2026-10-15T12:08:54Z https://data.mendeley.com/oai

oai:data.mendeley.com/rthpp2ktb7.3 2026-06-26T17:43:21Z

Caggiano, Cameron Hypothalamic amyloid levels are associated with early sex-dependent alterations in energy homeostasis in TgF344-AD rats Mendeley Data Dataset accompanying the 2026 article: Hypothalamic amyloid levels are associated with early sex-dependent alterations in energy homeostasis in TgF344-AD rats. We hypothesized a bi-directional relationship between peripheral metabolic impairments and Alzheimer's disease neuropathology. This dataset includes pre and post-mortem measurements from male and female Tgf344-AD rats. We detected soluble amyloid beta 40 and 42 in the hypothalamus of TgF344-AD rats alongside sex-dependent impairments in peripheral metabolic indices. Amyloid beta 42 positively correlates with separate impaired measures in male versus female TgF344-AD rats. These findings suggest that Alzheimer's disease pathology in the hypothalamus may induce or contribute to peripheral metabolic impairments in a sex-dependent fashion which can then exacerbate AD pathology. The readme text file contains salient information about experimental design and measurements taken. Hypothalamus Western Blot Alzheimer's Disease ELISA Sandwich Body Temperature Finding Body Fat Mass Blood Glucose High-Fat Diet Levine, Caleb Anderson, Thea Lail, Hannah Dataset doi:10.17632/rthpp2ktb7.3 oai:data.mendeley.com/rthpp2ktb7.3 Creative Commons Attribution 4.0 International http://creativecommons.org/licenses/by/4.0 https://data.mendeley.com/datasets/rthpp2ktb7 2026-06-26T17:43:21Z