2026-10-15T08:48:38Z https://data.mendeley.com/oai

oai:data.mendeley.com/s6c52nhshb.1 2025-09-25T15:18:09Z

Torreno, Fernan Meta-Analysis Dataset: Effectiveness of HIV Pre-Exposure Prophylaxis (PrEP) Across 100 Studies (2000–2025) Mendeley Data This dataset presents a comprehensive meta-analysis of HIV pre-exposure prophylaxis (PrEP) effectiveness across 100 studies conducted between 2000 and 2025. The included studies represent a mix of randomized controlled trials (62 studies) and observational studies (38 studies) conducted globally, encompassing diverse populations at heightened risk of HIV infection: • Men who have sex with men (MSM) (42 studies) • Serodiscordant couples (18 studies) • People who inject drugs (PWID) (12 studies) • High-risk heterosexuals (28 studies) PrEP interventions covered in the analysis include both oral formulations (84 studies) and long-acting injectable cabotegravir (CAB) (16 studies). The study adhered to PRISMA guidelines for systematic review and meta-analysis. A total of 2,134 records were initially identified, with 100 studies meeting inclusion criteria after full-text screening. Outcomes assessed include: • HIV incidence reduction (relative risk, confidence intervals) • PrEP adherence metrics (pill count, electronic monitoring, plasma levels, self-report) • Safety and tolerability outcomes (GI events, renal function, bone density, injection-site reactions) • Risk of bias assessment using the Cochrane tool (for RCTs) and Newcastle-Ottawa Scale (for observational studies). Findings highlight consistently high effectiveness among MSM (≈90% risk reduction with high adherence), substantial benefit in serodiscordant couples (≈75%), moderate protection among PWID (≈49%), and variable efficacy in heterosexual populations (46–77%). Adherence emerged as a critical determinant of effectiveness. This dataset provides a modular synthesis matrix and detailed evidence tables that can be used by researchers, clinicians, and policymakers to optimize PrEP implementation strategies, improve adherence support, and inform public health guidelines. Socialization and Social Development Flores , Frincess Dataset doi:10.17632/s6c52nhshb.1 oai:data.mendeley.com/s6c52nhshb.1 Creative Commons Attribution 4.0 International http://creativecommons.org/licenses/by/4.0 https://data.mendeley.com/datasets/s6c52nhshb 2025-09-25T15:18:09Z