2026-10-15T11:54:46Z https://data.mendeley.com/oai

oai:data.mendeley.com/p36hd8ywz5.1 2021-05-06T06:16:55Z

Nemudryi, Artem SARS-CoV-2 genomic surveillance identifies naturally occurring truncation of ORF7a that limits immune suppression. Nemudryi et al. Mendeley Data Over 950,000 whole-genome sequences of SARS-CoV-2 have been determined for viruses isolated from around the world. These sequences have been critical for understanding the spread and evolution of SARS-CoV-2. Using global phylogenomics, we show that mutations frequently occur in the C-terminal end of ORF7a. We have isolated one of these mutant viruses from a patient sample and used viral challenge experiments to link this isolate (ORF7aΔ115) to a growth defect. ORF7a has been implicated in immune modulation. We show that the C-terminal truncation negates the anti-immune activities of the protein, which results in elevated type I interferon response to the viral infection. Collectively, this work indicates that ORF7a mutations occur frequently and that these changes affect viral mechanisms responsible for suppressing the immune response. Natural Sciences Dataset doi:10.17632/p36hd8ywz5.1 oai:data.mendeley.com/p36hd8ywz5.1 Creative Commons Attribution 4.0 International http://creativecommons.org/licenses/by/4.0 https://data.mendeley.com/datasets/p36hd8ywz5 2021-05-06T06:16:55Z