2026-10-12T01:32:45Z https://data.mendeley.com/oai

oai:data.mendeley.com/cwb7tgbt9y.2 2026-01-21T09:24:49Z

Lund, Amie Traffic-Related Emissions Induce Angiotensin II-Dependent Oxidative Stress in the Hippocampus of ApoE-Null Male Mice Mendeley Data This study tested the hypothesis that exposure to traffic-generated air pollution (MVE) in apolipoprotein null (ApoE-/-) mice leads to increased oxidative stress and amyloid processing, associated with increased renin-angiotensin system (RAS) signaling. Methods: Male ApoE-/- mice (6-8 weeks old) on a high-fat diet were treated with either an ACE inhibitor (captopril, 4 mg/kg/day) or water and exposed to filtered air (FA) or MVE (200µg PM/m³) for 30 days. Real-time qPCR was used to analyze cerebral endpoints, double immunofluorescence to analyze protein expression in the CA1 region of the hippocampus, and an ELISA to quantify plasma angiotensin II levels. Air Pollution Alzheimer's Disease Angiotensin Apolipoprotein E Vehicular Exhaust Armstrong, Tyler Suwannasual, Usa Stanley, Lanie Johnson, Bailee Santiago, Isabella Cook, Mickaela (Mia) Giasolli, Sophia Dataset doi:10.17632/cwb7tgbt9y.2 oai:data.mendeley.com/cwb7tgbt9y.2 Creative Commons Attribution 4.0 International http://creativecommons.org/licenses/by/4.0 https://data.mendeley.com/datasets/cwb7tgbt9y 2026-01-21T09:24:49Z