10666863 results
Contributors: Gemma Nieva, Maria Dolores Braquehais, Sergi Valero
Date: 2019-07-18
... Processed data shows abstinence predictors and lapse predictors among physicians who completed the 3-step Integral Treatment Program for Addicted Physicians (ITPAP), at the Galatea Caring Program for Addicted Physcians (PAIMM).
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Contributors: Vladislav Malyshkin
Date: 2019-07-18
... This is the code to accompany the paper "On The Radon--Nikodym Spectral Approach With Optimal Clustering". This is a software implementing the algorithms of interpolation, classification, and optimal clustering based on the Lebesgue quadrature technique. Whereas in a Bayesian approach new observations change only outcome probabilities, in the Radon-Nikodym approach not only outcome probabilities but also the probability space change with new observations. This is a remarkable feature of the approach: both the probabilities and the probability space are constructed from the data. A regular PCA variation expansion depends on attributes normalizing. The PCA variation expansion in the Lebesgue quadrature basis is unique thus does not depend on attributes scale, moreover it is invariant relatively any non-degenerated linear transform of input vector components.
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Contributors: thiru S R
Date: 2019-07-17
... data
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Contributors: Hyungjun Cho, Peng Liu, Jothir Pichanndi, Taunia Closson, Daniel Majonis, Patricia Leighton, Eric Swanson, olga ornatsky, Vladimir Baranov, Mitchell Winnik
Date: 2019-07-17
... MCP for Zr and its Use in CyTOF
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Contributors: Maile Käsper, Jaan Mikk, Krista Uibu
Date: 2019-07-17
... The study investigated teachers’ teaching strategies longitudinal impact on their students´ reading outcomes and reading interest in primary grades. In the study, 220 Estonian primary school students and their 12 native language teachers from 12 schools participated. The results revealed that students’ 1st-grade reading outcomes had a positive effect on their 3rd-grade vocabulary and text comprehension results. A structural equation model showed that frequent use of teaching strategies had no longitudinal effect on students’ text comprehension but did have a negative effect on their reading interest.
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Contributors: Hiroki Oda, Yasuko Akiyama-Oda
Date: 2019-07-17
... We conducted a custom microarray experiment to detect the differences in the transcript expression levels between untreated (normal) and Pt-Delta-RNAi embryos at late stage 6 in the common house spider Parasteatoda tepidariorum. The array probes were designed based on accumulated EST and cDNA sequences. The microarray dataset has been deposited in the Gene Expression Omnibus (GEO) Database at the National Center for Biotechnology Information (NCBI) under the accession GSE113064. The expression of the transcripts selected based on the detected differences was examined in embryos by whole-mount in situ hybridization.
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Contributors: Shaokun He, Shenglian Guo
Date: 2019-07-17
... This dataset contains the basic parameters of some reservoirs in China, which are necessary for reservoir operation simulation.
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Contributors: David Alberto García Arango
Date: 2019-07-17
... Se tienen referencias bibliográficas relacionadas con el concepto de ciencia abierta y que están organizadas por continentes. Igualmente se tiene la base de datos de revistas del Diejectory of Open Access Journal (DOAJ) con información a 2017
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Contributors: Nicholas Epley, James Vandermeer, Christine Hosey, Boaz Keysar
Date: 2019-07-17
... Data from Experiments 1-7.
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Contributors: Ellen Lumpkin
Date: 2019-07-17
... Small-diameter vesicular glutamate transporter 3-lineage (Vglut3lineage) dorsal root ganglion (DRG) neurons play an important role in mechanosensation and thermal hypersensitivity; however, little is known about their intrinsic electrical properties. We therefore set out to investigate mechanisms of excitability within this population. Calcium microfluorimetry analysis demonstrated that the cooling compound menthol selectively activates a subset of Vglut3lineage neurons. Whole-cell electrophysiological recordings showed that these small-diameter Vglut3lineage DRG neurons fire menthol-evoked action potentials and exhibited robust, transient receptor potential melastatin 8 (TRPM8)-dependent discharges at room temperature. This heightened excitability was confirmed by current-clamp and action potential phase-plot analyses, which showed menthol-sensitive Vglut3lineage neurons to have more depolarized membrane potentials, lower firing thresholds, and higher evoked firing frequencies compared with menthol-insensitive Vglut3lineage neurons. A biophysical analysis revealed native voltage-gated sodium channel (NaV) currents in menthol-sensitive Vglut3lineage neurons were resistant to entry into slow inactivation compared with menthol-insensitive neurons, which could explain differences in excitability. Multiplex in situ hybridization showed similar distributions of tetrodotoxin (TTX)-sensitive NaVs transcripts between TRPM8-positive and -negative Vglut3lineage neurons; however, NaV1.8 transcripts, which encode TTX-resistant channels, were more prevalent in TRPM8-negative neurons. Conversely, pharmacological analyses identified distinct functional contributions of NaV subunits, with NaV1.1 driving firing in menthol-sensitive neurons, whereas other small-diameter Vglut3lineage neurons rely primarily on TTX-resistant NaV channels. Additionally, when NaV1.1 channels were blocked, the remaining NaV currents readily entered into slow inactivation in menthol-sensitive Vglut3lineage neurons. Thus, these data demonstrate that TTX-sensitive NaVs drive action potential firing in menthol-sensitive sensory neurons and contribute to their heightened excitability
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