Contributors: Marco Manzoni, Maddalena M Bolognesi, Asier Antoranz, Mario Faretta, Francesca M Bosisio, Giorgio Cattoretti
... Personalized immune intervention to release and redirect the T cells against a tumor has shown substantial progress in aggressive tumors such as melanoma and lung cancer, despite the fact that predictors of sustained response are still unclear. Data on less common histotypes are scanty. Among soft tissue sarcomas, uterine leiomyosarcomas (ULMS) have a dire prognosis, yet therapeutic advances are needed in order to improve the actual treatment. Immune checkpoint inhibitor therapy has been applied to exceptionally few cases, of which the immune cell composition was not examined in detail. We analyzed in situ the inflammatory infiltrate of 21 untreated ULMS in high-dimensional, single cell phenotyping on routinely processed tissue, directed at the characterization of lymphoid cells and macrophages. T-lymphoid cells displayed a composite phenotype common to all tumors, suggestive of antigen-exposure; in about half of the cases containing sufficient lymphocytes, we found evidence of exhaustion and a CD8+ TCF7+ phenotype, this latter associated with T-cell reactivation. To the contrary, myelomonocytic cells had case-specific individual combinations of phenotypes and subsets. We identified five distinct monocyte-macrophage cell types: histiocytes, phagocytes, tumor-associated macrophages, inflammatory monocytes and myelomonocytic cells of undefined phenotype. Immunosuppressive molecules (TIM3, B7H3, VISTA, PD1, PDL1) were heterogeneously expressed in inflammatory and endothelial cells. The heterogeneity and phenotype of the monocyte-macrophage population may represents a challenge for which we provide an initial understanding.
Data for: Evaluation of two crack models for reinforced concrete one-way slabs subjected to bending by means of modal tests
Contributors: Gabriel Ferreira, Roberto Pimentel, Flavio Barbosa
... Data of article
Contributors: Danilo Silva Lisboa
... This repository contains all model components (plotted as animated maps), files and Matlab codes used to construct, train and validate the Bayesian Networks model for coral bleaching forecast in the North Atlantic Ocean. In addition, we provide geographic locations maps of reef observations used by the model, broken down by the model's ability to predict them.
Contributors: Francois Lambert
... Title: Swim style-dependent utricular activation ensures gaze-stabilization during early development
Contributors: Ansar Abbas, Ririn Sari
... Spiritual leadership data set in higher education
Public Wi-Fi provision by LGAs in Australia, Wi-Fi in Australian hotels and the level of satisfaction of the hotels' customers
Contributors: Viktor Grechyn
... Dataset combining data from an Australian survey among LGA officers on public Wi-Fi provision, from www.hotelWi-Fitest.com on the speed of Wi-Fi in hotels, and from www.tripadvisor.com.au on the ranking of the Australian hotels according to four parameters: location, cleanliness, value and service
Data for the effect of upscaling procedure on terrain parameters derived from DEM: taking slope as an example
Contributors: Qianning Zhang
... This dataset contains the experimental data for scaling of DEM and slope, slope data with 9m resolution for verification, and the statistical results.
An Asian Perspective: The dataset for validation of Teachers’ Information and Communication Technology Access (TICTA)
Contributors: akhmad habibi
... This dataset aimed to be published in Data in Brief. The dataset presents the validation process of a survey of factors affecting Indonesian K-12 school teachers’ Teachers’ Information and Communication Technology Access (TICTA). The instrument was established from previous studies. It was piloted to 120 K-12 school teachers and tested for its reliability. For the main data collection, the instrument was distributed online and responded by 2775 Indonesian K-12 school teachers. The main data analysis was conducted for the measurement model using four assessments; the reflective indicator loadings, internal consistency reliability, convergent and discriminant validity. PLS-SEM was used for the analysis.
Contributors: Tetsuji Okada
... DSA files of human (N to Z, by gene name) : UniProt ID is used for a protein to which no gene name is assigned.
Contributors: Tetsuji Okada
... DSA files of E. coli (N to Z, by gene name) : UniProt ID is used for a protein to which no gene name is assigned.