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oai:data.mendeley.com/n66n5pj4f6.2 2020-09-12T00:52:27Z

Ramirez, Sydney Antigen-specific adaptive immunity to SARS-CoV-2 in acute COVID-19 and associations with age and disease severity. Moderbacher et al. Mendeley Data We conducted an analysis of SARS-CoV-2 specific adaptive immune responses during acute COVID-19 in comparison with convalescent COVID-19 and unexposed, healthy controls and identified that coordination between SARS-CoV-2-specific CD4 T cells and CD8 T cells limits disease severity in COVID-19. Aged individuals more often exhibited uncoordinated adaptive responses, potentially tied to scarcity of naive T cells, highlighting immunologic risk factors linked to COVID-19 disease severity. The data available here include all of the supplementary tables and figures, as well as a simplified parameters sheet with experimental and donor information for the healthy unexposed, acute COVID-19, and convalescent COVID-19 donor samples included in this study. Additional information about the supplementary materials, fields, field names, calculations, and patient cohorts are all provided in the published paper. Immunology Antibody T Cell Adaptive Immunity Severe Acute Respiratory Syndrome Coronavirus 2 COVID-19 Rydyznski Moderbacher, Carolyn Dan, Jennifer Grifoni, Alba Hastie, Kathryn Weiskopf, Daniela Belanger, Simon Abbott, Robert Kim, Christina Choi, Jinyong Kato, Yu Crotty, Eleanor Kim, Cheryl Rawlings, Stephen Mateus, Jose Tse, Long Ping Victor Frazier, April Baric, Ralph Peters, Bjoern Greenbaum, Jason Ollmann Saphire, Erica Smith, Davey Sette, Alessandro Crotty, Shane Dataset doi:10.17632/n66n5pj4f6.2 oai:data.mendeley.com/n66n5pj4f6.2 Creative Commons Attribution 4.0 International http://creativecommons.org/licenses/by/4.0 https://data.mendeley.com/datasets/n66n5pj4f6 2020-09-12T00:52:27Z