Filter Results
21316 results
  • testing editing of this document
    Data Types:
    • Document
  • In response to changing learner needs, our institution launched a new translational curriculum wherein basic sciences and clinical skills were integrated, longitudinal patient care experiences provided, and earlier opportunities in specialty fields introduced to better inform residency program decisions. Medical students taking the breast imaging elective were enrolled in a breast imaging immersive experience designed to meet the School of Medicine’s core competencies. In focusing the elective on a narrow range of specialized topics and skills, we labeled this experience the Breast Imaging Boot Camp. Outcome data from March 6, 2017, to April 26, 2019, have been analyzed for this report. The modifications made to the elective include: e-mailing a detailed orientation document to students prior to the start of the rotation; assigning students to diagnostic, procedural, and screening roles; the attendance of students at introductory radiology symposia; students’ weekly attendance at institutional multidisciplinary and divisional breast radiologic–pathologic correlation conferences; student self-study assignments using faculty-vetted resources; student participation in breast biopsy simulation and small parts ultrasound laboratories; the development of a student-centric radiology educational website; and student-directed publishing of digital case files. Medical student feedback and course analytics indicated superior course evaluation scores reinforced by narrative feedback. In website domain utilization data, the breast file domain is the most viewed subspecialty domain. The Breast Imaging Boot Camp is a successful curriculum. Its novelty lies in both its integrated approach to medical student core competencies and its clinician educators’ use of today’s student-favored teaching tools.
    Data Types:
    • Document
  • In Liberated Threads: Black Women, Style, and the Global Politics of Soul (2017), author Tanisha Ford examines how black women in the latter half of the twentieth century used fashion as a means of protest. In conversations about politics and activism, topics such as government policies and state structures often arise, but rarely that of fashion. Although fashion and politics are often thought to exist separately from one another, Ford proves that the two are intertwined and highlights how black women used clothing in the soul era as a political statement to further advance their views on equality.
    Data Types:
    • Document
  • Beginning content for journal issue including: General information about the journal; Chair's Note from Eunice N. Sahle, Chair of the Department of African, African American, and Diaspora Studies; list of members of the Editorial Team and Advisory Board; Contributor biographies; Table of Contents
    Data Types:
    • Document
  • Traditionally, the emergence of coronaviruses (CoVs) has been attributed to a gain in receptor binding in a new host. Our previous work with severe acute respiratory syndrome (SARS)-like viruses argued that bats already harbor CoVs with the ability to infect humans without adaptation. These results suggested that additional barriers limit the emergence of zoonotic CoV. In this work, we describe overcoming host restriction of two Middle East respiratory syndrome (MERS)-like bat CoVs using exogenous protease treatment. We found that the spike protein of PDF2180-CoV, a MERS-like virus found in a Ugandan bat, could mediate infection of Vero and human cells in the presence of exogenous trypsin. We subsequently show that the bat virus spike can mediate the infection of human gut cells but is unable to infect human lung cells. Using receptor-blocking antibodies, we show that infection with the PDF2180 spike does not require MERS-CoV receptor DPP4 and antibodies developed against the MERS spike receptor-binding domain and S2 portion are ineffective in neutralizing the PDF2180 chimera. Finally, we found that the addition of exogenous trypsin also rescues HKU5-CoV, a second bat group 2c CoV. Together, these results indicate that proteolytic cleavage of the spike, not receptor binding, is the primary infection barrier for these two group 2c CoVs. Coupled with receptor binding, proteolytic activation offers a new parameter to evaluate the emergence potential of bat CoVs and offers a means to recover previously unrecoverable zoonotic CoV strains. IMPORTANCE Overall, our studies demonstrate that proteolytic cleavage is the primary barrier to infection for a subset of zoonotic coronaviruses. Moving forward, the results argue that both receptor binding and proteolytic cleavage of the spike are critical factors that must be considered for evaluating the emergence potential and risk posed by zoonotic coronaviruses. In addition, the findings also offer a novel means to recover previously uncultivable zoonotic coronavirus strains and argue that other tissues, including the digestive tract, could be a site for future coronavirus emergence events in humans.
    Data Types:
    • Document
  • This paper describes a research design and infrastructure implementation to test how users rely upon information cards within web search results pages and what level of credibility they place in their responses.
    Data Types:
    • Document
  • This document summarizes the rationale, equipment, measurement, protocol and data cleaning procedures for each of the cardiovascular measures collected at the Wave V home exam. It also documents how constructed variables were derived from the cardiovascular measures collected in the field. Whenever possible, data collection and methods in Wave V mirrored those of Wave IV to ensure comparability of data between waves. This document is one in a set of Wave V user guides. User guides are also available to describe protocols for the following biological measures in Wave V: ▪ Anthropometrics ▪ Medication Use ▪ Baroreflex Sensitivity & Hemodynamic Recovery ▪ Glucose Homeostasis ▪ Inflammation and Immune Function ▪ Lipids ▪ Renal Function ▪ Liver Enzymes
    Data Types:
    • Document
  • Human rights articles in the 2010 Constitution of Kenya institutionalize freedom from discrimination, security from violence, and compensation for property loss. Demolition projects violate these human rights. This article analyzes the land commission acts that legally permit such demolition projects to occur. Demolition projects destroy not only physical constructions, but also social cohesion within that space. Although there is destruction of space, there is also revival of space. Community Based Organizations (CBOs) are active participants in placemaking and in seeking spatial justice. This case study is focused on Kibera, an informal settlement in Nairobi County. The article begins with a historical analysis of Nairobi city in the context of urbanization and demolition projects and introduces the theme of seeking spatial justice (Soja 2010). Demolition projects pre-dating the 2010 Constitution of Kenya in Kibera are discussed. The article analyzes human rights articles and land commission acts in the 2010 Constitution of Kenya, in addition to how placemaking is involved in the process. Finally, it examines how CBOs are involved in placemaking efforts in Kibera through interviews with community leaders. Space and place stretch beyond mere physical geography and include the complexities of power and social cohesion, even in the face of land policies that contribute to dispossession and displacement for some Kenyan citizens.
    Data Types:
    • Document
  • As with our previous editions, this fourth annual issue of the Global Africana Review (GAR) features the rich and varied scholarship of our undergraduate students. The articles and reviews published here illustrate the intellectually engaged ways in which these emerging scholars grapple with issues of gender, race, citizenship, criminal justice, culture, memory, and social mobilization, building arguments and conclusions around an array of source materials and interpretative interventions. In the best tradition of scholarly publication, these pieces have been reviewed, edited, and revised to enhance their intellectual impact and discursive clarity. This process has allowed these scholars the opportunity to experience writing for a professionally arranged journal, along with the additional rigor and illumination that this work entails.
    Data Types:
    • Document
  • This protocol describes procedures for a systematic review to characterize disparities in provider recommendations for HPV vaccination among US adolescents.
    Data Types:
    • Document