2026-10-12T14:00:50Z https://data.mendeley.com/oai

oai:data.mendeley.com/t7ppsjcgw4.1 2026-04-14T12:47:10Z

Forbes, Neil Salmonella vector creates de novo parvovirus that reduces solid tumors and forms antitumor immune memory Mendeley Data We have created a Salmonella vector that delivers oncolytic viruses (OVs) into solid tumors. Despite their potential, OVs are cleared after systemic injection and are not effective against internal tumors. When injected intravenously, virus-delivering Salmonella (VDS) is safe and colonizes tumors 50 million times more than clearance organs. After colonization, VDS invades cancer cells, releases a virus-encoding plasmid, and initiates virion formation. Bacterial delivery of the H-1 parvovirus reduces both hepatocellular and pancreatic tumors, increases survival, and triggers the formation of tumor-specific splenocytes that prevent re-implantation. Treating with VDS increases dendritic cells, infiltration of CD8 T cells, and polarized macrophages. Intravenous injection of VDS produces the same responses as an intratumoral injection, and outperforms direct injection of H-1PV, which minimally affects immune responses and tumor volume. Combining bacteria and OVs creates a therapy that activates the immune system, generates antitumor immunity, and provides a promising platform for treating solid tumors. Oncology Drug Delivery Oncolytic Virus Khanduja, Shradha Raman, Vishnu Hall, Christopher Howell, Lars Van Dessel, Nele Dataset doi:10.17632/t7ppsjcgw4.1 oai:data.mendeley.com/t7ppsjcgw4.1 Attribution-NonCommercial 3.0 Unported https://creativecommons.org/licenses/by-nc/3.0 https://data.mendeley.com/datasets/t7ppsjcgw4 2026-04-14T12:47:10Z