2026-10-14T05:50:25Z https://data.mendeley.com/oai

oai:data.mendeley.com/ngktxkzhw7.1 2024-12-11T17:09:28Z

pandey, sarita Pax6 co-expresses and gets compartmentalized in the heart of diabetic mice Mendeley Data The Paired box (Pax6), a highly conserved transcription factor, and Tgf-β1 are involved in various cellular functions such as differentiation, activation of extracellular matrix proteins, epithelial-mesenchymal transition, production of cytokines, MAPK, NF-kB, PI3K, Tgf-βs, TLRs, and insulin signaling pathways. In the present study, it was observed that the epicardial, myocardial, and endocardial structures were distorted, and co-expression and compartmentalization of Pax6 and Tgf-β1 occurred in different layers of diabetic mice compared to the control. In the heart, Pax6 expression promotes cardiac fibroblast differentiation via maintaining Tgf-β1 levels. The Tgf-β1 is a pleiotropic cytokine involved in many biological functions. The ligand of Tgf-β1 and their signaling molecules are necessary for the heart's development and normal cardiovascular function. The high level of glucose stimulates Tgf-β1 dependent pathways and activates Tgf-β1 further leading to cardiac fibrosis which includes cardiac hypertrophy through SMAD-dependent and independent (canonical and non-canonical) pathways. Since expression of Tgf-β1 and Pax6 has been proven to be critical for the functional anatomy of the heart, Tgf-β1 and Pax6 might function like tissue-dependent regulation through various signaling pathways or networks. Results suggest that Tgf-β1 and Pax6 have a crucial role in the differentiation and development of cardiac fibroblasts and also regulate the differentiation of fibroblasts into myofibroblasts via SMAD-dependent and independent (canonical and non-canonical) pathways. However, the maintenance and differentiation of cardiac fibroblasts may lead to novel therapy in some patients with cardiac dysfunction. Western Blot Immunochemistry Animal Histology Quantitative Reverse Transcription Polymerase Chain Reaction Dataset doi:10.17632/ngktxkzhw7.1 oai:data.mendeley.com/ngktxkzhw7.1 Creative Commons Attribution 4.0 International http://creativecommons.org/licenses/by/4.0 https://data.mendeley.com/datasets/ngktxkzhw7 2024-12-11T17:09:28Z