2026-10-13T21:01:54Z https://data.mendeley.com/oai

oai:data.mendeley.com/jt5zfwshm3.1 2025-11-07T10:43:22Z

marchianò, silvia GPBAR1-mediated bile acid sensing in cholangiocytes drives IL-23/Th17-dependent inflammation in PSC Mendeley Data Primary sclerosing cholangitis (PSC) is a progressive cholangiopathy characterized by bile duct inflammation, fibrosis, and increased risk of cholangiocarcinoma. Here we identify the IL-23/IL-17 axis as a central amplifier of PSC and demonstrate that PBT002, an hybrid dual GPBAR1/RORγt ligand, restores immune and metabolic balance in preclinical models. Transcriptome Receptor Primary Sclerosing Cholangitis Microbiota Di Giorgio, Cristina Biagioli, Michele Fiorucci, Stefano Dataset doi:10.17632/jt5zfwshm3.1 oai:data.mendeley.com/jt5zfwshm3.1 Creative Commons Attribution 4.0 International http://creativecommons.org/licenses/by/4.0 https://data.mendeley.com/datasets/jt5zfwshm3 2025-11-07T10:43:22Z