2026-10-15T17:56:07Z https://data.mendeley.com/oai

oai:data.mendeley.com/x64tw97rc6.1 2025-06-12T07:32:13Z

Guan, tangfei The Extract of Periplaneta Americana (L.) Promotes Hair Regrowth in Mice with Alopecia by Regulating the FOXO/PI3K/AKT Signaling Pathway and Skin Microbiota Mendeley Data Abstract: (1) Background: Alopecia, a prevalent dermatological disorder affecting over half of the global population, is strongly associated with psychological distress. Extracts from Periplaneta americana (L. PA), a medicinal insect resource, exhibit pharmacological activities (e.g., antioxidant, anti-inflammatory, microcirculation improvement) that align with core therapeutic targets for alopecia. This study aimed to systematically investigate the efficacy and mechanisms of PA extracts in promoting hair regeneration. (2) Methods: A strategy combining network pharmacology prediction and in vivo experiments was adopted. The efficacy of Periplaneta americana extract was validated by evaluating hair regrowth status and skin pathological staining in C57BL/6J mice. Transcriptomics, metabolomics, RT-qPCR, and 16s rRNA techniques were integrated to dissect the underlying mechanisms of its hair-growth-promoting effects. (3) Results: PA-011 significantly promoted hair regeneration in depilated mice via multiple mechanisms: Enhanced skin superoxide dismutase activity and upregulated vascular endothelial growth factor expression; Modulated FOXO/PI3K/AKT signaling pathway and restored skin microbiota homeostasis; Accelerated transition of hair follicles from telogen to anagen phase. (4) Conclusion: PA-011 exerts hair-promoting effects through synergistic modulation of FOXO/PI3K/AKT signaling and skin microbiome. As a novel therapeutic candidate, it warrants further systematic investigation for clinical translation. Pharmacology Dataset doi:10.17632/x64tw97rc6.1 oai:data.mendeley.com/x64tw97rc6.1 Creative Commons Attribution 4.0 International http://creativecommons.org/licenses/by/4.0 https://data.mendeley.com/datasets/x64tw97rc6 2025-06-12T07:32:13Z