2026-10-12T08:11:43Z https://data.mendeley.com/oai

oai:data.mendeley.com/2dzmgdmwyz.2 2024-08-14T19:13:50Z

Guo, Shuai Metabologenomic analysis identifies elevated serum sphingosine-1-phosphate as a pathogenic driver of Ménière’s disease Mendeley Data This study enrolled a total of 61 Meniere's disease (MD) patients and 31 healthy controls, all Chinese Han ancestry. Our cohort comprised 28 males (45.90%) with a mean age at diagnosis of 53.5 years (range 26-76 years). To investigate the comprehensive molecular underpinnings of MD, we employed an integrative analysis framework: (1) We performed whole-exome sequencing (WES) on 49 patients and 8 controls to identify recurrently deleterious variants; (2) We conducted metabolomics profiling on 58 patients and 25 controls to uncover metabolic alterations associated with MD; (3) By integrating WES and metabolomics data, we established genotype-metabolite associations; (4) We validated our patient-derived insights using MD mouse model with transcriptome and metabolome data; (5) We further elucidated the dynamics of key metabolic pathways with three public single-cell RNA-seq datasets as well as a bulk MD patient peripheral blood mononuclear cells (PBMCs) dataset. Metabolomics RNA Sequencing Exome Sequencing Huang, Hao Huang, Chao Dataset doi:10.17632/2dzmgdmwyz.2 oai:data.mendeley.com/2dzmgdmwyz.2 Creative Commons Attribution 4.0 International http://creativecommons.org/licenses/by/4.0 https://data.mendeley.com/datasets/2dzmgdmwyz 2024-08-14T19:13:50Z