the exact conditions of our analyses.
Contributors: Gemma Owens
... Whole exome and transcriptome sequencing data for two patients with high-grade serous ovarian cancer. Data was used to identify non-synonymous somatic mutations which were predicted to give rise to neoantigens. Predicted neoantigens were filtered using peptide-MHC binding prediction algorithms. Neoantigens with a high predicted binding affinity were synthesised and screening for immunogenicity using autologous expanded TIL.
Contributors: Dr. Chitra Mandal, Devawati Dutta, Chhabinath Mandal
... We have conducted molecular dynamics simulations to obtain information about the structural aspects of sialylated glycans incorporated into the OprD protein. Four N-glycosylation sites on Asn196 (NLS), Asn218 (NYT), Asn251 (NTT) and Asn288 (NGS). Out of the four sites, Asn288 site is present in the extracellular loop region having high solvent accessibility, for its proper glycosylation. Molecular dynamic studies revealed that the core glycan moiety can properly fit into Asn288 with no spatial overlap for its proper glycosylation. Simulation of sialylated-glycan in free and conjugated states depicted that the population distribution of different conformers were in good agreement with the experimental structures. The permeability of the docked antibiotic into the OprD channel revealed its binding in loop2 region and interaction with a ladder of basic amino acids helps in traversing the channel. Furthermore, we demonstrated that sialylated-glycan core structure at Asn288 blocks the channel and hinders the antibiotic binding to loop2.