2026-10-16T00:50:53Z https://data.mendeley.com/oai

oai:data.mendeley.com/sh48gkj9sc.1 2025-12-12T15:23:15Z

Morita, Rimpei IL-18 produced by pregnant uterus promotes essential inflammatory responses and fetoplacental growth. Ino et al. Mendeley Data [Summery] Placental insufficiency affects fetomaternal health throughout life. Although the interaction between the maternal uterine immune milieu and fetal-derived cells plays a crucial role in placental formation, several aspects remain unclear. Therefore, we conducted this study to investigate the effects of interleukin (IL)-18, a distinctive cytokine with both proinflammatory and anti-inflammatory properties, on the uterine immune milieu and placental development. Our results identified pregnant uterine smooth muscle cells as an important source of IL-18, which supports homeostatic type 1 immune responses. IL-18 facilitates appropriate placental development through uterine vascular remodeling and placental angiogenesis. Smooth muscle cell–specific Il18-knockout dam mice exhibited excessive cytotoxicity of uterine NK cells, impaired fetoplacental growth, and elevated maternal blood pressure, reflecting preeclampsia-like phenotypes. Their offspring demonstrated a tendency toward excessive weight gain and delayed neurodevelopment. Overall, this study emphasizes the essential role of IL-18 in placental formation and its wider implications for fetomaternal health. [Deposited dataset] We have deposited the raw, uncropped Western blot data prior to cropping. Each .zip archive is labeled to match the corresponding figure name in the manuscript. -Ino_et_al_Figure1.zip --1A_NLRP3_WB.tiff --1A_GAPDH_WB.tiff --1A_Caspase1_WB.tiff --1A_IL-18_WB.tiff --1A_Summery_WB.tif -Ino_et_al_FigureS1.zip --S1A_Caspase11_WB.tiff --S1A_GasderminD_WB.tiff --S1A_Caspase8_WB.tiff --S1A_GAPDH_WB.tiff --S1A_Summery_WB.tif Western Blot Ino, Hajime Negishi, Yasuyuki Horii, Yumi Koike, Eri Flavell, Richard Suzuki, Shunji Dataset doi:10.17632/sh48gkj9sc.1 oai:data.mendeley.com/sh48gkj9sc.1 Creative Commons Attribution 4.0 International http://creativecommons.org/licenses/by/4.0 https://data.mendeley.com/datasets/sh48gkj9sc 2025-12-12T15:23:15Z