2026-10-15T21:59:49Z https://data.mendeley.com/oai

oai:data.mendeley.com/3m6ywf2xt5.1 2026-05-08T06:55:44Z

Rocha, Lilian Genomic Evidence for Imiquimod-Mediated Clearance of Mutated Skin in Xeroderma Pigmentosum Mendeley Data In this study, we performed whole-exome sequencing of paired pre- and post-treatment biopsies from XP patients and demonstrated a consistent and substantial reduction in detectable somatic mutational burden following imiquimod therapy. We further characterized mutational signatures, showing persistence of oxidative damage–associated patterns in XP-V patients. Importantly, no tumors developed in treated areas during 24 months of follow-up. To our knowledge, this is the first in vivo human study to evaluate the genomic impact of imiquimod using whole-exome sequencing and mutational signature analysis. These findings provide novel molecular insight into the effects of field-directed therapy and contribute to the understanding of cutaneous field cancerization in high-risk populations. Clinical Health Dataset doi:10.17632/3m6ywf2xt5.1 oai:data.mendeley.com/3m6ywf2xt5.1 Creative Commons Attribution 4.0 International http://creativecommons.org/licenses/by/4.0 https://data.mendeley.com/datasets/3m6ywf2xt5 2026-05-08T06:55:44Z