Contributors:F.M. Siam, M. Grinfeld, A. Bahar, H.A. Rahman, H. Ahmad, F. Johar
The main goal of our study is to develop a realistic mechanistic model of the effect of ionizing radiation on DNA in mammalian cells. We consider a population of cells structured by the number of DNA double strand breaks due to radiation. Using the system of linear differential equation, the model describes the evolution of the irradiated population of cells in time. The work is in three parts. First, we consider the effect of a single dose of radiation, while in the second part we work on the model parameter estimation using Nelder–Mead simplex algorithm which allows us to relate the clinically useful parameters of the LQ relation to aspects of cellular activity that can be manipulated experimentally. In the third part, we deal with cell killing effects of fractioned doses of radiation. Using MATLAB, we observed the cell survival fractions can be well approximated by the Linear–Quadratic relation and also show fewer cell will die if the dose is fractionated in two or more fractions.
A promising mesoporous SiAl material, Al-MCM-41 was successfully prepared by alkali calcination leaching of natural palygorskite, and sequent hydrothermal synthesis coupled with calcination. The morphology, structure, surface area and pore-size distribution of the material were characterized by scanning electron microscopy, small-angle X-ray diffraction and N2 adsorption–desorption isotherms. The Al-MCM-41 possessed better crystallinity and larger specific surface area with CTAB/SiO2 mass ratio of 0.1:1, pH of 5, crystallization temperature of 110 °C, crystallization time of 12 h and calcination of 550 °C for 5 h. The Al-MCM-41 was used as an adsorbent for the removal of hazardous aniline dye-basic fuchsin from water. Adsorption kinetics and isotherms analysis indicated that adsorption of basic fuchsin onto Al-MCM-41 followed pseudo-first-order model and Langmuir adsorption isotherm. In addition, intra-particle diffusion was rate determining step of the adsorption process. The results demonstrated that the as-synthesized Al-MCM-41 had potential applications in the treatment of waste water.
Contributors:Beatriz Fernández-Muñiz, José Manuel Montes-Peón, Camilo José Vázquez-Ordás
The sensitivity of occupational accidents to the economic cycle can shed light on the effectiveness of occupational health and safety policies. This work analyses the effect of the economic cycle on occupational accidents in Spain in the period 1994–2014. We first perform a regression analysis to evaluate the relation between GDP growth and incidence rate, comparing Spain and Germany. Statistics on GDP growth (OECD) and standardised incidence rates (from Eurostat) are used. Then, from a sectorial perspective, we perform a variance decomposition analysis to measure the effect of the increase in the incidence rates on the growth in the number of accidents in Spain between 2013 and 2014. We use data disaggregated by sector from national databases on occupational accidents to this end.
Contributors:S. Heide, P. Chariot, P. Green, J. Fabian, J.J. Payne-James
Death and harm is well-recognised in detainees in police custody worldwide. Based on the results of previous global surveys and the CPT (European Committee for the Prevention of Torture) recommendations a questionnaire was developed to summarise the current medical aspects of police custody in European countries. The survey was distributed to named contacts in all European countries. Data from 25 European countries was obtained.
In this paper, an optimal design of linear phase digital finite impulse response (FIR) band stop (BS) filter using the L1-norm based real-coded genetic algorithm (L1-RCGA) is presented. Although RCGA has proved its ability to overcome the drawbacks associated with conventional gradient-based optimization methods of filter design, it is applied here with a novel fitness function based on the L1-norm. This leads to a global optimal solution along with the improvement in filter design with same specifications. The designed filter pursues a better response in terms of flat passband, high stopband attenuation and fast convergence. The simulation results justify that the proposed FIR BS filter using L1-RCGA outperforms the existing optimization techniques, the L1-method and particle swarm optimization (PSO) and the conventional methods such as least-squares (LS) approach, Kaiser window method and the Parks McClellan (PM) algorithm. A detailed analysis is performed to evaluate the performance of the designed filters.