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PHQ-9 and GAD-7 Coded Dataset
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This data is used to analyze the structural equation of the article
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Radiogrammetric parameters of the femur were assessed in an adult sample (N=98) from the Coimbra Identified Skeletal Collection (Portugal). Anteroposterior radiographs of the midshaft area of the left femur of each individual were taken using a mammogram film with an exposure time of mAseg 80-50,exposure of Kv 30-35 and focal distance of 1.0 m. Maximum length of the femur, as defined by Martin and Saller (1957), was determined. Measurements of diaphysis total width (DTW) and medullary width (MW) were taken following a standardized guide. Radiogrammetry was used to establish cortical index (FEMCI) in the femoral mid-shaft. Diaphysis total width (DTW) and femoral cortical index (FEMCI) are significantly higher in males, while medullary width (MW) is not statistically different between sexes. The evaluation of femoral cortical bone reveals sex-specific trajectories of endosteal bone loss and periosteal apposition, stemming from sexual differences in the rate and pattern of bone loss, and in bone size. In females, endocortical bone loss rises with age, particularly in peri- and postmenopausal years, decelerating later in life. Concomitantly, accretion of bone in the subperiosteal surface persists throughout adulthood — partially offsetting bone fragility in women. Strength in the femoral mid-diaphysis appears to be preserved throughout most of the life course in both sexes.
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Provides all origin files used in simulation of impact energy using sigmoidal models.
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Distinguishing between bull Y- and X-bearing sperm populations is advantageous for techniques with sexed bull semen. The aim of this study was to produce a single-chain fragment variable (scFv) antibody against plasma membrane epitopes on bull Y-bearing sperm to distinguish between Y- and X- sperm. Variable heavy (VH) and variable light (VL) region genes generated from a hybridoma cell secreting a specific Y-bearing sperm monoclonal antibody (mAb-1F9) were cloned and expressed. The expected sizes of the DNA bands were ~350 bp for the VH gene and ~318 bp for the VL gene. The VH and VL genes were generated and used to construct an scFv gene (~650 bp) and express the corresponding soluble scFv antibody. Compared with the parent mAb-1F9, the scFv antibodies presented a high affinity for Y-bearing sperm and low cross-reactivity with X-bearing sperm. An immunofluorescence analysis confirmed that the scFv antibodies and mAb-1F9 recognize epitopes on the Y-bearing sperm surface. The fluorescence signal was strong on the plasma membrane of Y-bearing sperm but very weak for X-bearing sperm. This study helps the application and production of engineered scFv antibodies specific to Y-bearing sperm to distinguish between Y- and X-bearing sperm populations for techniques involving sexed bull semen
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This dataset is a bibliographical database associated to the journal article "Twenty Years of Distributed Port-Hamiltonian Systems: A Literature Review" by R. Rashad, F. Califano, A.J. van der Schaft, and S. Stramigioli. In this article we review the research studies carried out in the past twenty years in the field of Distributed Port-Hamiltonian systems. The dataset includes the papers reviewed in this article, classified in their respective groups, which are over 150 studies. In addition, the dataset has an extra of 80 more studies that were not cited in the review paper, but are related to the field. All journal articles and the majority of the conference proceedings have their DOI included in the dataset. The main .bib file is named "Reference_List_Review". We hope this could guide new researchers in the field and accelerate the research and development of this powerful paradigm.
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Data used for plotting figures in the main context. -- First commit: Nov 26th, 2019 for review. -- Second commit: Apt 1st, 2020 for publication
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1H-NMR spectroscopy data from 24-hr urine samples from Diets 1 and 4, Dietary Metabotype Score (DMS), blood glucose measurement and urinary calorific value. Data contains quantified values for identified metabolites (in mmol/ml) of 24-hr urine samples for 19 volunteers for the two reference diets in Excel format. For each sample, the DMS, area-under-the-curve (AUC) glucose and calorific value (in J/g) are also given. This data accompanies Garcia-Perez et al. (2020) "Dietary metabotype modelling predicts individual responses to dietary interventions: A feasibility study" Nature Food (submitted, ref.: NATFOOD-19060125C)
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Mesenchymal stem/stromal cells (MSC) have immunomodulatory properties, studied in a wide range of diseases. Validated Quality Controls must be able to confirm this activity in the context of clinical trials. This study presents the validation of a method, quantifying the ability of MSC to inhibit T cell proliferation according to the ICH Q2 standard. Peripheral blood mononuclear cells (PBMC) from a bank of ten donors, labeled with CellTrace Violet (CTV), were co-cultured with MSC at seven different ratios for seven days. Flow cytometry analysis was used to obtain the percentage of division (PD) of T cells. Two parameters were calculated: the percentage of inhibition (PI) of T cell proliferation, for each ratio X, determined using the following formula PI ratio X = (PD control – PD ratio X) / PD control, and the corresponding area under the curve (AUC). The validation of two different CTV-PBMC banks did not show any statistical difference and demonstrated stability over 509 days of storage. Analysis of repeatability and reproducibility showed a standard deviation (SD) of 6.1% and 4.6%, respectively. Robustness analysis, corresponding to the ability of a method to resist small but deliberate variations in its parameters, for PBMC, and MSC, did not present any difference. The assay was linear on the exploited range and permitted to distinguish MSC presenting different ranges of inhibition activity. This quantification method of MSC immunomodulatory activity displayed low analytical variability, sufficient robustness, and no inter-bank variability of PBMC. Therefore, it could be used for MSC manufacturing batch qualification.
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Amyotrophic lateral sclerosis is a rapidly progressive neurodegeneration disease,with a hall mark of neuronal inclusions, neuron loss and gliosis. The pathogenesis of ALS remains unclear. And the only two drugs riluzole and edaravone exhibit limited efficacy. We then explored the riluzole treatment in TDP-43 transgenic rats trying to uncover the pathological mechanisms of neuron loss in ALS.
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