2026-10-14T14:39:37Z https://data.mendeley.com/oai

oai:data.mendeley.com/j6ds96cd5g.1 2022-01-19T21:54:26Z

Suthar, Mehul mRNA-1273 and BNT162b2 mRNA vaccines have reduced neutralizing activity against the SARS-CoV-2 Omicron variant Mendeley Data The SARS-CoV-2 Omicron variant emerged in November 2021 and consists of several mutations within the spike. We used a live virus neutralization assay to examine the neutralizing activity of the Omicron against mRNA vaccine-induced antibody responses. Following 2-4 weeks after primary series of vaccinations, we observed a 30-fold reduction in neutralizing activity against Omicron. Six months after the initial two vaccine doses, sera from naïve vaccinated subjects showed no neutralizing activity against the Omicron. In contrast, COVID-19 recovered individuals six months after receiving the primary series of vaccinations show a 22-fold reduction with majority of the subjects retaining neutralizing antibody responses. In naïve individuals following a booster shot (3rd dose), we observed a 14-fold reduction in neutralizing activity against Omicron and over 90% of subjects show neutralizing activity. These findings show that a 3rd dose is required to provide robust neutralizing antibody responses against the Omicron variant. Immunology Dataset doi:10.17632/j6ds96cd5g.1 oai:data.mendeley.com/j6ds96cd5g.1 Creative Commons Attribution 4.0 International http://creativecommons.org/licenses/by/4.0 https://data.mendeley.com/datasets/j6ds96cd5g 2022-01-19T21:54:26Z 2022-01-30T23:59:59Z