2026-10-15T17:56:18Z https://data.mendeley.com/oai

oai:data.mendeley.com/tnbksjfv36.1 2023-07-20T20:58:40Z

Ciurli, Alessio Spatially and temporally resolved metabolome of the oral human cavity, negative ionization mode, batch 1 Mendeley Data BACKGROUD: Saliva samples (#159) from 20 healthy volunteers, including ten males and ten females was analyzed using a semi-targeted LC-MS/MS platform. SAMPLE NAMES: Structure: [polarity]_[batch]_[sample type]_[subject id]_[time of collection]_[oral location]_[injection number]. explanation: Polarity (neg = negative, pos = positive), batch (1, 2), sample type (blank, QC, sample), time (M = morning, A = afternoon, E = evening), oral location (AT = above the tongue, BT = below the tongue, CK = cheek) Note: When subject id, time of collection, and oral location for blank and QC sample type are equal to 0. RESULTS: Many the metabolites that exhibit heterogeneous distribution, several important metabolites are linked to oral health, such as N-acetylated metabolites, L-ornithine, saccharides, and guanosine monophosphate. Next to the spatial distribution of metabolites, we identified known and novel time dependencies. Among the novel diurnal metabolites, N-acetyl methionine, N,N,N-trimethyl lysine, and N-acetyl tryptophan revealed diurnal patterns in all oral locations. Where the former two behave similarly to cortisol, and the latter has its nadir in the M. Moreover, a pool of amino acids and mono-phosphorylated nucleotides manifested a significant diurnal rhythm exclusively in BT. Liquid Chromatography Tandem Mass Spectrometry Derks, Rico Giera, Martin Dataset doi:10.17632/tnbksjfv36.1 oai:data.mendeley.com/tnbksjfv36.1 Creative Commons Attribution 4.0 International http://creativecommons.org/licenses/by/4.0 https://data.mendeley.com/datasets/tnbksjfv36 2023-07-20T20:58:40Z