Contributors: Sylvia Wirth, Pierre Baraduc, Aurélie Planté, Serge Pinède, Jean-René Duhamel
... Other The dataset is made of 189 cells recorded in the hippocampus from two Rhesus macaques. Recordings were made extracellularly with either single tungsten electrodes or 16 contact u-probes. Activity was recorded as animals were navigating via a joystick a virtual maze projected in stereo, searching for a reward. A file contains the timestamps of the action potentials, the X,Y position and camera orientation in virtual coordinates, the left and right eye X,Y coordinates, state space coordinates and task relevant event codes. Each file corresponds to a recording session of approximatively 40 minutes. We provide a few Matlab scripts and documentation that allow plotting heat maps according to position, camera orientation, state space as well as raster histograms and behavior.
Patch-clamp recordings from layer 4 pyramidal cells in guinea pig V1 acute slices showing synaptic plasticity induced by paired extracellular stimulation and spiking under both normal conditions and pharmacological GABAA blockage.
Contributors: Ignacio Sáez, Michael J. Friedlander
... Other This dataset contains patch-clamp recordings from individual pyramidal cells in layer 4 of acute slices from visual cortex area V1 in young (1-2 week old) guinea pigs. The main purpose of the experiments was to examine synaptic plasticity responses of responses evoked by electrical stimulation under normal conditions and under GABAA blockage (using bath application of bicuculline). There are three sets of data: a voltage clamp control dataset (VC, n=17), a current clamp control dataset (ICS, n=21) and a bicuculline voltage clamp dataset (VCB, n=38). Complete recordings contain a baseline of at least 10 minutes, followed by a pairing protocol in which extracellular stimulation was paired with an intracellularly-evoked (in current clamp) burst of spikes and a post-pairing epoch of at least 10 minutes. Some datasets are incomplete or were excluded from publication due to quality control (see below). This is indicated in the accompanying documentation.
Extracellular recordings in rat barrel cortex during a whisker based discrimination task of tactile stimuli that varied in whisker deflection speed at short and fast time scales.
Contributors: Leah M. McGuire, Gregory Telian, Keven Laboy-Juárez, Toshio Miyashita, Daniel J. Lee, Katherine A. Smith, Daniel E. Feldman
... Other The data set was collected from extracellular spike recordings in whisker primary somatosensory cortex (S1) of rats performing a whisker based discrimination task. Neural activity is described by the spike times of isolated single and multiunit clusters obtained from spike sorting from moveable tetrode arrays. The whisker stimuli consisted of rapid whisker impulse sequences. Each sequence (120-150 ms total duration) contained 3 brief impulses (16-26 ms each) with either Fast (F), Medium (M) or Slow (S) rise-fall velocity. Sequences had FFF, FMS, SMF or SSS order. Thus, sequences varied in whisker deflection speed at short (5-20 ms) and long (150 ms) time scales. On each trial, one stimulus was delivered, and rats discriminated stimuli in a 2-alternative forced choice task. Hence, this data set serves as a resource to explore the time scales at which cortical neurons encode whisker stimuli and how their spiking activity correlates to sensory perception. The structure contains trial information and complete neurophysiology data from 5 rats, over a total of 80 recording sessions. Neural recordings are from layer 2/3 to 6 of S1, and include both fast-spiking and regular spiking single units (identified separately). These data are the basis for the following paper, which contains a detailed description of the methods and results: Short time-scale sensory coding in S1 during discrimination of whisker vibrotactile sequences. Leah M. McGuire, Gregory Telian, Keven Laboy-Juárez, Toshio Miyashita, Daniel J. Lee, Katherine A. Smith, and Daniel E. Feldman. PLoS Biology, 2016.
Contributors: Grosmark, A.D., Long J., Buzsáki, G.
... Other This data set is composed of eight bilateral silicon-probe multi-cellular electrophysiological recordings performed on four male Long-Evans rats. These recordings were performed to assess the effect of novel spatial learning on hippocampal CA1 neural firing and LFP patterns in naïve animals. Each session consisted of a long (~4 hour) PRE rest/sleep epoch home-cage recordings performed in a familiar room, followed by a Novel MAZE running epoch (~45 minutes) in which the animals were transferred to a novel room, and water-rewarded to run on a novel maze. These mazes were either A) a wooden 1.6m linear platform, B) a wooden 1m diameter circular platform or C) a 2m metal linear platform. Animals were rewarded either at both ends of the linear platform, or at a predetermined location on the circular platform. The animal was gently encouraged to run unidirectionally on the circular platform. After the MAZE epochs the animals were transferred back to their home-cage in the familiar room where a long (~4 hour) POST rest/sleep was recorded. All eight sessions were concatenated from the PRE, MAZE, and POST recording epochs. In addition to hippocampal electrophysiological recordings, neck EMG and head-mounted accelerometer signals were recorded, and the animal’s position during MAZE running epochs was tracked via head-mounted LEDs.
Multimodal spike data recorded from posterior parietal cortex of non-human primates performing a reaction-time task involving combined eye and arm movements while in a virtual reality environment.
Contributors: Christopher A. Buneo, Ying Shi, Gregory Apker, Paul VanGilder
... Other This data was collected from the Parietal Cortex of two male rhesus macaques (macaca mulatta) using single microelectrodes. For each recording session, single-cell recordings (N=343; 219 from monkey X and 124 from monkey B) were made in the superficial cortex of the SPL (area 5), as judged by recording depth and similarity to previous recordings made in this area with standard neurophysiological techniques. Activity was recorded extracellularly with varnish-coated tungsten microelectrodes (~1- to 2-MΩ impedance at 1 kHz). Single action potentials (spikes) were isolated from the amplified and filtered (600–6,000 Hz) signal via a time-amplitude window discriminator (Plexon). Spike times were sampled at 2.5 kHz. Within a virtual reality environment where visual feedback of the limb could be manipulated, animals performed a reaction-time task involving combined eye and arm movements from a single (central) starting position to one of eight peripheral targets. Results from the experiments are described in: Shi, Y., G. Apker, and C.A. Buneo, Multimodal representation of limb endpoint position in the posterior parietal cortex. J Neurophysiol, 2013. 109(8): p. 2097-2107. DOI: 10.1152/jn.00223.2012 And another manuscript which is currently under review.
Intracellular, in vitro somatic membrane potential recordings from whole cell patch clamped rodent hippocampal CA1 neurons.
Contributors: Sang-Hun Lee, Esther Krook-Magnuson, Marianne Bezaire, Ivan Soltesz
... Other This data set contains the raw data files of current injection sweeps (generated by AxoClamp, in ATF (text) format) from somatic injections of the experimental cells (mouse and rat under standard “control” in vitro recording conditions) that were used to constrain the model cells of the model CA1 neural network published in: Marianne J. Bezaire, Ivan Raikov, Kelly Burk, Dhrumil Vyas, and Ivan Soltesz. "Interneuronal mechanisms of hippocampal theta oscillations in full-scale models of the CA1 circuit." (Under review).
Multi-unit spiking activity recorded from rat frontal cortex (brain regions mPFC, OFC, ACC, and M2) during wake-sleep episode wherein at least 7 minutes of wake are followed by 20 minutes of sleep.
Contributors: Watson, BO, Levenstein, D, Greene, JP, Gelinas, JN, Buzsáki, G
... Other Data was recorded using silicon probe electrodes in the frontal cortices of male Long Evans rats between 4-7 months of age. The design was to have no specific behavior, task or stimulus, rather the animal was left alone in it’s home cage (which it lives in at all times). Data includes both local field potentials (LFP) and spikes. 11 total animals, 27 recording sessions, 1360 total units recorded, 1121 units considered stable, 995 putative excitatory units and 126 putative inhibitory units. Only recordings including a “WAKE-SLEEP” episode wherein at least 7 minutes of wake are followed by 20 minutes of sleep. On average 2 such WAKE-SLEEP episodes per recording session.
Recordings of electrical potentials in the in vivo human brain induced by transcranial electrical stimulation
Contributors: Huang, Y., Liu, A., Lafon, B., Friedman, D., Dayan, M., Wang, X., Bikson, M., Devinsky, O., Parra, L.
... Other The data set contains the voltage magnitudes at intracranial electrodes induced by transcranial electrical stimulation (tES). It is derived from the in vivo electrocorticography (ECoG) recordings of electrical potential on human subjects when weak alternating current (smaller than 2 mA) is applied transcranially from the scalp surface. 10 individuals are recorded with almost 1400 intracranial electrodes in total covering most cortical regions and some deep brain areas. They have been used to calibrate and validate our tES models which may be published in the manuscripts referenced in the data set description. We hope these data can also be used in the future to facilitate the validation of newly developed modeling approaches for the study of tES. Also the magnetic resonance image (MRI) of each subject is included. Note that the raw ECoG recordings are not included in this data set. The voltage values in this data set are estimated by fitting a sinusoid to the recordings at each intracranial electrode. They are therefore the electrical potentials in the brain induced by the stimulation, not the spontaneous brain activities.
Single-neuron spike train recordings from macaque prefrontal cortex during a somatosensory working memory task.
Contributors: Ranulfo Romo, Carlos D. Brody, Adrián Hernández, Luis Lemus
... Other This dataset contains the recordings from prefrontal cortex of two monkeys. Both monkeys experienced the following F1 frequencies: 10 14 18 24 30 34 Hz, and each F1 frequency was paired with higher and lower F2. This dataset is published together with the following manuscript that performs dimensionality reduction of several PFC datasets: * Kobak, D., Brendel, W., Constantinidis, C., Feierstein, C. E., Kepecs, A., Mainen, Z. F., Romo, R., Qi, X.-L., Uchida, N., and Machens, C. K. (2016). Demixed principal component analysis of neural population data. eLife, in press. Original publications associated with the data are: * Romo, R., Brody, C. D., Hernández, A., and Lemus, L. (1999). Neuronal correlates of parametric working memory in the prefrontal cortex. Nature, 399(6735), 470-473. * Brody, C. D., Hernández, A., Zainos, A., and Romo, R. (2003). Timing and neural encoding of somatosensory parametric working memory in macaque prefrontal cortex. Cerebral cortex, 13(11), 1196-1207.
Data and simulations related to: Robust neuronal dynamics in premotor cortex during motor planning. Li, Daie, Svoboda, Druckman, Nature 2016.
Contributors: Nuo Li, Kayvon Daie, Karel Svoboda, Shaul Druckmann, Svoboda, Karel
... Other These experiments measure neuronal responses after transiently silencing parts of mouse premotor cortex (anterior lateral motor cortex, ALM). The data represent extracellular recordings from ALM neurons of adult mice performing pole location discrimination. Data from 91 recording sessions are included in this release. This dataset contains data from 19 mice (age > P60). 5 VGAT-ChR2-EYFP mice (Jackson laboratory, JAX Stock#014548) and 7 PV-ires-cre crossed to Rosa26-LSL-ReaChR, red-shifted channelrhodopsin reporter mice (JAX 24846), were used for simultaneous electrophysiology and photoinhibition. 7 mice (6 VGAT-ChR2-EYFP, 1 PV × ReaChR mice) were used for the callosotomy experiment. The experiments (including experiment methods) are described in the following publication: Li N, Daie K, Svoboda K, Druckmann S (2016). Robust neuronal dynamics in premotor cortex during motor planning. Nature. 7600:459-64. doi: 10.1038/nature17643