Activity of multiple neurons in the brain stem (Inferior colliculus and Pontine Nucleus) of anesthetized rats during white noise auditory stimulus
Contributors: Nir Nossenson, Ari Magal, Hagit Messer
... Other This data set consists of 20 recordings of multiunit activity from the Pontine Nucleus and Inferior Colliculus of eight anesthetized rats using either TiN electrode with 8 tips or a twisted wire tetrode. The auditory stimulus used was white noise. The stereotaxic location of the electrode in each recording, as well as electrode type are provided. The data was used to model neural activity and to compare the performance of the optimal Gaussian signal-in-Gaussian-noise (model-based) detector to that of an energy detector which is widely used in electrophysiology. The experiments, data and analysis are described in: Nir Nossenson, Ari Magal, Hagit Messer; "Detection of Stimuli from Multi-Neuron Activity: Empirical Study and Theoretical Implications", Neurocomputing (2015), http://dx.doi.org/10.1016/j.neucom.2015.10.007
Measurements of spikes in mouse VPM, barrel cortex L4 excitatory and PV neurons, as well as membrane potential measurements in L4 excitatory and PV neurons, during whisker-based object localization, as described in Yu / Gutnisky et al 2016.
Contributors: Jianing Yu, Diego Gutnisky, Karel Svoboda
... Other (This data is not yet available but will be sometime during 2016).
jRGECO1a and jRCaMP1a characterization in the intact mouse visual cortex, using AAV-based gene transfer, 2-photon imaging and loose-seal cell attached recordings, as described in Dana et al 2016
Contributors: Boaz Mohar, Hod Dana, Douglas S. Kim, Karel Svoboda, Svoboda, Karel
... Other The data contain simultaneous loose-seal, cell-attached recordings and functional imaging using red genetically-encoded calcium indicators, jRGECO1a (11 cells) and jRCaMP1a (10 cells). We recorded cells in L2/3 of the primary visual cortex in anesthetized mice watching drifting grating movie. A small field of view was imaged to acquire the highest possible SNR. We include for each cell the raw fluorescence signal from the cell soma, neuropil signal from the cell surroundings, raw electrophysiological recording data, high-pass filtered electrophysiological recording data and spikes. The contrast of the visual stimulus and the drifting grating orientation were modified during each recording to produce variety of spike rates, and is not included in the data set. Results and full description of the experiments have been published in: Sensitive red protein calcium indicators for imaging neural activity. Dana et al., eLife 2016; 10.7554/eLife.12727
Spontaneous spiking activity of hundreds of neurons in mouse somatosensory cortex slice cultures recorded using a dense 512 electrode array.
Contributors: Shinya Ito, Fang-Chin Yeh, Nicholas M. Timme, Pawel Hottowy, Alan M. Litke, John M. Beggs
... Other These data contain a record of neuron spiking activity in mouse somatosensory cortex. The recordings were performed in organotypic slice cultures after 2 to 4 weeks in vitro. The recordings were performed with a large and dense multielectrode array (512 electrodes, 60 μm interelectrode spacing, 5 μm electrode diameter, flat electrodes, roughly 1 mm by 2 mm total array area). The cultures were not stimulated, so these data represent spontaneous activity. The spiking activity was spike sorted using PCA. Details about the recording method and results from these particular data are presented in publications that are referenced in the documentation for the data. All data are stored as Matlab files using standard Matlab structures.
Simultaneous calcium imaging using GCaMP sensors and electrophysiology in L2/3 pyramidal neurons of the visual cortex in thy1 transgenic mice
Contributors: Bei-Jung Lin, Tsai-Wen Chen, Douglas S. Kim, Karel Svoboda, Svoboda, Karel
... Other (This data set is not yet available but should be sometime in late 2016, early 2017). This data set contains simultaneous calcium imaging and electrophysiology in L2/3 of the visual cortex during visual stimulations with drifting gratings. We used transgenic mouse lines GP4.3 (expressing GCaMP6s) and GP5.17 (expressing GCaMP6f) (Dana, H. et al 2014 PloS One). These mice express GCaMP6s/f under the thy-1 promoter.
Utah array extracellular recordings of spontaneous and visually evoked activity from anesthetized macaque primary visual cortex (V1).
Contributors: Kohn, A., Smith, M.A.
... Other The data comprise two conditions: spontaneous and evoked V1 activity. The data were recorded by Matthew Smith and Adam Kohn, in the Kohn lab at the Albert Einstein College of Medicine (both data sets), and J. Anthony Movshon’s lab at New York University (spontaneous data set). Tai Sing Lee (Carnegie Mellon University) provided research support and Ryan Kelly (Carnegie Mellon University) participated in the data collection and processing.
Contributors: Giulia Quattrocolo, Gianmaria Maccaferri
... Other This data set includes the raw data files from some experimental O-LM cells featured in Quattrocolo and Maccaferri (2013) that were later used to constrain the model cells of the model CA1 neural network published in Bezaire et al. (2016a).¬ Results from the experiments are described in: Giulia Quattrocolo and Gianmaria Maccaferri. Novel GABAergic circuits mediating excitation/inhibition of Cajal-Retzius cells in the developing hippocampus. The Journal of Neuroscience, 33(13):5486–5498, 2013. doi: 10.1523/JNEUROSCI.5680-12.2013
Data related to: A thalamocortical loop underlies selective persistent activity in frontal cortex Zengcai V. Guo, Hidehiko K. Inagaki, Kayvon Daie, Shaul Druckmann, Charles R. Gerfen & Karel Svoboda Nature. 2017.
Contributors: Zengcai V. Guo, Hidehiko K. Inagaki, Kayvon Daie, Shaul Druckmann, Charles R. Gerfen, Karel Svoboda
... Other (This data is not yet available but is expected to be sometime during 2017).
Simultaneous two-photon imaging and electrophysiological recordings from neurons in the mouse retina and primary visual cortex using OGB and GCamp6
Contributors: Berens, P, Theis, L., Froudarakis, E., Reimer, J., Rosón, M. R., Baden, T., Euler T., Tolias, A.S., Bethge, M.
... Other This dataset provides data from N=50 neurons measured simultaneously using two-photon calcium imaging and electrophysiology in the mouse retina and visual cortex using different recording techniques, scanning rates and indicators. Importantly, all data has been acquired under typical population recording conditions in anesthetized and awake animals. This dataset has been assembled for benchmarking spike inference algorithms described in: Theis, L., Berens, P., Froudarakis, E., Reimer, J., Rosón, M. R., Baden, T., Euler T., Tolias, A.S. and Bethge, M. (2016). Benchmarking spike rate inference in population calcium imaging. Neuron, 90(3), 471-482. doi: http://dx.doi.org/10.1016/j.neuron.2016.04.014
Calcium imaging responses from anterior lateral motor cortex (ALM) neurons of adult mice performing a tactile decision behavior.
Contributors: Chen, Tsai-Wen, Li, Nuo, Gerfen, Charles R, Guo, Zengcai V., Svoboda, Karel
... Other These dataset contains calcium imaging data from the anterior motor cortex (ALM) in mice performing a tactile delay-response task. The raw data consists of images, while the processed data consists of fluorescence transients of individual ROI, the identity of imaged cells (PT or IT), and behavioral variables (object location, licking direction etc.). The data is from four animals and includes 59 recording sessions. Results from the experiments are described in: Nuo Li, Tsai-Wen Chen, Zengcai V. Guo, Charles R. Gerfen, Karel Svoboda. A motor cortex circuit for motor planning and movement. Nature 519, 51-56 (05 March 2015) PMID: 25731172 doi: 10.1038/nature14178