2026-10-15T12:09:52Z https://data.mendeley.com/oai

oai:data.mendeley.com/mtdct7f9kb.1 2026-05-05T13:54:16Z

Frear, Cody The accuracy of frozen section histopathology in the rapid diagnosis of severe cutaneous adverse reactions: A systematic review and meta-analysis Mendeley Data Background: Frozen section analysis enables rapid diagnosis, but its diagnostic accuracy in the setting of severe cutaneous adverse reactions (SCARs) remains poorly defined. Methods: A systematic review and meta-analysis were performed to evaluate the diagnostic performance of frozen sections in the rapid identification of SCARs, with a focus on Stevens-Johnson syndrome / toxic epidermal necrolysis (SJS/TEN), compared to paraffin-embedded sections. Studies were identified from MEDLINE, EMBASE, the Cochrane Library, ISI Web of Science, and SCOPUS. Random-effects models were used for meta-analysis, and study quality was evaluated using the QUADAS-2 and STARD tools. Results: Three diagnostic accuracy studies, comprising 134 patients, were eligible for meta-analysis. For SJS/TEN, pooled sensitivity was 0.91 (95% CI 0.83–0.96) and pooled specificity was 0.90 (95% CI 0.79–0.95), with a diagnostic odds ratio of 91.3 (95% CI 18.1–460.6) The area under the summary receiver operative characteristic (sROC) curve was 0.957. Data for other SCAR subtypes were insufficient for pooled analysis. Turnaround times were inconsistently reported, and risk-of-bias assessments identified high risk in two studies. Conclusion: Frozen sections demonstrate high diagnostic accuracy for the rapid evaluation of SJS/TEN, but the evidence is confined to a limited number of small, heterogeneous studies. Dermatology Steven-Johnson Syndrome Histopathology Toxic Epidermal Necrolysis Dataset doi:10.17632/mtdct7f9kb.1 oai:data.mendeley.com/mtdct7f9kb.1 Creative Commons Attribution 4.0 International http://creativecommons.org/licenses/by/4.0 https://data.mendeley.com/datasets/mtdct7f9kb 2026-05-05T13:54:16Z